Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles

2021 ◽  
Vol 25 ◽  
Author(s):  
Daiana Portella Franco ◽  
Lucas Caruso ◽  
Nathalia Fonseca Nadur ◽  
Thiago Moreira Pereira ◽  
Renata Barbosa Lacerda ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Recent Advances

: Triazoles are five-membered aromatic heterocyclics, which could exist in two isosteric forms (1,2,3-triazoles and 1,2,4-triazoles) presenting huge applications in medicinal, agricultural, supramolecular and materials sciences. The drugs fluconazole, ribavirin, cefatrizine and tazobactam, and the herbicides cafenstrole and metosulam are famous examples of triazoles. The aim of this review is to present the main recent examples of Microwave-Assisted Organic Synthesis (MAOS) applied for the synthesis end functionalization of 1,4- and 1,5-disubstituted-1,2,3-triazoles, 1,2,4-triazoles, 3-amino-1,2,4-triazoles, 1,2,4-triazol-3-one and 1,2,4-triazol-3-thiol derivatives. Worth of noting, despite some previous reviews about triazole synthesis, none of them focused exclusively on the importance of MAOS technic in the obtention and derivatization of these compounds.

scholarly journals Microwave Assisted Synthesis of Organic Compounds and Nanomaterials

2021 ◽  
Author(s):  
Anjali Jha
Keyword(s):  
Green Chemistry ◽  
Organic Synthesis ◽  
Electric Fields ◽  
Chemical Reactions ◽  
Dipole Moments ◽  
Electric Heating ◽  
Microwave Assisted Synthesis ◽  
Microwave Chemistry ◽  
Microwave Assisted ◽  
Promising Area

In the Conventional laboratory or industry heating technique involve Bunsen burner, heating mental/hot plates and electric heating ovens. To produce a variety of useful compounds for betterment of mankind, the Microwave Chemistry was introduced in year 1955 and finds a place in one of the Green chemistry method. In Microwave chemistry is the science of applying microwave radiation to chemical reactions. Microwaves act as high frequency electric fields and will generally heat any material containing mobile electric charges, such as polar molecules in a solvent or conducting ions in a solid. Polar solvents are heated as their component molecules are forced to rotate with the field and lose energy in collisions i.e. the dipole moments of molecules are important in order to proceed with the chemical reactions in this method. It can be termed as microwave-assisted organic synthesis (MAOS), Microwave-Enhanced Chemistry (MEC) or Microwave-organic Reaction Enhancement synthesis (MORE). Microwave-Assisted Syntheses is a promising area of modern Green Chemistry could be adopted to save the earth.

Application of microwave-assisted heterogeneous catalysis in sustainable synthesis design

2017 ◽  
Vol 19 (16) ◽  
pp. 3729-3751 ◽  
Author(s):  
Anne Kokel ◽  
Christian Schäfer ◽  
Béla Török
Keyword(s):  
Energy Efficiency ◽  
Heterogeneous Catalysis ◽  
Scale Up ◽  
Catalytic Synthesis ◽  
Microwave Assisted Synthesis ◽  
Heterogeneous Catalytic ◽  
Microwave Assisted ◽  
Synthesis Design ◽  
Recent Advances

Recent advances in the application of microwave-assisted heterogeneous catalytic synthesis approaches are reviewed with additional inputs on the energy efficiency and scale-up of microwave-assisted synthesis.

scholarly journals Microwave-Assisted Synthesis and Properties of Novel Hexaazatrinaphthylene Dendritic Scaffolds

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5038
Author(s):  
Daniel García Velázquez ◽  
Rafael Luque ◽  
Ángel Gutiérrez Ravelo
Keyword(s):  
Cyclic Voltammetry ◽  
Organic Synthesis ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Water Soluble ◽  
Microwave Assisted Synthesis ◽  
1H And 13C Nmr ◽  
Maldi Tof Ms ◽  
Microwave Assisted ◽  
Tof Ms

A novel family of water-soluble π-conjugated hexaazatrinaphthylenes-based dendritic architectures constructed by hexaketocyclohexane and 1,2,4,5-benzenetetramine units is developed in a microwave-assisted organic synthesis (MAOS) approach. The structures and purity of these compounds are verified by 1H and 13C-NMR, MALDI-TOF MS, UV-vis, elemental analysis, DSC, AFM, STM and cyclic voltammetry.

