Role of P-Glycoprotein in the Intestinal Absorption of Tanshinone IIA, a Major Active Ingredient in the Root of Salvia miltiorrhiza Bunge

2007 ◽  
Vol 8 (4) ◽  
pp. 325-340 ◽  
Author(s):  
Xi-Yong Yu ◽  
Shu-Guang Lin ◽  
Zhi-Wei Zhou ◽  
Xiao Chen ◽  
Jun Liang ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Active Ingredient ◽  
Salvia Miltiorrhiza ◽  
Tanshinone Iia ◽  
Salvia Miltiorrhiza Bunge ◽  
P Glycoprotein

Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocyte injury via lncRNA AK003290/miR-124-5p signaling

2020 ◽  
Author(s):  
Liye Chen ◽  
Lili Wei ◽  
Qiongyang Yu ◽  
Haozhe Shi ◽  
George Liu
Keyword(s):  
Mitochondrial Membrane ◽  
Salvia Miltiorrhiza ◽  
Underlying Mechanism ◽  
Protective Role ◽  
Tanshinone Iia ◽  
Salvia Miltiorrhiza Bunge ◽  
Pharmacological Activities ◽  
Heavy Burden ◽  
Induced Apoptosis

Abstract Background: Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a major active compound, extracted from Salvia miltiorrhiza Bunge, that possesses various pharmacological activities. The aim of the present study was to investigate the role of TSA in AMI and its underlying mechanism of action.Results: We have shown that TSA decreased the apoptosis rate, the amount of LDH, MDA as well as ROS of cardiomyocytes. Meantime, it elevated mitochondrial membrane potential (MMP) which was decreased by H/R treatment. It was also determined that miR-124-5p targets AK003290 directly. TSA up-regulated the expression of AK003290 and its function can be reversed by knock down of AK003290 as well as miR-124-5p overexpression.Conclusion: TSA exerts the protective role against H/R induced apoptosis, oxidative and MMP loss of cardiomyocytes via regulating AK003290 and miR-124-5p signaling.

scholarly journals Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocyte injury via lncRNA AK003290/miR-124-5p signaling

2020 ◽  
Author(s):  
Liye Chen ◽  
Lili Wei ◽  
Qiongyang Yu ◽  
Haozhe Shi ◽  
George Liu
Keyword(s):  
Mitochondrial Membrane ◽  
Salvia Miltiorrhiza ◽  
Underlying Mechanism ◽  
Protective Role ◽  
Tanshinone Iia ◽  
Salvia Miltiorrhiza Bunge ◽  
Pharmacological Activities ◽  
Heavy Burden ◽  
Induced Apoptosis

Abstract Background: Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a major active compound, extracted from Salvia miltiorrhiza Bunge, that possesses various pharmacological activities. The aim of the present study was to investigate the role of TSA in AMI and its underlying mechanism of action.Results: We have shown that TSA decreased the apoptosis rate, the amount of LDH, MDA as well as ROS of cardiomyocytes. Meantime, it elevated mitochondrial membrane potential (MMP) which was decreased by H/R treatment. It was also determined that miR-124-5p targets AK003290 directly. TSA up-regulated the expression of AK003290 and its function can be reversed by knock down of AK003290 as well as miR-124-5p overexpression.Conclusion: TSA exerts the protective role against H/R induced apoptosis, oxidative and MMP loss of cardiomyocytes via regulating AK003290 and miR-124-5p signaling.

Quinidine as a Probe for the Role of P-Glycoprotein in the Intestinal Absorption and Clinical Effects of Fentanyl

2004 ◽  
Vol 44 (3) ◽  
pp. 224-233 ◽  
Author(s):  
Evan D. Kharasch ◽  
Christine Hoffer ◽  
T. Gul Altuntas ◽  
Dale Whittington
Keyword(s):  
Intestinal Absorption ◽  
Clinical Effects ◽  
P Glycoprotein
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