scholarly journals Association between Vitamin D Levels and Nonalcoholic Fatty Liver Disease: Potential Confounding Variables

2019 ◽  
Vol 19 (4) ◽  
pp. 310-332 ◽  
Author(s):  
Lucia Pacifico ◽  
John F. Osborn ◽  
Enea Bonci ◽  
Pasquale Pierimarchi ◽  
Claudio Chiesa
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Vitamin D Levels ◽  
Confounding Variables

scholarly journals The Association between Vitamin D and Nonalcoholic Fatty Liver Disease Assessed by Controlled Attenuation Parameter

2021 ◽  
Vol 10 (12) ◽  
pp. 2611
Author(s):  
Nam Ju Heo ◽  
Hyo Eun Park ◽  
Ji Won Yoon ◽  
Min-Sun Kwak ◽  
Jong In Yang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Serum Vitamin ◽  
Controlled Attenuation Parameter ◽  
Nonalcoholic Fatty Liver ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: An association between nonalcoholic fatty liver disease (NAFLD) and low vitamin D levels has been suggested. We investigated the relationship between vitamin D and NAFLD assessed by controlled attenuation parameter (CAP). Methods: We conducted a retrospective cohort study of apparently healthy subjects who underwent Fibroscan during health screening tests. NAFLD was diagnosed using CAP values. Results: Among the 1202 subjects (mean age 57.2 years, 60.6% male), 630 (52.4%) subjects had NAFLD with CAP ≥ 248 dB/m. Multivariable analysis was conducted after adjusting for metabolic risk factors including diabetes, hypertension, hypercholesterolemia, body mass index, high-density lipoprotein cholesterol, triglyceride and smoking. Higher vitamin D levels showed a lower risk of NAFLD compared to the lowest quartile of vitamin D in a dose-dependent manner (OR 0.68, 95% CI 0.47–1.00 in Q2 vs. Q1; OR 0.65, 95% CI 0.44–0.94 in Q3 vs. Q1; and OR 0.64, 95% CI 0.44–0.94 in Q4 vs. Q1). The highest quartile of vitamin D showed a decreased risk of a severe grade of steatosis (CAP ≥ 302 dB/m) compared to the lowest quartile (OR 0.52, 95% CI 0.31–0.87 in Q4 vs. Q1). Conclusions: Higher levels of serum vitamin D were associated with a decreased risk of CAP-defined NAFLD, compared to low levels of serum vitamin D. The association between NAFLD and vitamin D suggests that vitamin D may exert a protective role against NAFLD.

scholarly journals Patients with Nonalcoholic Fatty Liver Disease Have a Low Response Rate to Vitamin D Supplementation

2017 ◽  
Vol 147 (10) ◽  
pp. 1938-1946 ◽  
Author(s):  
Jaividhya Dasarathy ◽  
Rony Varghese ◽  
Abram Feldman ◽  
Amer Khiyami ◽  
Arthur J McCullough ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Response Rate ◽  
Vitamin D Supplementation ◽  
Nonalcoholic Fatty Liver

scholarly journals Vitamin D deficiency: prevalence and association with liver disease severity in pediatric nonalcoholic fatty liver disease

2019 ◽  
Vol 74 (3) ◽  
pp. 427-435 ◽  
Author(s):  
Toshifumi Yodoshi ◽  
Sarah Orkin ◽  
Ana Catalina Arce-Clachar ◽  
Kristin Bramlage ◽  
Chunyan Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

2014 ◽  
Vol 170 (4) ◽  
pp. 547-553 ◽  
Author(s):  
Valerio Nobili ◽  
Valentina Giorgio ◽  
Daniela Liccardo ◽  
Giorgio Bedogni ◽  
Giuseppe Morino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Linear Regression ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Research Network ◽  
Mineral Density ◽  
Serum Aminotransferase ◽  
Nonalcoholic Fatty Liver

ObjectiveTo investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD).Subjects and methodsIn this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with persistently elevated serum aminotransferase levels and diffusely hyperechogenic liver on ultrasonography were selected for liver biopsy. Nonalcoholic steatohepatitis (NASH) and fibrosis were histologically diagnosed using NAFLD Clinical Research Network (CRN) criteria. The plasma levels of 25-OH-VD were measured by HPLC. Bone mineral density (BMD) of lumbar spine was evaluated by dual-energy X-ray absorptiometry. Multiple linear regression analysis was used to evaluate the association between 25-OH-VD levels and the predictors of interest after correction for age, gender, waist circumference, BMI, and other potential confounders.ResultsThe children (64% males) were aged 8–18 years, and their median BMI was 2.45 SDS. Both parathyroid hormone levels and BMD were within the normal range. All cases of fibrosis were detected in children with NASH. On multivariable linear regression with correction for age, gender, and BMI, 25-OH-VD levels were found to be 9 (95% CI 12–6) ng/ml lower in children with NASH than in those without NASH (P<0.001) and 9 (12–6) ng/ml lower in children with stage 1 fibrosis than in those with stage 0 fibrosis and 9 (13–6) ng/ml lower in children with stage 2 than in those with stage 0 fibrosis (P<0.001 for both).ConclusionVD levels are inversely associated with NASH and fibrosis in children with NAFLD.

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