Molecular Concept of Diabetic Wound Healing: Effective Role of Herbal Remedies

The incidence of diabetes mellitus (DM) is on the rise, worldwide. One of the main complications in DM is delayed wound healing and it often requires amputation. Various drugs were used to treat DM but they presented with adverse effects. Often, patients failed to comply with such treatment. This opened the door for complementary and alternative medicine. In the present review, we explored the molecular concept of wound healing occurring in different stages with special emphasis to DM. We also highlighted the potential herbal products such as NF3 (Chinese 2-Herb Formula), Zicao, Jing Wan Hong ointment, Aleo vera, mixture of Adiantum capillus-veneris, Commiphora molmol, Aloe vera, and henna, Phenol-rich compound sweet gel, Jinchuang ointment, San-huang-sheng-fu (S) oil, Yi Bu A Jie extract, Astragali Radix (AR) and Rehmanniae Radix (RR), Yiqi Huayu, Tangzu yuyang ointment, Shengji Huayu recipe, Angelica sinensis, Lithospermun erythrorhison, Hippophae rhamnoides L., Curcuma longa and Momordica charantia that could be used effectively to treat DM wounds. Future clinical trials are needed for designing potential drugs which may be effective in treating DM wounds.

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Camel whey protein enhances diabetic wound healing in a streptozotocin-induced diabetic mouse model: the critical role of β-Defensin-1, -2 and -3

Lipids in Health and Disease ◽

10.1186/1476-511x-12-46 ◽

2013 ◽

Vol 12 (1) ◽

Cited By ~ 42

Author(s):

Gamal Badr

Keyword(s):

Wound Healing ◽

Mouse Model ◽

Whey Protein ◽

Critical Role ◽

Diabetic Mouse ◽

Diabetic Wound ◽

Diabetic Wound Healing

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Surgery and Medicinal Plants: A review of important indigenous medicinal plants of Iran for burn wound healing

Plant Science Today ◽

10.14719/pst.2019.6.2.552 ◽

2019 ◽

Vol 6 (2) ◽

pp. 264-269

Author(s):

Masoud Sharifian ◽

Afshin Hasanvand ◽

Gholam Basati ◽

Saber Abbaszadeh

Keyword(s):

Wound Healing ◽

Medicinal Plants ◽

Herbal Remedy ◽

Medical Science ◽

Aloe Vera ◽

Centella Asiatica ◽

Recovery Process ◽

Herbal Remedies ◽

Burn Wound ◽

Burn Wounds

Surgical Science is one of the branches of medical science that deals with surgical and medicinal interventions, which can cure surgical wounds, cuts, burns and so on. The accelerated recovery process has always been a concern for surgeons and physicians. Standard local antibiotic drugs such as silver nitrate, mafenide acetate, sulfadiazine silver and AgNO3 are also used to treat wounds which are associated with some complications. Considering the fact that no effective herbal remedy has been introduced for wound healing, the purpose of this review is to investigate and identify indigenous Iranian herbs used for wound healing after surgery, especially burn wounds. In this systematic review paper, published articles in the period 1952 to 2017 with keywords of surgery, wound healing, burns, herbs, etc. from databases such as SID, MEDLIB, ProQuest, Magiran, Europe PubMed Central and Google Scholar. Abstract and title of all articles were studied and non-relevant articles were deleted and remaining articles were used for review. Based on the results of the study, Malva sylvestris, Camellia sinensis, Aloe vera, Cydonia oblonga, Scrophularia striata, Centella asiatica, Arnebia euchroma, Calendula officinalis and Hypericum perforatum are the most important herbal remedies for burn restoration. The following is an explanation of the most important herbal remedies for native burn wounds in Iran.

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Downregulation of miRNAs during Delayed Wound Healing in Diabetes: Role of Dicer

Molecular Medicine ◽

10.2119/molmed.2014.00186 ◽

2015 ◽

Vol 21 (1) ◽

pp. 847-860 ◽

Cited By ~ 4

Author(s):

Sushant Bhattacharya ◽

Rangoli Aggarwal ◽

Vijay Pal Singh ◽

Srinivasan Ramachandran ◽

Malabika Datta

Keyword(s):

Wound Healing ◽

Delayed Wound Healing

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Beyond hematopoietic targets: the role of erythropoietin in diabetic wound healing

Biomarkers in Medicine ◽

10.2217/bmm.11.30 ◽

2011 ◽

Vol 5 (3) ◽

pp. 365-367

Author(s):

Saher Hamed

Keyword(s):

Wound Healing ◽

Diabetic Wound ◽

Diabetic Wound Healing

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Abnormal Cell Responses and Role of TNF-αin Impaired Diabetic Wound Healing

BioMed Research International ◽

10.1155/2013/754802 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 53

Author(s):

Fanxing Xu ◽

Chenying Zhang ◽

Dana T. Graves

Keyword(s):

Wound Healing ◽

Macrophage Polarization ◽

Diabetic Wound ◽

Major Health Problem ◽

Abnormal Cell ◽

Fibroblast Migration ◽

Cell Responses ◽

Impaired Healing ◽

Diabetic Wound Healing

Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-αalso contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.

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Macrophage polarization in wound healing: role of aloe vera/chitosan nanohydrogel

Drug Delivery and Translational Research ◽

10.1007/s13346-019-00643-0 ◽

2019 ◽

Vol 9 (6) ◽

pp. 1027-1042 ◽

Cited By ~ 2

Author(s):

Fatemeh Ashouri ◽

Fatemeh Beyranvand ◽

Nasim Beigi Boroujeni ◽

Majid Tavafi ◽

Ali Sheikhian ◽

...

Keyword(s):

Wound Healing ◽

Macrophage Polarization ◽

Aloe Vera

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Antioxidant and Wound Healing Property of Gelsolin in 3T3-L1 Cells

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/4045365 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Bhavna Vaid ◽

Bhupinder Singh Chopra ◽

Sachin Raut ◽

Amin Sagar ◽

Maulik D. Badmalia ◽

...

Keyword(s):

Oxidative Stress ◽

Wound Healing ◽

Dependent Manner ◽

Concentration Dependent Manner ◽

Plasma Gelsolin ◽

Total Antioxidant ◽

Effective Role ◽

Healing Property ◽

Injury Recovery

Delineation of factors which affect wound healing would be of immense value to enable on-time or early healing and reduce comorbidities associated with infections or biochemical stress like diabetes. Plasma gelsolin has been identified earlier to significantly enable injury recovery compared to placebo. This study evaluates the role of rhuGSN for its antioxidant and wound healing properties in murine fibroblasts (3T3-L1 cell line). Total antioxidant capacity of rhuGSN increased in a concentration-dependent manner (0.75-200 μg/mL). Cells pretreated with 0.375 and 0.75 μg/mL rhuGSN for 24 h exhibited a significant increase in viability in a MTT assay. Preincubation of cells with rhuGSN for 24 h followed by oxidative stress induced by exposure to H2O2 for 3 h showed cytoprotective effect. rhuGSN at 12.5 and 25 μg/mL concentration showed an enhanced cell migration after 20 h of injury in a scratch wound healing assay. The proinflammatory cytokine IL-6 levels were elevated in the culture supernatant. These results establish an effective role of rhuGSN against oxidative stress induced by H2O2 and in wound healing of 3T3-L1 fibroblast cells.

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