scholarly journals Role of Colour Doppler in Evaluation of Hemodynamic Changes in Chronic Hepatitis C Infection

2016 ◽  
Vol 22 (2) ◽  
Author(s):  
Mahjabeen Masood ◽  
Iqbal Hussain Dogar ◽  
Mahesh Gautam ◽  
Ghulam Rasul
Keyword(s):  
Hepatitis C ◽  
Portal Vein ◽  
Tissue Level ◽  
Study Patient ◽  
Hepatitis C Infection ◽  
Doppler Study ◽  
Vein Diameter ◽  
Liver Hemodynamics ◽  
Splenic Size

Objective:  The objective of this study is to determine the role of colour flow Doppler ultrasound examination for detection of change in liver hemodynamic in hepatitis C positive chronic liver disease.Materials and Methods:  This study was conducted in Department of Radiology, Mayo Hospital Lahore from 2012 to 2013. Hundred diagnosed case of Hepatitis C by serology were included in this study. Patient were examined for liver and spleen size, texture and presence and absence of ascites before Doppler study. All the data were coded and analyzed using SPSS version 20.Results:  Mean age of the patient was found to be 45.90 ± 12.71 years. The echotexture of liver was normal in 29 patients (29.0%), coarse with smooth margins in 48 patients (48.0%) and coarse with irregularSMO, Department of Radiology, Children Hospital, Lahoremargins in 23 patients (23.0%). Splenic size was enlarged (≥ 13 cm) in 63.0%. Portal vein diameter was enlarged in (≥ 13 mm) in 53.0%. Severity of ascites shows mild ascites in 24.0%, moderate in 24.0% and severe in 19.0% patients. Portal vein velocity shows abnormality (≥ 24cm/sec) in 63.0%. Hepatic vein waveform in 71.0% of patients was triphasic and non-triphasic in 29.0%.Conclusion:  In conclusion alterations of liver hemodynamics resulting from inflammation at the tissue level are detectable in Doppler sonography.

Portal vein thrombosis in hepatitis C virus-related cirrhotic patients: Prevalence and clinical characteristics in an Egyptian cohort

2021 ◽  
pp. 004947552199850
Author(s):  
Omkolsoum Alhaddad ◽  
Maha Elsabaawy ◽  
Omar Elshaaraawy ◽  
Mohamed Elhalawany ◽  
Mohamed Mohamed Houseni ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Clinical Characteristics ◽  
Abdominal Ultrasound ◽  
Focal Lesion ◽  
Vein Thrombosis ◽  
Doppler Study ◽  
Cirrhotic Patients

Portal vein thrombosis is a catastrophe not uncommonly complicating hepatitis C virus-related liver cirrhosis. To estimate its prevalence and clinical characteristics, we investigated 1000 cirrhotic patients by abdominal ultrasound or Doppler study at least. Portal vein thrombosis was found in 21.6%, of whom 157 (72.7%) had malignancy. Complete portal vein thrombosis was found in 70.4%. Half of all these patients had at least one episode of portal hypertensive bleeding, a third had abdominal pain and a quarter presented with jaundice. Portal bilopathy was diagnosed in two cases (0.9%). There was significant association between severity of liver disease, ascites, male gender and site of segmental focal lesion and portal vein thrombosis.

scholarly journals Increased levels of circulating IL-10 in persons recovered from hepatitis C virus (HCV) infection compared with persons with active HCV infection

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Dorcas Ohui Owusu ◽  
Richard Phillips ◽  
Michael Owusu ◽  
Fred Stephen Sarfo ◽  
Margaret Frempong
Keyword(s):  
Hepatitis C ◽  
Spontaneous Recovery ◽  
Predictive Marker ◽  
Serum Levels ◽  
Hcv Infection ◽  
Tnf Alpha ◽  
Hepatitis C Infection ◽  
Ifn Gamma ◽  
The Relationship

