Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

Cancer/testis (CT) antigens exhibit selective expression predominantly in immunoprivileged tissues in non-pathological contexts but are aberrantly expressed in diverse cancers. Due to their expression pattern, they have historically been attractive targets for immunotherapies. A growing number of studies implicate CT antigens in almost all hallmarks of cancer, suggesting that they may act as cancer drivers. CT antigens are expressed in head and neck squamous cell carcinomas. However, their role in the pathogenesis of these cancers remains poorly studied. Given that CT antigens hold intriguing potential as therapeutic targets and as biomarkers for prognosis and that they can provide novel insights into oncogenic mechanisms, their further study in the context of head and squamous cell carcinoma is warranted.

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Abstract 3864: Evaluation of expression of antigens cancer/testis (CTAs) in head and neck squamous cell carcinoma

10.1158/1538-7445.am2011-3864 ◽

2011 ◽

Author(s):

Fernando T. Zamunér ◽

Bruno Takao Real Karia ◽

André Lopes Carvalho ◽

André Luiz Vettore de Oliveira

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Cancer Testis

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Dynamic changes in epithelial to mesenchymal composition and prognostic relevance of circulating cancer cells (CTCs) in head and neck squamous cell carcinoma (HNSCC).

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.6076 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 6076-6076

Author(s):

Elena Mihal Vagia ◽

George Koutsodontis ◽

Areti Strati ◽

Athina Giagini ◽

Spiros Siolos ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Cancer Cells ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Dynamic Changes ◽

Circulating Cancer Cells ◽

Prognostic Relevance

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Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma

International Journal of Cancer ◽

10.1002/ijc.25607 ◽

2010 ◽

Vol 128 (11) ◽

pp. 2625-2634 ◽

Cited By ~ 50

Author(s):

Cyril Cuffel ◽

Jean-Paul Rivals ◽

Yannick Zaugg ◽

Suzanne Salvi ◽

Walter Seelentag ◽

...

Keyword(s):

Gene Expression ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Clinical Significance ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Cancer Testis

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Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

10.20944/preprints202110.0206.v1 ◽

2021 ◽

Author(s):

Sharon Chanshan Wu ◽

Karl Munger

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Research Question ◽

Cancer Testis Antigens ◽

Cancer Drivers ◽

Ct Antigens ◽

Almost All ◽

Cancer Testis

Cancer/testis (CT) antigens exhibit selective expression predominantly in immunoprivileged tissues in non-pathological contexts but are aberrantly expressed in diverse cancers. Because of their expression pattern, they have historically been attractive targets for immunotherapies. The investigation of mechanistic roles of CT antigens in promoting oncogenesis has historically been a prominent research question, and a growing number of studies implicate CT antigens in promoting almost all the hallmarks of cancer. This suggests that CT antigens may act as cancer drivers. CT antigens are expressed in head and neck squamous cell carcinomas, although their role in the pathogenesis, prognostication, and treatment for this family of cancers remains poorly studied. Given that CT antigens hold intriguing potential as therapeutic targets and as biomarkers for prognosis and therapeutic response and that they can provide novel insights into oncogenic mechanisms, their further study in the context of head and squamous cell carcinoma is warranted.

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