EGFR Transactivation by Peptide G Protein-Coupled Receptors in Cancer

2016 ◽  
Vol 17 (5) ◽  
pp. 520-528 ◽  
Author(s):  
Terry W. Moody ◽  
Bernardo Nuche-Berenguer ◽  
Taichi Nakamura ◽  
Robert T. Jensen
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Egfr Transactivation ◽  
G Protein Coupled ◽  
Peptide G

ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors

2006 ◽  
Vol 291 (1) ◽  
pp. C1-C10 ◽  
Author(s):  
Haruhiko Ohtsu ◽  
Peter J. Dempsey ◽  
Satoru Eguchi
Keyword(s):  
G Protein ◽  
Egf Receptor ◽  
Current Knowledge ◽  
G Protein Coupled Receptors ◽  
Surface Proteins ◽  
Egf Receptors ◽  
Cellular Functions ◽  
Egfr Transactivation ◽  
And Migration ◽  
G Protein Coupled

A disintegrin and metalloprotease (ADAM) is a membrane-anchored metalloprotease implicated in the ectodomain shedding of cell surface proteins, including the ligands for epidermal growth factor (EGF) receptors (EGFR)/ErbB. It has been well documented that the transactivation of the EGFR plays critical roles for many cellular functions, such as proliferation and migration mediated through multiple G protein-coupled receptors (GPCRs). Recent accumulating evidence has suggested that ADAMs are the key metalloproteases activated by several GPCR agonists to produce a mature EGFR ligand leading to the EGFR transactivation. In this review, we describe the current knowledge on ADAMs implicated in mediating EGFR transactivation. The major focus of the review will be on the possible upstream mechanisms of ADAM activation by GPCRs as well as downstream signal transduction and the pathophysiological significances of ADAM-dependent EGFR transactivation.

EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors

2002 ◽  
Vol 283 (2) ◽  
pp. C446-C455 ◽  
Author(s):  
Laure Voisin ◽  
Sylvain Foisy ◽  
Edith Giasson ◽  
Chantal Lambert ◽  
Pierre Moreau ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
G Protein ◽  
Muscle Cells ◽  
G Protein Coupled Receptors ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Egfr Transactivation ◽  
G Protein Coupled

The epidermal growth factor receptor (EGFR) was recently identified as a signal transducer of G protein-coupled receptors (GPCRs). In this study, we have examined the contribution of EGFR transactivation to the growth-promoting effect of GPCRs on vascular smooth muscle cells. Activation of the Gq-coupled ANG II receptor or Gi-coupled lysophosphatidic acid receptor resulted in increased tyrosine phosphorylation and activation of EGFR. Specific inhibition of EGFR kinase activity by tyrphostin AG-1478 or expression of a dominant-negative EGFR mutant abolished this response. Importantly, inhibition of EGFR function strongly attenuated the global stimulation of protein synthesis by GPCR agonists in vitro in cultured aortic smooth muscle cells and in vivo in the rat aorta and in small resistance arteries. The growth inhibition was associated with a marked reduction of extracellular signal-regulated kinase and phosphoinositide 3-kinase pathway activity and the resulting suppression of eukaryotic translation initiation factor 4E and 4E binding protein 1 phosphorylation. Our results demonstrate that EGFR transactivation is a physiologically relevant action of GPCRs linked to translational control and protein synthesis.

scholarly journals Exploiting cancer’s phenotypic guise against itself: targeting ectopically expressed peptide G-protein coupled receptors for lung cancer therapy

Oncotarget ◽  
2017 ◽  
Vol 8 (61) ◽  
pp. 104615-104637 ◽  
Author(s):  
Mahjabin Khan ◽  
Tao Huang ◽  
Cheng-Yuan Lin ◽  
Jiang Wu ◽  
Bao-Min Fan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Lung Cancer Therapy ◽  
G Protein Coupled ◽  
Peptide G

Peptide and non-peptide G-protein coupled receptors (GPCRs) in skeletal muscle

Peptides ◽  
2005 ◽  
Vol 26 (8) ◽  
pp. 1528-1536 ◽  
Author(s):  
Gaël Jean-Baptiste ◽  
Zhao Yang ◽  
Chamel Khoury ◽  
Sabrina Gaudio ◽  
Michael T. Greenwood
Keyword(s):  
Skeletal Muscle ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled ◽  
Peptide G

Peptide G protein-coupled receptors meet at Erice

1998 ◽  
Vol 19 (9) ◽  
pp. 343-346 ◽  
Author(s):  
Nigel W. Bunnett ◽  
Michel Bouvier ◽  
Antonio De Blasi
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled ◽  
Peptide G
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