Multicomponent reactions in the synthesis of antiviral compounds

Background: Multicomponent reactions are one-pot processes for the synthesis of highly functionalized hetero-cyclic and hetero-acyclic compounds, often endowed with biological activity. Objective: Multicomponent reactions are considered green processes with high atom economy. In addition, they present advantages compared to the classic synthetic methods such as high efficiency and low wastes production. Method: In these reactions two or more reagents are combined together in the same flask to yield a product containing almost all the atoms of the starting materials. Results: The scope of this review is to present an overview of the application of multicomponent reactions in the synthesis of compounds endowed with antiviral activity. The syntheses are classified depending on the viral target. Conclusion: Multicomponent reactions can be applied to all the stages of the drug discovery and development process making them very useful in the search for new agents active against emerging (viral) pathogens.

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Recent advance in ester synthesis by Multi Component Reactions (MCRs): A Review

Current Organic Chemistry ◽

10.2174/1385272825666210111111805 ◽

2021 ◽

Vol 25 ◽

Author(s):

Dhaval B. Patel ◽

Jagruti A. Parmar ◽

Siddharth S. Patel ◽

Unnati J. Naik ◽

Hitesh D. Patel

Keyword(s):

Multicomponent Reactions ◽

Medicinal Chemistry ◽

Reaction Times ◽

Synthetic Methods ◽

Ester Synthesis ◽

One Pot ◽

Wide Range ◽

Recent Developments ◽

Ester Linkage ◽

The One

: The synthesis of ester containing heterocyclic compounds via multicomponent reaction is one of the most preferable process in the synthetic organic chemistry and medicinal chemistry. Compounds containing ester linkage have a wide range of biological application in the pharmaceutical field. Therefore, many method have been developed for the synthesis of these type of derivatives. However, some of them are carried out in the presence of toxic solvents and catalysts, with lower yields, longer reaction times, low selectivities and by-products. Thus, the development of new synthetic methods for the ester synthesis is required in the medicinal chemistry. As we know, multicomponent reactions (MCRs) are a powerful tool towards the one-pot ester synthesis, so in this article we have reviewed the recent developments in ester synthesis. This work covers selected explanation of methods via multicomponent reactions to explore the methodological development in ester synthesis.

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Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent-Free Conditions

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666190325120715 ◽

2019 ◽

Vol 22 (2) ◽

pp. 123-128

Author(s):

Setareh Habibzadeh ◽

Hassan Ghasemnejad-Bosra ◽

Mina Haghdadi ◽

Soheila Heydari-Parastar

Keyword(s):

Carboxylic Acid ◽

Fe3o4 Nanoparticles ◽

High Efficiency ◽

Reaction Times ◽

Chlorosulfonic Acid ◽

Aromatic Aldehydes ◽

Solvent Free ◽

Magnetic Nanocatalyst ◽

One Pot ◽

Solvent Free Conditions

Background: In this study, we developed a convenient methodology for the synthesis of coumarin linked to pyrazolines and pyrano [2,3-h] coumarins linked to 3-(1,5-diphenyl-4,5- dihydro-1H-pyrazol-3-yl)-chromen-2-one derivatives using Chlorosulfonic acid supported Piperidine-4-carboxylic acid (PPCA) functionalized Fe3O4 nanoparticles (Fe3O4-PPCA) catalyst. Materials and Methods:: Fe3O4-PPCA was investigated as an efficient and magnetically recoverable Nanocatalyst for the one-pot synthesis of substituted coumarins from the reaction of coumarin with a variety of aromatic aldehydes in high to excellent yield at room temperature under solvent-free conditions. The magnetic nanocatalyst can be easily recovered by applying an external magnet device and reused for at least 10 reaction runs without considerable loss of reactivity. Results and Conclusion: The advantages of this protocol are the use of commercially available materials, simple and an inexpensive procedure, easy separation, and an eco-friendly procedure, and it shows good reaction times, good to high yields, inexpensive and practicability procedure, and high efficiency.

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Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/13862073113169990046 ◽

2013 ◽

Vol 16 (10) ◽

pp. 788-790

Author(s):

Zinatossadat Hossaini ◽

Samereh Seyfi ◽

Faramarz Rostami-Charati ◽

Mehdi Ghambarian

Keyword(s):

Multicomponent Reactions ◽

Efficient Synthesis ◽

One Pot ◽

Imidazole Derivatives ◽

New Class

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Recent Developments on Five-Component Reactions

Molecules ◽

10.3390/molecules26071986 ◽

2021 ◽

Vol 26 (7) ◽

pp. 1986

Author(s):

Xiaoming Ma ◽

Sanjun Zhi ◽

Wei Zhang

Keyword(s):

Multicomponent Reactions ◽

High Efficiency ◽

Review Article ◽

Reaction Centers ◽

Synthetic Approach ◽

Recent Developments

Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.

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