Editorial (Hot Topic: Antioxidant Heterocyclic Compounds in Drug Discovery and Medicinal Chemistry)

2013 ◽  
Vol 13 (3) ◽  
pp. 317-317
Author(s):  
Sibel Suzen ◽  
Luciano Saso
Keyword(s):  
Drug Discovery ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry

scholarly journals THE INFLUENCES OF POWER VARIATIONS ON SELECTIVITY OF SYNTHESIS REACTION OF 2’-HYDROXYCHALCONE ANALOGUE UNDER MICROWAVE IRRADIATION

Molekul ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. 299 ◽  
Author(s):  
Adel Zamri ◽  
Hilwan Yuda Teruna ◽  
Ihsan Ikhtiarudin
Keyword(s):  
Drug Discovery ◽  
Microwave Irradiation ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Synthesis Reaction ◽  
Material Synthesis ◽  
Power Variation ◽  
Material Chemistry ◽  
Irradiation Power

Some 2’-hydroxychalcone analogues have been widely used as an intermediate to synthesize various heterocyclic compounds, such as flavanones, flavanonols, flavones, flavonols and others. The heterocyclic compounds are also known to have a variety of interesting bioactivities in the medicinal chemistry and also have potency to be applied  in material chemistry including in industry. Therefore, 2’-hydroxychalcone analogues are often synthesized by researchers as intermediate, both in research associated with drug discovery and material synthesis. The aim of this study is to investigate the effect of microwave irradiation power variations on the selectivity of reaction of 2’-hydroxychalcone analogue synthesis. The variations of power that have been used in this study were 100, 180, 300 and 450 W with using a domestic microwave. Based on the study, we conclude that the power variation of microwave irradiationwere proven to effect the selectivity of synthesis reaction. In this study, the most suitable irradiation power to be applied on this synthesis is 180 W.

scholarly journals A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles

2018 ◽  
Vol 34 (4) ◽  
pp. 1670-1700 ◽  
Author(s):  
Iqbal Azad ◽  
Firoj Hassan ◽  
Mohammad `Saquib ◽  
Naseem Ahmad ◽  
Abdul Rahman Khan ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Critical Review ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Structural Motif ◽  
Aromatic Molecule ◽  
Multicomponent Synthesis

Nitrogen containing heterocyclic compounds are biologically significant molecules. This is especially true for pyrrole a five membered nitrogen containing aromatic molecule, which is present as a key structural motif in a large number of drugs and lead molecules. This review aims to provide an overview of the multi-component reaction (MCR) based methodologies used for the synthesis of pyrrole and its derivatives, focusing particularly on eco-friendly methods that avoid the use of hazardous reagents, solvents and catalysts are deemed especially relevant to the disciplines of medicinal chemistry and drug discovery.

Oxazole-Based Compounds As Anticancer Agents

2020 ◽  
Vol 26 (41) ◽  
pp. 7337-7371 ◽  
Author(s):  
Maria A. Chiacchio ◽  
Giuseppe Lanza ◽  
Ugo Chiacchio ◽  
Salvatore V. Giofrè ◽  
Roberto Romeo ◽  
...  
Keyword(s):  
Cancer Research ◽  
Drug Discovery ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Chemical Diversity ◽  
Biologically Active ◽  
New Drugs ◽  
The Core ◽  
Anti Cancer ◽  
Biologically Active Derivatives

: Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.

Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

2014 ◽  
Vol 14 (7) ◽  
pp. 941-951 ◽  
Author(s):  
Gregory Landelle ◽  
Armen Panossian ◽  
Frederic Leroux
Keyword(s):  
Drug Discovery ◽  
Medicinal Chemistry

Secondary Metabolites of Plant Origin containing Carbazole as Lead Molecule: A Review

2019 ◽  
Vol 05 ◽  
Author(s):  
Atul Sharma ◽  
Devender Pathak
Keyword(s):  
Drug Discovery ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Chemical Compounds ◽  
Lethal Effect ◽  
Chemical Diversity ◽  
Chemical Transformations ◽  
Pharmacological Effects ◽  
Structural Class ◽  
Biological Targets

Keeping this fact that study of a body is biology but life is all about chemicals and chemical transformations, many medicinal chemist start research in finding new and novel chemical compounds which having pharmacological activities. Most of those chemical compounds which are having active pharmacological effects are heterocyclic compounds. Heterocyclic compounds clutch a particular place among pharmaceutically active natural and synthetic compounds. The ability to serve both as biomimetics and reactive pharmacophores of heterocyclic nuclei is incredible and it has principally contributed to their unique value as traditional key elements of numerous drugs. These heterocyclic nuclei offer a huge area for new lead molecules for drug discovery and for generation of activity relationships with biological targets to enhance pharmacological effects. For these reasons, it is not surprising that this structural class has received special attention in drug discovery. The hydrogen bond acceptors and donors arranged in a manner of a semi-rigid skeleton in heterocyclic rings and therefore they can present a varied display of significant pharmacophores. Lead identification and optimization of drug target probable can be achieved by generation of chemical diversity produced by derivatization of heterocyclic pharmacophores with different groups or substituents. A tricyclic carbazole nucleus is an integral part of naturally occurring alkaloids and synthetic derivatives, possessing various potential biological activities such as anticancer, antimicrobial and antiviral. Binding mechanism of carbazole with target receptor as a molecule or fused molecule exhibits the potential lethal effect.

Sign in / Sign up

Export Citation Format

Share Document