scholarly journals INHIBITORY EFFECTS OF ESSENTIAL OILS OF SOME WILD MEDICINAL PLANT SPECIES ON ACTIVITY OF SOME PATHOGENIC FUNGI

2014 ◽  
Vol 19 (3) ◽  
pp. 413-427
Keyword(s):  
Medicinal Plant ◽  
Essential Oils ◽  
Plant Species ◽  
Pathogenic Fungi ◽  
Medicinal Plant Species ◽  
Inhibitory Effects

scholarly journals Anticholinesterase Activity of Eight Medicinal Plant Species: In Vitro and In Silico Studies in the Search for Therapeutic Agents against Alzheimer’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Md Josim Uddin ◽  
Daniela Russo ◽  
Md Mahbubur Rahman ◽  
Shaikh Bokhtear Uddin ◽  
Mohammad A. Halim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medicinal Plant ◽  
Plant Species ◽  
Inhibitory Effect ◽  
Medicinal Plant Species ◽  
Inhibitory Effects ◽  
In Silico Studies ◽  
Blumea Lacera

Many Bangladeshi medicinal plants have been used to treat Alzheimer’s disease and other neurodegenerative diseases. In the present study, the anticholinesterase effects of eight selected Bangladeshi medicinal plant species were investigated. Species were selected based on the traditional uses against CNS-related diseases. Extracts were prepared using a gentle cold extraction method. In vitro cholinesterase inhibitory effects were measured by Ellman’s method in 96-well microplates. Blumea lacera (Compositae) and Cyclea barbata (Menispermaceae) were found to have the highest acetylcholinesterase inhibitory (IC50, 150 ± 11 and 176 ± 14 µg/mL, respectively) and butyrylcholinesterase inhibitory effect (IC50, 297 ± 13 and 124 ± 2 µg/mL, respectively). Cyclea barbata demonstrated competitive inhibition, where Blumea lacera showed an uncompetitive inhibition mode for acetylcholinesterase. Smilax guianensis (Smilacaceae) and Byttneria pilosa (Malvaceae) were also found to show moderate AChE inhibition (IC50, 205 ± 31 and 221 ± 2 µg/mL, respectively), although no significant BChE inhibitory effect was observed for extracts from these plant species. Among others, Thunbergia Grandiflora (Acanthaceae) and Mikania micrantha (Compositae) were found to display noticeable AChE (IC50, 252 ± 22 µg/mL) and BChE (IC50, 314 ± 15 µg/mL) inhibitory effects, respectively. Molecular docking experiment suggested that compounds 5-hydroxy-3,6,7,3′,4′-pentamethoxyflavone (BL4) and kaempferol-3-O-α-L-rhamnopyranosyl-(1⟶6)-β-D-glucopyranoside (BL5) from Blumea lacera bound stably to the binding groove of the AChE and BChE by hydrogen-bond interactions, respectively. Therefore, these compounds could be candidates for cholinesterase inhibitors. The present findings demonstrated that Blumea lacera and Cyclea barbata are interesting objects for further studies aiming at future therapeutics for Alzheimer’s disease.

scholarly journals Antifungal Properties of Selected Medicinal Plant Species Against Fusarium spp. – A Preliminary Study

2018 ◽  
Vol 8 (2) ◽  
pp. 103-108
Author(s):  
Izza Nadira Abu Bakar ◽  
Abdul Raffar Abdul Razak ◽  
Muhammad Nur Hakim Zulkifle ◽  
Nur Aliah Rosli ◽  
Yeo Freddy Kuok San
Keyword(s):  
Medicinal Plant ◽  
Plant Species ◽  
Plant Extracts ◽  
Crude Extract ◽  
Agricultural Practices ◽  
Pathogenic Fungi ◽  
Medicinal Plant Species ◽  
Absolute Methanol ◽  
Fusarium Spp ◽  
Antifungal Properties

