Relapsing Remitting Multiple Sclerosis and its Relationship with the Immune System and Oxidative Stress

2018 ◽  
Vol 14 (1) ◽  
pp. 15-23
Author(s):  
Ada Paloma Soto-Brambila ◽  
Genaro Gabriel Ortiz ◽  
Paloma Rivero-Moragrega ◽  
Ana Laura Briones-Torres ◽  
Luis Javier Gonzalez-Ortiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Immune System ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
And Oxidative Stress

Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis

2018 ◽  
Vol 49 (6) ◽  
pp. 391-398 ◽  
Author(s):  
Angélica L. Sánchez-López ◽  
Genaro Gabriel Ortiz ◽  
Fermín P. Pacheco-Moises ◽  
Mario A. Mireles-Ramírez ◽  
Oscar K. Bitzer-Quintero ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Inflammatory Cytokines ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines

scholarly journals The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Bożena Adamczyk ◽  
Sławomir Wawrzyniak ◽  
Sławomir Kasperczyk ◽  
Monika Adamczyk-Sowa
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
De Novo ◽  
Immunomodulatory Therapy ◽  
Lipid Hydroperoxides ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
And Gender ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

Objectives. The assessment of oxidative stress (OS) in serum relapsing-remitting multiple sclerosis patients treated with II-line immunomodulatory therapy (fingolimod, natalizumab) compared to newly diagnosed patients (de novo group) treated with interferon (IFN) beta and controls. The relationship between OS parameters and gender, age, disease duration, Expanded Disability Status Scale, annualized relapse rate, MRI lesions in patients treated with II-line.Materials and Methods. One hundred and twenty-one patients with RRMS were enrolled in the study. Patients were divided into groups: de novo group, IFN, fingolimod (FG), natalizumab (NT), and controls. Lipid hydroperoxides (LHP), malondialdehyde (MDA), lipofuscin (LPS), and total oxidative status (TOS) were determined.Results. LHP, MDA, and TOS were lower in NT and FG groups compared to the de novo group. Levels of OS were different between NT and FG patients and the IFN group. Women treated with FG and NT had lower MDA, LPH, and TOS than women who were not treated while in men only LPH was lowered. Positive correlations were found between MDA, LHP, TOS, and ARR in the NT group.Conclusion. The II-line immunomodulatory treatment decreased OS particularly among women. No difference in OS levels was observed between II-line therapy and IFN beta.

Peripheral oxidative stress in relapsing–remitting multiple sclerosis

2012 ◽  
Vol 45 (6) ◽  
pp. 440-444 ◽  
Author(s):  
Inmaculada Tasset ◽  
Eduardo Agüera ◽  
Fernando Sánchez-López ◽  
Montserrat Feijóo ◽  
Ana I. Giraldo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals Oxidative Stress is Increased in Serum from Mexican Patients with Relapsing-Remitting Multiple Sclerosis

2009 ◽  
Vol 26 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Genaro Gabriel Ortiz ◽  
Miguel Ángel Macías-Islas ◽  
Fermín P. Pacheco-Moisés ◽  
José A. Cruz-Ramos ◽  
Silvia Sustersik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Healthy Controls ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Mcdonald Criteria ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Nitric Oxide Metabolites ◽  
Relapsing Remitting Multiple Sclerosis

Objective: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis.Methods: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification.Results: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.

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