Abstract Objective Approximately 70% of all hepatitis C (HCV) infections develop chronic disease. Active or exacerbated chronic hepatitis C infection subsequently progress to liver disease. The role of T-cells secretions in achieving viral clearance is still not well understood. Thus, the current study was set to determine the relationship between the T cell cytokine profiles, biochemical parameters and persistent HCV infection or spontaneous recovery. Results Twenty-five percent (41/163) of the anti-HCV positive participants had recovered from HCV and had significantly higher concentration of IL-10 compared to those with active HCV infection (P < 0.012). Other circulating cytokines measured; IL-2, IFN gamma, TNF alpha, IL-5 and IL-17 were similar in both groups. Participants with active HCV infection had significantly higher aspartate transaminase (AST) (35 units) and alanine transaminase (46 units) compared to those in the recovered state (P < 0.001). Thus, serum levels of IL10 could be explored in larger prospective cohort study as a predictive marker of recovering from an active HCV infection.

Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis c infection

2002 ◽  
Vol 34 (5) ◽  
pp. 1771-1773 ◽  
Author(s):  
S Baid ◽  
N Tolkoff-Rubin ◽  
M.L Farrell ◽  
F.L Delmonico ◽  
W.W Williams ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hepatitis C ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Hepatitis C Infection

scholarly journals Role of regulatory T-cells during hepatitis C infection: From the acute phase to post-transplantation recurrence

2015 ◽  
Vol 47 (11) ◽  
pp. 913-917 ◽  
Author(s):  
Clément Barjon ◽  
Géraldine Dahlqvist ◽  
Yvon Calmus ◽  
Filomena Conti
Keyword(s):  
T Cells ◽  
Hepatitis C ◽  
Regulatory T Cells ◽  
Acute Phase ◽  
Hepatitis C Infection ◽  
Post Transplantation

[447] ROLE OF CCR5 AND CXCR3 CHEMOKINE RECEPTORS EXPRESSION ON CD8+ CELLS DURING CHRONIC HEPATITIS C INFECTION

2007 ◽  
Vol 46 ◽  
pp. S170 ◽  
Author(s):  
M. Calvino ◽  
S. Benito ◽  
T. Parra ◽  
J. Perez de Hornedo ◽  
A. Arias ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Chemokine Receptors ◽  
Hepatitis C Infection ◽  
Cd8 Cells

scholarly journals Probing the viral replication of HCV and XMRV : biochemical characterization, inhibition kinetics and role of host proteins in viral replication

2015 ◽  
Author(s):  
◽  
Tanyaradzwa P. Ndongwe
Keyword(s):  
Hepatitis C ◽  
Viral Replication ◽  
Reverse Transcriptase ◽  
Rna Binding ◽  
Biochemical Characterization ◽  
Hcv Rna ◽  
Hepatitis C Infection ◽  
Human Hepatoma Cells ◽  
Murine Leukemia

The studies described in this thesis focus on RNA viruses XMRV and HCV. In Chapter II we focused on Xenotropic Murine leukemia-Related Virus (XMRV). We characterized the biochemical activity and kinetics of the XMRV reverse transcriptase and discovered key mechanistic differences between XMRV, Moloney murine leukemia virus (MoMLV), and human immunodeficiency virus (HIV-1) reverse transcriptase (RT) enzymes. In Chapter III and IV we focused on Hepatitis C Virus (HCV), the causative agent of hepatitis C infection. We studied the role of an antiviral host factor Mov10 in the viral replication of HCV. We demonstrate that Mov10 overexpression in human hepatoma cells restricts HCV RNA production in a fully infectious virus cell culture system, leading to decreased virus production over time. Additionally, overexpression of Mov10 in producer cells decreases the infectivity of the produced virus. Confocal microscopy shows HCV infection results in redistribution of endogenous Mov10 to circular structures surrounding lipid droplets, proximal to viral proteins core and NS5A. Finally, we demonstrate that the RNA-binding function of Mov10 is responsible for its antiviral effect. Decreasing Mov10 protein expression levels decreased HCV replication and infection levels. Our data reveal a complex balance between Mov10 and HCV. In Chapter IV we studied several aspects of HCV. (i) We discovered two novel small molecule inhibitors of the HCV helicase that have antiviral function. (ii) We discovered that Dcp2 is a novel HCV host restriction factor that can block HCV replication, and (iii) we provide insights into the mechanism(s) of action of approved and clinically advanced direct-acting antiviral agents (DAAs).

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