Oral Administration of L-Serine Increases L- and D-Serine Levels in the Plasma and Brain of Fasted Rats

2012 ◽  
Vol 9 (7) ◽  
pp. 663-667 ◽  
Author(s):  
Shozo Tomonaga ◽  
Izumi Yamasaki ◽  
Mao Nagasawa ◽  
Yumi Ogino ◽  
Nobuo Uotsu ◽  
...  
Keyword(s):  
Oral Administration ◽  
Fasted Rats

scholarly journals Effect of oral glutathione on hepatic glutathione levels in rats and mice

1989 ◽  
Vol 62 (3) ◽  
pp. 683-691 ◽  
Author(s):  
Jose Viña ◽  
Carmen Perez ◽  
Tadayasu Furukawa ◽  
Manuel Palacin ◽  
Juan R. Viña
Keyword(s):  
Amino Acids ◽  
Oral Administration ◽  
Blood Plasma ◽  
Oral Intake ◽  
Diethyl Maleate ◽  
Hepatic Glutathione ◽  
Buthionine Sulphoximine ◽  
High Doses ◽  
Rats And Mice ◽  
Fasted Rats

Administration of oral glutathione (GSH) increases hepatic GSH levels in fasted rats, in mice treated with GSH depletors such as diethyl maleate and in mice treated with high doses of paracetamol. An increase in hepatic GSH levels after administration of oral GSH does not occur in animals treated with buthionine sulphoximine, an inhibitor of GSH synthesis. Administration of oral GSH leads to an increase in the concentration of l-cysteine, a precursor of GSH, in portal blood plasma. Oral administration of l-methionine produced a significant decrease of hepatic ATP in fasted rats, but not in fed rats. Administration of N−acetylcysteine or GSH did not affect the hepatic ATP levels. The results show that the oral intake of GSH is a safe and efficient form of administration of its constituent amino acids in cases when GSH synthesis is required to replete hepatic GSH levels.

Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress

2015 ◽  
Vol 26 (5) ◽  
Author(s):  
Deepa Thomas ◽  
Sindhu Govindhan ◽  
Edathiruthykottuckkal Chandran Baiju ◽  
Ganesan Padmavathi ◽  
Ajaikumar B. Kunnumakkara ◽  
...  
Keyword(s):  
Oral Administration ◽  
Mucosal Damage ◽  
Cyperus Rotundus ◽  
Gastric Mucosal Damage ◽  
Ulcer Index ◽  
Drug Induced ◽  
Single Oral Administration ◽  
Tissue Lipid Peroxidation ◽  
Fasted Rats ◽  
Different Doses

AbstractSince centuries,Seventy percent methanolic extract of the plant was prepared and fed to 36-h fasted rats. Ulcer was induced in these rats by single oral administration of aspirin (400 mg/kg) 1 h after the administration of the plant extract. After 4 h, the rats were sacrificed, ulcer index was calculated, and antioxidant activity of the extract in gastric mucosa was evaluated by determining the levels of superoxide dismutase, glutathione, glutathione peroxidase, and tissue lipid peroxidation.Oral administration of different doses ofOur results showed that

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