scholarly journals Crossing the Blood-Brain Barrier: A Review on Drug Delivery Strategies for Treatment of the Central Nervous System Diseases

2019 ◽  
Vol 16 (8) ◽  
pp. 698-711 ◽  
Author(s):  
Nur Izzati Mansor ◽  
Norshariza Nordin ◽  
Farahidah Mohamed ◽  
King Hwa Ling ◽  
Rozita Rosli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Brain Diseases ◽  
Advantages And Disadvantages ◽  
Blood Brain ◽  
The Central Nervous System ◽  
Delivery Strategies

: Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug delivery systems across the blood-brain barrier are dependent on substrate-specific (i.e. protein transport and transcytosis) and non-specific (i.e. transcellular and paracellular) transport pathways, which are crucial factors in attempts to design efficient drug delivery strategies. This review describes how the blood-brain barrier presents the main challenge in delivering drugs to treat brain diseases and discusses the advantages and disadvantages of ongoing neurotherapeutic delivery strategies in overcoming this limitation. In addition, we discuss the application of colloidal carrier systems, particularly nanoparticles, as potential tools for therapy for the CNS diseases.

scholarly journals Concept of Sharir in Nasya karma

2019 ◽  
Vol 7 (01) ◽  
pp. 05-06
Author(s):  
Navin Banarase
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Nasal Mucosa ◽  
Medical Science ◽  
Brain Barrier ◽  
Blood Brain ◽  
The Central Nervous System ◽  
Delivery Route

Nasya is one of the most important Panchakarma procedures done in Ayurveda. It is mostly done for the Urdhvajatrugata Vikara. The drug has effects on the Central Nervous System also. Hence it is important to elaborate on the concept of Sharir according to Ayurveda and Modern Medical Science to understand this drug delivery route. Nasya gives the drug mainly gets absorbed by capillaries in the nasal mucosa and also crosses the blood-brain barrier (BBB) as mostly the drug is prepared in the form of Sneha. This article will explain the Sharir concept related to the Nasya procedure.

Stimulating brain drug delivery

2020 ◽  
Vol 12 (564) ◽  
pp. eabe8119
Author(s):  
Raag Airan
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Neural Activity ◽  
Brain Barrier ◽  
Brain Drug Delivery ◽  
Blood Brain ◽  
The Central Nervous System

Neural activity affects how the blood-brain barrier regulates influx and efflux of agents between the blood and the central nervous system.

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