Leptin and Soluble Leptin Receptor in Serum and Urine of Children with Primary Nephrotic Syndrome Before and After Steroid Therapy

The global task of the recent decade is to search for clinical and laboratory markers accurately showing a patient’s reaction to steroid therapy and other immunosuppressive drugs. It is important the applied methods and tests to be non-invasive and simple to use. The article considers various biomarkers used to verify the type of nephrotic syndrome depending on the sensitivity to steroid therapy. Besides the common markers, which are used in clinical practice or have shown a significant result, the work highlights the molecular- genetic markers of resistance to steroid therapy, which are of special clinical importance today. Also, the article presents authors’ own results in diagnosing the steroid resistance of the primary nephrotic syndrome.

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Soluble Leptin Receptor and Leptin Levels in Pregnant Women Before and After Delivery

Endocrine Research ◽

10.1081/erc-200034301 ◽

2004 ◽

Vol 30 (3) ◽

pp. 379-385 ◽

Cited By ~ 10

Author(s):

Jarmila Krizova ◽

Vladimira Eretova ◽

Denisa Haluzikova ◽

Katerina Anderlova ◽

Jitka Housova ◽

...

Keyword(s):

Pregnant Women ◽

Leptin Receptor ◽

Soluble Leptin Receptor ◽

Before And After

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Circulating Concentrations of Leptin Hormone, Soluble Leptin Receptor and Free Leptin Index in Obese Egyptian Women Before and after Diet Therapy

Journal of Medical Sciences(Faisalabad) ◽

10.3923/jms.2009.219.226 ◽

2009 ◽

Vol 9 (5) ◽

pp. 219-226 ◽

Cited By ~ 1

Author(s):

Salwa M. El-Sheb ◽

Lobna A. Ghattas ◽

Hamed I. Mohamed ◽

Maha I.A. Moaty ◽

Salwa T. Tapozad ◽

...

Keyword(s):

Leptin Receptor ◽

Diet Therapy ◽

Soluble Leptin Receptor ◽

Before And After ◽

Egyptian Women

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Leptin, soluble leptin receptor, and transforming growth factor-?1 levels in minimal change nephrotic syndrome

Pediatric Nephrology ◽

10.1007/s00467-003-1221-2 ◽

2003 ◽

Vol 18 (10) ◽

pp. 1009-1014 ◽

Cited By ~ 7

Author(s):

Necla Buyan ◽

Ozan �zkaya ◽

Aysun Bideci ◽

Oguz S�ylemezoglu ◽

Peyami Cinaz ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Growth Factor ◽

Leptin Receptor ◽

Transforming Growth Factor ◽

Minimal Change Nephrotic Syndrome ◽

Minimal Change ◽

Soluble Leptin Receptor

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On steroid therapy of primary nephrotic syndrome in children

Practical medicine ◽

10.32000/2072-1757-2020-3-26-31 ◽

2020 ◽

Vol 18 (3) ◽

pp. 26-31

Author(s):

S. L. MOROZOV ◽

◽

V. V. DLIN ◽

Keyword(s):

Nephrotic Syndrome ◽

Steroid Therapy ◽

Primary Nephrotic Syndrome

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sPD-1 and sPD-L1 Levels in Serum and Urine of Patients with Primary Nephrotic Syndrome and their Clinical Significance

Clinical Laboratory ◽

10.7754/clin.lab.2020.200913 ◽

2021 ◽

Vol 67 (10/2021) ◽

Author(s):

YingLi Xuan ◽

Feihong Chen ◽

Li Qin ◽

Ruibin He ◽

JiangZi Yuan

Keyword(s):

Nephrotic Syndrome ◽

Clinical Significance ◽

Primary Nephrotic Syndrome ◽

Serum And Urine

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Effect of Steroid Therapy on Thyroid Function Status in Typically and Atypically Presented Nephrotic Syndrome

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v19i1.48799 ◽

2020 ◽

Vol 19 (1) ◽

pp. 28-32

Author(s):

