SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN

2014 ◽  
Vol 20 (2) ◽  
pp. 1-7
Author(s):  
Shereen El Tarhouny ◽  
Soha Zakaria ◽  
Khaled d Hadhoud ◽  
Manal Hanafi ◽  
Azza Kamel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Globulin Gene

scholarly journals Sex Hormone Binding Globulin Gene Polymorphism and Risk of Type2 Diabetes Mellitus in Egyptian Men

2015 ◽  
Author(s):  
SA El Tarhouny ◽  
SS Zakaria ◽  
AM Abdu-Allah ◽  
KM Hadhoud ◽  
MI Hanafi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Globulin Gene

SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN

2014 ◽  
Vol 20 (1) ◽  
pp. 1-7
Author(s):  
Shereen El Tarhouny ◽  
Soha Zakaria ◽  
Khaled Hadhoud ◽  
Manal Hanafi ◽  
Azza Kamel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Globulin Gene

The association between sex hormone-binding globulin gene polymorphism with bone mineral density

Steroids ◽  
2016 ◽  
Vol 106 ◽  
pp. 9-18 ◽  
Author(s):  
Xiao-Yun Zha ◽  
Yu Hu ◽  
Xiao-Na Pang ◽  
Ji-Heng Zhu ◽  
Gui-Lin Chang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Gene Polymorphism ◽  
Bone Mineral ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Mineral Density ◽  
Globulin Gene

Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome

2007 ◽  
Vol 104 (1-2) ◽  
pp. 68-74 ◽  
Author(s):  
Běla Bendlová ◽  
Jana Zavadilová ◽  
Markéta Vaňková ◽  
Daniela Vejražková ◽  
Petra Lukášová ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Gene Polymorphism ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovary Syndrome ◽  
Globulin Gene

The (TAAAA)npolymorphism of sex hormone-binding globulin gene is not associated with testicular maldescent

Andrologia ◽  
2012 ◽  
Vol 45 (1) ◽  
pp. 40-45 ◽  
Author(s):  
C. Mamoulakis ◽  
N. Sofikitis ◽  
P. Tsounapi ◽  
E. Vlachopoulou ◽  
A. Chatzikyriakidou ◽  
...  
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Globulin Gene

PROFILES OF SEX HORMONES AND SEX HORMONE-BINDING GLOBULIN IN JAPANESE MEN WITH DIABETES MELLITUS

1998 ◽  
Vol 30 (Supplement) ◽  
pp. 197
Author(s):  
S. Kumagai ◽  
S. Takayanagi ◽  
H. Ninomiya ◽  
H. Sasaki
Keyword(s):  
Diabetes Mellitus ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Japanese Men

scholarly journals Association of sex hormone-binding globulin and free testosterone with mortality in men with type 2 diabetes mellitus

2016 ◽  
Vol 174 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Aye N Tint ◽  
Rudolf Hoermann ◽  
Henry Wong ◽  
Elif I Ekinci ◽  
Richard J MacIsaac ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Inverse Association ◽  
Hormone Binding ◽  
All Cause Mortality

ObjectiveLow circulating testosterone levels have been associated with increased mortality in men. We hypothesized that the prognostic role of testosterone in men with type 2 diabetes mellitus (T2DM) is influenced by its carrier protein sex hormone-binding globulin (SHBG).DesignWe conducted a prospective cohort study at a tertiary referral centre.MethodsIn total, 531 men with T2DM presenting to a diabetes clinic in 2004–2005 were followed prospectively until death, or July 31, 2014, and a survival analysis was performed. The main outcome measure was all cause mortality.ResultsOver a mean (s.d.) follow up of 7.6 years (2.6) 175 men (33%) died. In Cox proportional hazard models both higher SHBG (Hazard Ratio (HR) 1.012 (95% CI 1.002–1.022), P=0.02) and lower calculated free testosterone (cFT) (HR 0.995 (95% CI 0.993–0.998), P=0.001) were risk factors for all cause mortality independently of age, BMI, presence of macro- and microvascular disease, duration of T2DM, hemoglobin, renal function, insulin use, C-reactive protein and homeostatic model of insulin resistance. By contrast, the inverse association of total testosterone (TT) with mortality weakened after these adjustments (P=0.11). SHBG remained associated with mortality (P<0.001) both if substituted for or added to TT in the multivariable model. In the fully adjusted model, an increase of SHBG by 17.3 nmol/l (1 s.d.) increased mortality by 22% and a decrease in cFT by 81 pmol/l (1 s.d.) increased mortality by 45%.ConclusionsThe association of SHBG with mortality in men with T2DM is novel. Whether SHBG acts via regulation of testosterone, has intrinsic biological roles, or is a marker of poor health requires further study.

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