The Role of Combined Assessment of Defense Against Oxidative Stress and Inflammation in the Evaluation of Peripheral Arterial Disease

2011 ◽  
Vol 11 (6) ◽  
pp. 453-464 ◽  
Author(s):  
A. Rull ◽  
R. Garcia ◽  
L. Fernandez-Sender ◽  
R. Beltran-Debon ◽  
G. Aragones ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals The Role of Circulating Biomarkers in Peripheral Arterial Disease

2021 ◽  
Vol 22 (7) ◽  
pp. 3601
Author(s):  
Goren Saenz-Pipaon ◽  
Esther Martinez-Aguilar ◽  
Josune Orbe ◽  
Arantxa González Miqueo ◽  
Leopoldo Fernandez-Alonso ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Lower Limb ◽  
Prediction Models ◽  
Arterial Disease ◽  
Cardiac Damage ◽  
Thrombotic Occlusion ◽  
Medical Treatments ◽  
Peripheral Arterial ◽  
Inflammatory Molecules

Peripheral arterial disease (PAD) of the lower extremities is a chronic illness predominantly of atherosclerotic aetiology, associated to traditional cardiovascular (CV) risk factors. It is one of the most prevalent CV conditions worldwide in subjects >65 years, estimated to increase greatly with the aging of the population, becoming a severe socioeconomic problem in the future. The narrowing and thrombotic occlusion of the lower limb arteries impairs the walking function as the disease progresses, increasing the risk of CV events (myocardial infarction and stroke), amputation and death. Despite its poor prognosis, PAD patients are scarcely identified until the disease is advanced, highlighting the need for reliable biomarkers for PAD patient stratification, that might also contribute to define more personalized medical treatments. In this review, we will discuss the usefulness of inflammatory molecules, matrix metalloproteinases (MMPs), and cardiac damage markers, as well as novel components of the liquid biopsy, extracellular vesicles (EVs), and non-coding RNAs for lower limb PAD identification, stratification, and outcome assessment. We will also explore the potential of machine learning methods to build prediction models to refine PAD assessment. In this line, the usefulness of multimarker approaches to evaluate this complex multifactorial disease will be also discussed.

The epidemiology of onychomycosis: possible role of smoking and peripheral arterial disease

2000 ◽  
Vol 14 (6) ◽  
pp. 466-469 ◽  
Author(s):  
Aditya K. Gupta ◽  
Madhulika A. Gupta ◽  
Richard C. Summerbell ◽  
Elizabeth A. Cooper ◽  
Nellie Konnikov ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease

2006 ◽  
Vol 28 (5) ◽  
pp. 608-612 ◽  
Author(s):  
L. Loffredo ◽  
A. Marcoccia ◽  
P. Pignatelli ◽  
P. Andreozzi ◽  
M.C. Borgia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Role of Disease Status and Type D Personality in Outcomes in Patients With Peripheral Arterial Disease

2005 ◽  
Vol 96 (7) ◽  
pp. 996-1001 ◽  
Author(s):  
Annelies E. Aquarius ◽  
Johan Denollet ◽  
Jaap F. Hamming ◽  
Jolanda De Vries
Keyword(s):  
Peripheral Arterial Disease ◽  
Disease Status ◽  
Arterial Disease ◽  
Type D Personality ◽  
Type D ◽  
Peripheral Arterial

The role of intravascular ultrasound in lower limb revascularization in patients with peripheral arterial disease

2017 ◽  
Vol 36 (6) ◽  
Author(s):  
Gregory C. Makris ◽  
Pavlina Chrysafi ◽  
Mark Little ◽  
Rafiuddin Patel ◽  
Mark Bratby ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Intravascular Ultrasound ◽  
Lower Limb ◽  
Arterial Disease ◽  
Peripheral Arterial

Dynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial disease

Vascular ◽  
2020 ◽  
pp. 170853812094724
Author(s):  
Ufuk Turan Kursat Korkmaz ◽  
Ahmet Yuksel ◽  
Ayhan Cetinkaya ◽  
Yusuf Velioglu ◽  
Erhan Renan Ucaroglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factor ◽  
Peripheral Arterial Disease ◽  
Laboratory Data ◽  
Arterial Disease ◽  
Control Group ◽  
Study Group ◽  
Total Thiol ◽  
Peripheral Arterial ◽  
Study Participants

Objective To examine dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in patients with peripheral arterial disease. Methods One hundred patients with lower extremity peripheral arterial disease (a study group) and 100 control subjects were included in this prospective case–control study. Participants’ baseline clinical characteristics and laboratory data including some oxidant/antioxidant status parameters such as albumin, ferroxidase and myeloperoxidase, and thiol/disulphide homeostasis parameters such as native thiol, total thiol and disulphide, as well as native thiol/total thiol, disulphide/native thiol and disulphide/total thiol ratios were all recorded and then compared between the groups. Results Mean albumin and ferroxidase, and median myeloperoxidase levels were found to be significantly higher in patients with the peripheral arterial disease than in control group ( p = 0.045, p = 0.000 and p = 0.000, respectively). Mean native thiol and total thiol, and median disulphide levels were found to be significantly lower in the study group as compared with the control group ( p = 0.000, p = 0.000 and p = 0.037, respectively). According to the results of logistic regression analysis, systolic blood pressure, ferroxidase and myeloperoxidase levels were detected to be the independent predictors of peripheral arterial disease. Conclusion Our report is the first one in the literature investigating dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in peripheral arterial disease. Dynamic thiol/disulphide homeostasis metrics may be used as a valuable risk factor of oxidative stress in patients with the peripheral arterial disease since it is readily available, easily calculated and relatively cheap.

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