Drug Development of Small-Molecule Inhibitors of AD-Relevant Kinases as Novel Perspective Multitargeted Approach

2016 ◽  
Vol 13 (12) ◽  
pp. 1330-1336 ◽  
Author(s):  
V. Tell ◽  
I. Hilbrich ◽  
M. Holzer ◽  
Frank Totzke ◽  
Christoph Schachtele ◽  
...  
Keyword(s):  
Drug Development ◽  
Small Molecule ◽  
Small Molecule Inhibitors

scholarly journals Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

2017 ◽  
Vol 13 (12) ◽  
pp. 2509-2520 ◽  
Author(s):  
Lakshmi Prabhu ◽  
Lan Chen ◽  
Han Wei ◽  
Özlem Demir ◽  
Ahmad Safa ◽  
...  
Keyword(s):  
Drug Development ◽  
Small Molecule ◽  
High Throughput ◽  
Small Molecule Inhibitors ◽  
Disease Treatment ◽  
Protein Arginine Methyltransferases ◽  
Development Pipeline

The proposed workflow of the drug development pipeline with adapted AlphaLISA HTS-based screening to discover inhibitors of epigenetic targets like PRMT5 with possible significance in disease treatment.

Sign in / Sign up

Export Citation Format

Share Document