Recent advances in biotransformation by Cunninghamella species

: The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds. Cunninghamella spp is among the fungal models most widely used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January 2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new tools for further studies in this scope.

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Zoledronic acid in cancer patients with bone metastases: Results of Phase I and II trials

Seminars in Oncology ◽

10.1053/sonc.2001.24157 ◽

2001 ◽

Vol 28 (2C) ◽

pp. 25-34 ◽

Cited By ~ 1

Author(s):

James R. Berenson

Keyword(s):

Zoledronic Acid ◽

Phase I ◽

Bone Metastases ◽

Cancer Patients ◽

Phase I And Ii

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Evaluation of Dredged Material Disposal and Management for Appomattox River Federal Navigation Channel, Petersburg, Virginia. Phase I and II - Environmental and Engineering Studies

10.21236/ada408172 ◽

2002 ◽

Author(s):

Roy Wade ◽

Richard A. Price ◽

John W. Simmers ◽

Cynthia Price ◽

Michael R. Palermo

Keyword(s):

Phase I ◽

Dredged Material ◽

Engineering Studies ◽

Navigation Channel ◽

Dredged Material Disposal ◽

Phase I And Ii

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Phase I and II Archaeological Investigations at Shaw Air Force Base and the Poinsett Electronic Combat Range, Sumter County, South Carolina

10.21236/ada433130 ◽

2005 ◽

Author(s):

Alvin J. Banguilan ◽

John S. Cable ◽

Charles E. Cantley ◽

Leslie Raymer ◽

Victoria Dabir-Banguilan

Keyword(s):

South Carolina ◽

Phase I ◽

Air Force ◽

Air Force Base ◽

Phase I And Ii

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Fungal Treatment for the Valorization of Technical Soda Lignin

Journal of Fungi ◽

10.3390/jof7010039 ◽

2021 ◽

Vol 7 (1) ◽

pp. 39

Author(s):

Mariane Daou ◽

Clementina Farfan Soto ◽

Amel Majira ◽

Laurent Cézard ◽

Betty Cottyn ◽

...

Keyword(s):

Filamentous Fungi ◽

Structural Changes ◽

Molar Mass ◽

Glycoside Hydrolases ◽

Fungal Treatment ◽

Industrial Transformation ◽

Pycnoporus Sanguineus ◽

Technical Lignin ◽

Soda Lignin ◽

Technical Lignins

Technical lignins produced as a by-product in biorefinery processes represent a potential source of renewable carbon. In consideration of the possibilities of the industrial transformation of this substrate into various valuable bio-based molecules, the biological deconstruction of a technical soda lignin by filamentous fungi was investigated. The ability of three basidiomycetes (Polyporus brumalis, Pycnoporus sanguineus and Leiotrametes menziesii) to modify this material, the resultant structural and chemical changes, and the secreted proteins during growth on this substrate were investigated. The three fungi could grow on the technical lignin alone, and the growth rate increased when the media were supplemented with glucose or maltose. The proteomic analysis of the culture supernatants after three days of growth revealed the secretion of numerous Carbohydrate-Active Enzymes (CAZymes). The secretomic profiles varied widely between the strains and the presence of technical lignin alone triggered the early secretion of many lignin-acting oxidoreductases. The secretomes were notably rich in glycoside hydrolases and H2O2-producing auxiliary activity enzymes with copper radical oxidases being induced on lignin for all strains. The lignin treatment by fungi modified both the soluble and insoluble lignin fractions. A significant decrease in the amount of soluble higher molar mass compounds was observed in the case of P. sanguineus. This strain was also responsible for the modification of the lower molar mass compounds of the lignin insoluble fraction and a 40% decrease in the thioacidolysis yield. The similarity in the activities of P. sanguineus and P. brumalis in modifying the functional groups of the technical lignin were observed, the results suggest that the lignin has undergone structural changes, or at least changes in its composition, and pave the route for the utilization of filamentous fungi to functionalize technical lignins and produce the enzymes of interest for biorefinery applications.

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Osteosarcoma Pathogenesis Leads the Way to New Target Treatments

International Journal of Molecular Sciences ◽

10.3390/ijms22020813 ◽

2021 ◽

Vol 22 (2) ◽

pp. 813

Author(s):

Isabel Fernandes ◽

Cecília Melo-Alvim ◽

Raquel Lopes-Brás ◽

Miguel Esperança-Martins ◽

Luís Costa

Keyword(s):

Clinical Trials ◽

Phase I ◽

Poor Prognosis ◽

Therapeutic Targets ◽

Rare Condition ◽

Basic Research ◽

Metastatic Setting ◽

Phase I And Ii ◽

The Way

Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic research has enabled a better understanding of OS pathogenesis and the discovery of new potential therapeutic targets. Phase I and II clinical trials are already ongoing, with some promising results for these patients. This article reviews OS pathogenesis and new potential therapeutic targets.

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