Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia

2017 ◽  
Vol 16 (5) ◽  
pp. 338-348 ◽  
Author(s):  
Jennifer Adair ◽  
Julian Sevilla ◽  
Cristina Heredia ◽  
Pamela Becker ◽  
Hans-Peter Kiem ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Gene Therapy ◽  
Fanconi Anemia ◽  
Lessons Learned ◽  
Trial Experience ◽  
Clinical Trial Experience

scholarly journals Approaches to Establishing Tolerance in Immune Mediated Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Michelle F. Huffaker ◽  
Srinath Sanda ◽  
Sindhu Chandran ◽  
Sharon A. Chung ◽  
E. William St. Clair ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Immune Tolerance ◽  
Lessons Learned ◽  
Iterative Approach ◽  
Mechanistic Studies ◽  
Immune Mediated ◽  
Trial Experience ◽  
Clinical Trial Experience ◽  
New Strategies ◽  
Induction Of Tolerance

The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance.

scholarly journals Correction to: Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience

Drug Safety ◽  
2018 ◽  
Vol 41 (12) ◽  
pp. 1431-1437 ◽  
Author(s):  
John F. Marcinak ◽  
Melvin S. Munsaka ◽  
Paul B. Watkins ◽  
Takashi Ohira ◽  
Neila Smith
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Liver Safety ◽  
Trial Experience ◽  
Global Clinical Trial ◽  
Clinical Trial Experience

scholarly journals Treating cocaine addiction: From preclinical to clinical trial experience with ?-vinyl GABA

Synapse ◽  
2003 ◽  
Vol 50 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Jonathan D. Brodie ◽  
Emilia Figueroa ◽  
Stephen L. Dewey
Keyword(s):  
Clinical Trial ◽  
Cocaine Addiction ◽  
Trial Experience ◽  
Clinical Trial Experience
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