Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secreted Amyloid Protein Precursor Generated by -Secretase Cleavage

2009 ◽  
Vol 999 (999) ◽  
pp. 1-6
Author(s):  
Rudolph E. Tanzi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Presenilin 1 ◽  
Amyloid Protein ◽  
Familial Alzheimer’S Disease ◽  
Protein Precursor ◽  
Amyloid Protein Precursor ◽  
Disease Mutations ◽  
Familial Alzheimer's Disease

scholarly journals Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

2010 ◽  
Vol 176 (1) ◽  
pp. 353-368 ◽  
Author(s):  
Miguel A. Gama Sosa ◽  
Rita De Gasperi ◽  
Anne B. Rocher ◽  
Athena Ching-Jung Wang ◽  
William G.M. Janssen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Vascular Pathology ◽  
Presenilin 1 ◽  
Familial Alzheimer’S Disease ◽  
Age Related ◽  
Disease Mutations ◽  
Familial Alzheimer's Disease

Familial Alzheimer’s disease mutations in the presenilin 1 gene reduce cell-cell adhesion in transfected fibroblasts

BIOPHYSICS ◽  
2010 ◽  
Vol 55 (5) ◽  
pp. 760-764
Author(s):  
A. L. Schwarzman ◽  
S. V. Sarantseva ◽  
O. L. Runova ◽  
E. I. Talalaeva ◽  
M. P. Vitek
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Adhesion ◽  
Presenilin 1 ◽  
Familial Alzheimer’S Disease ◽  
Disease Mutations ◽  
Familial Alzheimer's Disease ◽  
Cell Cell

scholarly journals Familial Alzheimer's Disease Mutations in Presenilin-1 and Store-Operated Calcium Entry

2011 ◽  
Vol 100 (3) ◽  
pp. 554a
Author(s):  
Maria Ryazantseva ◽  
Lyubov Glushankova ◽  
Ilya Pozdnyakov ◽  
Ilya Bezprozvanny ◽  
Elena Kaznacheyeva
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Entry ◽  
Presenilin 1 ◽  
Familial Alzheimer’S Disease ◽  
Disease Mutations ◽  
Store Operated Calcium Entry ◽  
Familial Alzheimer's Disease

O2-04-06: The role of presenilin 1 familial Alzheimer's disease mutations for gamma-secretase activity and changed structural conformation

2012 ◽  
Vol 8 (4S_Part_7) ◽  
pp. P242-P242
Author(s):  
Patricia Lara Vasquez ◽  
Johanna Wanngren ◽  
Silvia Maioli ◽  
Lars Tjernberg ◽  
Bengt Winblad ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Presenilin 1 ◽  
Gamma Secretase ◽  
Familial Alzheimer’S Disease ◽  
Structural Conformation ◽  
Disease Mutations ◽  
Secretase Activity ◽  
Familial Alzheimer's Disease

Staurosporine-Induced Activation of Caspase-3 Is Potentiated by Presenilin 1 Familial Alzheimer's Disease Mutations in Human Neuroglioma Cells

2002 ◽  
Vol 73 (6) ◽  
pp. 2278-2285 ◽  
Author(s):  
Dora M. Kovacs ◽  
Ronald Mancini ◽  
John Henderson ◽  
Sang J. Na ◽  
Stephen D. Schmidt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Caspase 3 ◽  
Presenilin 1 ◽  
Familial Alzheimer’S Disease ◽  
Disease Mutations ◽  
Familial Alzheimer's Disease

scholarly journals Alzheimer’s Disease Associated Presenilin 1 and 2 Genes Dysregulation in Neonatal Lymphocytes Following Perinatal Asphyxia

2021 ◽  
Vol 22 (10) ◽  
pp. 5140
Author(s):  
Agata Tarkowska ◽  
Wanda Furmaga-Jabłońska ◽  
Jacek Bogucki ◽  
Janusz Kocki ◽  
Ryszard Pluta
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Perinatal Asphyxia ◽  
Hypoxia Inducible Factor ◽  
Presenilin 1 ◽  
Amyloid Protein ◽  
Protein Precursor ◽  
Amyloid Protein Precursor ◽  
Hypoxia Inducible Factor 1 ◽  
Potential Biomarker

Perinatal asphyxia is mainly a brain disease leading to the development of neurodegeneration, in which a number of peripheral lesions have been identified; however, little is known about the expression of key genes involved in amyloid production by peripheral cells, such as lymphocytes, during the development of hypoxic-ischemic encephalopathy. We analyzed the gene expression of the amyloid protein precursor, β-secretase, presenilin 1 and 2 and hypoxia-inducible factor 1-α by RT-PCR in the lymphocytes of post-asphyxia and control neonates. In all examined periods after asphyxia, decreased expression of the genes of the amyloid protein precursor, β-secretase and hypoxia-inducible factor 1-α was noted in lymphocytes. Conversely, expression of presenilin 1 and 2 genes decreased on days 1–7 and 8–14 but increased after survival for more than 15 days. We believe that the expression of presenilin genes in lymphocytes could be a potential biomarker to determine the severity of the post-asphyxia neurodegeneration or to identify the underlying factors for brain neurodegeneration and get information about the time they occurred. This appears to be the first worldwide data on the role of the presenilin 1 and 2 genes associated with Alzheimer’s disease in the dysregulation of neonatal lymphocytes after perinatal asphyxia.

Sign in / Sign up

Export Citation Format

Share Document