Microwave Assisted Organic Synthesis of Heterocycles in Aqueous Media: Recent Advances in Medicinal Chemistry

2016 ◽  
Vol 12 (8) ◽  
pp. 720-732 ◽  
Author(s):  
Francesco Frecentese ◽  
Irene Saccone ◽  
Giuseppe Caliendo ◽  
Angela Corvino ◽  
Ferdinando Fiorino ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Aqueous Media ◽  
Microwave Assisted ◽  
Recent Advances

The Microwave Assisted Synthesis of Imine Derivative Ligands for Nickel(II) Complex as Catalyst Precursors in Glucose Conversion to Sorbitol

2019 ◽  
Vol 811 ◽  
pp. 47-54
Author(s):  
Deana Wahyuningrum ◽  
Irma Mulyani ◽  
Ray Putra Prajnamitra
Keyword(s):  
Particle Size ◽  
Catalytic Activity ◽  
Organic Synthesis ◽  
Average Particle Size ◽  
Microwave Assisted Synthesis ◽  
Average Particle ◽  
Calcination Process ◽  
Microwave Assisted ◽  
Good Catalytic Activity ◽  
L1 And L2

Two imine derivative ligands, L1 and L2, have been synthesized using the microwave assisted organic synthesis (MAOS) method from the reaction between bibenzoyl and L-tryptophan and L-Histidine, respectively. The ligands were further transformed into two nickel(II) complex, C1 and C2, as the precursors of catalysts in glucose conversion to sorbitol. The two NiO/SiO2 catalysts, K1 and K2, have been generated through the calcination process of complex C1 and C2, respectively, which were previously impregnated into silica. The K1 catalyst with average particle size of 5 nm shows good catalytic activity, with no presence of any nickel leached into the solution, and has successfully converted 21.99% of glucose into sorbitol. The K2 catalyst with average particle size of 10 nm also shows good catalytic activity and has successfully converted 32.30% of glucose into sorbitol, although it shows the presence of leached nickel.

Microwave Assisted Catalyst-free Synthesis of Bioactive Heterocycles

2020 ◽  
Vol 7 (1) ◽  
pp. 5-22 ◽  
Author(s):  
Bubun Banerjee ◽  
Gurpreet Kaur
Keyword(s):  
Microwave Assisted Synthesis ◽  
Reaction Conditions ◽  
Microwave Assisted ◽  
Catalyst Free ◽  
Recent Advances ◽  
Bioactive Heterocycles

This review deals with the recent advances on the microwave-assisted synthesis of bioactive heterocycles without using any catalyst under various reaction conditions. Synthesis of various biologically promising N-heterocycles, O-heterocycles, S-heterocycles, N as well as O- or S-heterocycles reported so far under catalyst-free microwave-irradiated conditions are discussed in this review.

Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives

Heterocycles ◽  
2021 ◽  
Vol 103 (1) ◽  
pp. 65
Author(s):  
Gopinathan Anilkumar ◽  
Thaipparambil Aneeja ◽  
C M A Afsina
Keyword(s):  
Microwave Assisted Synthesis ◽  
Indole Derivatives ◽  
Microwave Assisted ◽  
Recent Advances

scholarly journals Microwave Assisted Synthesis, Characterization and Anti-Tubercular Activity of 4-Quinolylhydrazone

2019 ◽  
Vol 9 (4-A) ◽  
pp. 95-97
Author(s):  
Chandrakant V. Bisen ◽  
M. R. Patle ◽  
P.K. Rahangdale
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Melting Point ◽  
Organic Synthesis ◽  
Mass Spectroscopy ◽  
Analytical Techniques ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Modern Analytical

A series of 4-quinolylhydrazone derivatives was synthesized by reaction of 4-quinolylhydrazine and various substituted carboxaldehyde out of that most of the derivatives show significant antitubercular properties. The microwave assisted organic synthesis was applied to synthesize a series of 4-quinolylhydrazone derivatives. The characterizations of newly synthesized derivatives were done by modern analytical techniques like digital melting point apparatus, IR, NMR and mass spectroscopy. Keywords: Mycobacterium tuberculosis, Hydrazone, Quinoline, Carboxaldehyde.

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