Bile Acids as Novel Pharmacological Agents: the Interplay between Gene Polymorphisms, Epigenetic Factors and Drug Response

2016 ◽  
Vol 22 (999) ◽  
pp. 1-1 ◽  
Author(s):  
Nebojša Pavlović ◽  
Bojan Stanimirov ◽  
Momir Mikov
Keyword(s):  
Bile Acids ◽  
Gene Polymorphisms ◽  
Drug Response ◽  
Epigenetic Factors ◽  
Pharmacological Agents

Predicting drug response and toxicity based on gene polymorphisms

2005 ◽  
Vol 54 (3) ◽  
pp. 171-196 ◽  
Author(s):  
Jacques Robert ◽  
Valérie Le Morvan ◽  
Denis Smith ◽  
Philippe Pourquier ◽  
Jacques Bonnet
Keyword(s):  
Gene Polymorphisms ◽  
Drug Response

Enhancement of the Urinary Excretion of Non-Sulphated and Sulphated Radioactive Bile Acids by Sodium Acetate in the Bile Duct Obstructed Rat

1985 ◽  
Vol 68 (1) ◽  
pp. 63-70 ◽  
Author(s):  
A. Chitranukroh ◽  
G. Taggart ◽  
B. H. Billing
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Urinary Excretion ◽  
Glomerular Filtration ◽  
Bile Acids ◽  
Renal Clearance ◽  
Sodium Acetate ◽  
Pharmacological Agents ◽  
Renal Clearances ◽  
Inhibition Studies

1. The renal clearances of [14C]glycocholate, [14C]taurocholate and [3H]glycochenodeoxycholate-3-sulphate were determined in bile duct obstructed rats. 2. Comparisons of the bile acid clearances with glomerular filtration rates (GFR) indicate that most of the filtered bile acids are reabsorbed. 3. Inhibition studies with p-aminohippurate (PAH) and probenecid suggest that a proportion of the bile acids in urine is secreted. 4. Attempts were made to increase the renal clearance of the bile acids by the administration of pharmacological agents. 5. An infusion of sodium acetate (0.3 mol/l) increased the clearance of the radioactive bile acids and augmented the urinary excretion of endogenous 3α-hydroxy bile acids and reduced their concentration in plasma.

Mannan-binding lectin gene polymorphisms in ulcerative colitis and Crohn's disease

2001 ◽  
Vol 120 (5) ◽  
pp. A459-A459
Author(s):  
A RECTOR ◽  
P LEMEY ◽  
W LAFFUT ◽  
E KEYAERTS ◽  
F STRUYF ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gene Polymorphisms ◽  
Lectin Gene ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Influence of pepsinogen gene polymorphisms on serum pepsinogen

1997 ◽  
Vol 61 (2) ◽  
pp. 93-97 ◽  
Author(s):  
Z. YAMAGATA ◽  
Y. ZHANG ◽  
S. SHINOZAKI ◽  
T. MIYAMURA ◽  
S. IIJIMA ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Serum Pepsinogen
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