Bioactive Small Molecules: Promising Novel Therapies in Cardiovascular Diseases – PART II

2019 ◽  
Vol 19 (21) ◽  
pp. 1877-1877
Author(s):  
Yu Yu
Keyword(s):  
Cardiovascular Diseases ◽  
Small Molecules ◽  
Novel Therapies

scholarly journals microRNAs in the onset and development of cardiovascular disease

2013 ◽  
Vol 126 (3) ◽  
pp. 183-194 ◽  
Author(s):  
Kasey C. Vickers ◽  
Kerry-Anne Rye ◽  
Fatiha Tabet
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Present Review ◽  
Novel Therapies ◽  
Regulatory Processes ◽  
Gene Regulatory

Physiological and pathological roles for small non-encoding miRNAs (microRNAs) in the cardiovascular system have recently emerged and are now widely studied. The discovery of widespread functions of miRNAs has increased the complexity of gene-regulatory processes and networks in both the cardiovascular system and cardiovascular diseases. Indeed, it has recently been shown that miRNAs are implicated in the regulation of many of the steps leading to the development of cardiovascular disease. These findings represent novel aspects in miRNA biology and, therefore, our understanding of the role of these miRNAs during the pathogenesis of cardiovascular disease is critical for the development of novel therapies and diagnostic interventions. The present review will focus on understanding how miRNAs are involved in the onset and development of cardiovascular diseases.

scholarly journals Spotlight on small molecules in cardiovascular diseases

2018 ◽  
Vol 175 (8) ◽  
pp. 1111-1113
Author(s):  
Xin Wang ◽  
Yu Huang ◽  
Yong Ji
Keyword(s):  
Cardiovascular Diseases ◽  
Small Molecules

Small Molecules with Big Impacts on Cardiovascular Diseases

2020 ◽  
Vol 58 (3) ◽  
pp. 359-383 ◽  
Author(s):  
Fatemeh Mirzadeh Azad ◽  
Maedeh Arabian ◽  
Majid Maleki ◽  
Mahshid Malakootian
Keyword(s):  
Cardiovascular Diseases ◽  
Small Molecules

scholarly journals Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases

2020 ◽  
Vol 21 (2) ◽  
pp. 509 ◽  
Author(s):  
Alessia Mongelli ◽  
Sandra Atlante ◽  
Tiziana Bachetti ◽  
Fabio Martelli ◽  
Antonella Farsetti ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Small Molecules ◽  
Rna Structure ◽  
Therapeutic Interventions ◽  
Epigenetic Changes ◽  
Epigenetic Landscape ◽  
Rna Modifications ◽  
Rna Regulation ◽  
Structure Regulation

RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes in RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.

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