Mitra Datta ◽

Mohammed Maruf Ul Quader ◽

Salina Haque ◽

Sumana Choudhury ◽

Shuvra Das ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Thyroid Function ◽

Steroid Therapy ◽

Subclinical Hypothyroidism ◽

Initial Attack ◽

Significant Difference ◽

Before And After ◽

Grade Ii ◽

Group B

Background: Mild or subclinical hypothyroidism may coexist with NephroticSyndrome (NS). But persistence of this hypothyroidism is related with remission ofproteinuria. Objectives of the study is to compare thyroid function status (FT4 andTSH) in the atypical and typical NS before and 4 weeks after steroid therapy. Materials and methods: This was a hospital based comparative observational studywith prospective follow up of study subjects. It was carried out in the Department ofPediatrics and in the Department of Nephrology, Chattogram Medical CollegeHospital (CMCH) Chattogram, Bangladesh from January to December’ 2017. A total83 diagnosed admitted cases of initial attack idiopathic NS, aged 1-18 years ofeither sex divided into 2 groups were included. Typically presented NS were in groupA and atypically presented NS were in group B. FT4 and TSH were estimated in allpatients on 2 occasions before and 4 weeks after initiation of steroid therapy andcomparison was done between 2 groups. Results: FT4 level was normal before and after steroid therapy in both typically andatypically presented nephrotic syndrome. Before steroid therapy, mean TSH valuewas found significantly raised in both groups (9.28±5.17 vs 7.26±3.67 μIU/ml).Proportion of subclinical hypothyroidism was statistically similar. After treatmentwith steroid, number of subclinical hypothyroid cases reduced in both groups withreduction of TSH value (3.13±1.14 vs 5.38±2.52 μIU/ml). But significant difference inTSH value was observed in between two groups. There was persistence of subclinicalhypothyroidism after treatment with steroid among 16.6 % (14.2% grade II and2.3% grade I) children with atypically presented NS and which is statisticallysignificant (p=0.006). Conclusion: Subclinical hypothyroidism persists in atypically presented nephroticsyndrome even after treatment with steroid. Chatt Maa Shi Hosp Med Coll J; Vol.19 (1); January 2020; Page 28-32

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Serum and Urine ANGPTL8 Expression Levels are Associated with Hyperlipidemia and Proteinuria in Primary Nephrotic Syndrome

10.21203/rs.3.rs-129192/v1 ◽

2020 ◽

Author(s):

Xia Gao ◽

Qingju Liu ◽

Chengdong Kang ◽

Weijing Cui ◽

Zichuan Xu ◽

...

Keyword(s):

Nephrotic Syndrome ◽

High Density Lipoprotein ◽

Density Lipoprotein ◽

Blood Lipid ◽

Healthy Controls ◽

Mesangial Proliferative Glomerulonephritis ◽

Lipid Levels ◽

Primary Nephrotic Syndrome ◽

Serum And Urine ◽

Blood Lipid Levels

Abstract Background: This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlationwith hyperlipidemia and proteinuria.Methods: ANGPTL8 levels were determined using Enzyme‑linked immunosorbentassay in 133 subjects with PNS, and 60 subjects with healthy controls.Results: Subjects with primary nephrotic syndrome had higher levels of serum andurine ANGPTL8 than healthy controls subjects (P < 0.001). In primary nephroticsyndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r =0.209, P < 0.05) and triglycerides (r = 0.412, P < 0.001), while no correlation with24hUTP. Urine ANGPTL8 was positively correlated with high density lipoprotein-cholesterol (r = 0.181, P < 0.05), while urine ANGPTL8 was significantly negativelycorrelated with creatinine (r = -0.323, P<0.001) and 24hUTP (r = -0.268, P = 0.002).Interestingly, urine ANGPTL8 concentrations were different between membranousnephropathy and mesangial proliferative glomerulonephritis pathological types.Conclusions: Serum and urine ANGPTL8 levels in primary nephrotic syndromepatients were correlated with blood lipid levels and proteinuria, respectively, suggestingthat ANGPTL8 may play a role in the development of primary nephrotic syndromehyperlipidemia and proteinuria.

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