Usage of synthetic fungicides has inevitably been one of the agricultural practices in combating crop pathogens and maintaining the quality of production. Although fungicides have been proven to be profoundly effective, excessive and frequent reliance on these synthetic fungicides have caused negative impacts to the environment and human health. Besides that, indiscriminate use of fungicides may lead to the development of resistant strains of pathogenic fungi. The need to find an alternative solution to synthetic fungicides has led to the interest in finding plant-based fungicides. This study aimed to test the antifungal properties of plant extracts from 13 different medicinal plant species towards plant pathogenic fungi. Absolute methanol was used as a solvent to extract the secondary metabolites from the different plant species. The effect of methanolic crude extract at different concentrations (500 g/ml, 250 g/ml and 100 g/ml), from different medicinal plant species, were tested on the growth of two Fusarium spp., FsB and FsP. The assay showed that the methanolic crude extract from six plant species viz. Alpinia galanga, Annona muricata, Archidendron jiringa, Nephelium lappaceum, Polygonum minus and Artocarpus hybrid (Nanchem) had successfully inhibit the radial mycelial growth of either FsB or FsP, or both. The assay suggested that the six plant species have antifungal properties towards the crop pathogenic fungi tested. Keywords: antimicrobial, Fusarium, plant extracts, methanolic extracts, biofungicides

scholarly journals Evaluation of Allelopathic Potentials from Medicinal Plant Species in Phnom Kulen National Park, Cambodia by the Sandwich Method

2020 ◽  
Vol 13 (1) ◽  
pp. 264
Author(s):  
Yourk Sothearith ◽  
Kwame Sarpong Appiah ◽  
Takashi Motobayashi ◽  
Izumi Watanabe ◽  
Chan Somaly ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Plant Species ◽  
National Park ◽  
Medicinal Plant Species ◽  
Inhibitory Effects ◽  
Isolation And Identification ◽  
Radicle Elongation ◽  
Medicinal Value ◽  
Sandwich Method ◽  
North Western

Phnom Kulen National Park, in north-western Cambodia, has huge richness in biodiversity and medicinal value. One hundred and ninety-five (195) medicinal plant species were collected from the national park to examine allelopathic potentials by using the sandwich method, a specific bioassay for the evaluation of leachates from plants. The study found 58 out of 195 medicinal plant species showed significant inhibitory effects on lettuce radicle elongation as evaluated by standard deviation variance based on the normal distribution. Three species including Iris pallida (4% of control), Parabarium micranthum (7.5% of control), and Peliosanthes teta (8.2% of control) showed strong inhibition of lettuce radicle elongation less than 10% of the control. The results presented could present as a benchmark for isolation and identification of allelochemicals among medicinal plants used in Cambodia.

scholarly journals Dormancy break in seeds of "quina" (Strychnos pseudoquina A. St.-Hil.)

2011 ◽  
Vol 13 (4) ◽  
pp. 507-511 ◽  
Author(s):  
J.M. Vasconcelos ◽  
M.A. Rodrigues ◽  
S.C. Vasconcelos Filho ◽  
J.F. Sales ◽  
F.G. Silva ◽  
...  
Keyword(s):  
Sulfuric Acid ◽  
Medicinal Plant ◽  
Gibberellic Acid ◽  
Plant Species ◽  
Germination Percentage ◽  
Boiling Water ◽  
Medicinal Plant Species ◽  
Distilled Water ◽  
Brazilian Cerrado ◽  
Germination Speed

"Quina" (Strychnos pseudoquina A. St. Hil) is a medicinal plant species from the Brazilian Cerrado. As its seeds show dormancy, they were subjected to the treatments pre-cooling at 5ºC during 7 days, pre-heating at 40ºC during 7 days, pre-soaking in sulfuric acid PA during 5 and 15 min, pre-soaking in boiling water during 5 and 15 min, pre-soaking in 100 and 200 ppm gibberellic acid during 48 h, pre-soaking in distilled water during 24 and 48 h, and mechanical scarification to break dormancy. Counts were daily conducted from the 2nd day after the experiment implementation until the germination stabilization at the 65th day. The germination speed index (GSI) and the germination percentage were evaluated. Germination rates above 96% were reached in seeds pre-soaked in water during 48 h and substrate moistened with water or KNO3.

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