Withdrawal Notice: The Recent Advancement in the Field of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) for Aiming Breast Cancer

Purpose: Sentinel node is routinely localized with the intraoperative use of a radioactive tracer, involving challenging logistics. Super paramagnetic iron oxide nanoparticle is a non-radioactive tracer with comparable performance that could allow for preoperative localization, would simplify the procedure, and possibly be of value in axillary mapping before neoadjuvant treatment. The current trial aimed to determine the a priori hypothesis that the injection of super paramagnetic iron oxide nanoparticles in the preoperative period for the localization of the sentinel node is feasible. Methods: This is a prospective feasibility trial, conducted from 9 September 2014 to 22 October 2014 at Uppsala University Hospital. In all, 12 consecutive patients with primary breast cancer planned for resection of the primary and sentinel node biopsy were recruited. Super paramagnetic iron oxide nanoparticles were injected in the preoperative visit in the outpatient clinic. The radioactive tracer (99mTc) and the blue dye were injected perioperatively in standard fashion. A volunteer was injected with super paramagnetic iron oxide nanoparticles to follow the decline in the magnetic signal in the sentinel node over time. The primary outcome was successful sentinel node detection. Results: Super paramagnetic iron oxide nanoparticles’ detection after preoperative injection (3–15 days) was successful in all cases (100%). In the volunteer, axillary signal was presented for 4 weeks. No adverse effects were noted. Conclusion and relevance: Preoperative super paramagnetic iron oxide nanoparticles’ injection is feasible and leads to successful detection of the sentinel node. That may lead to simplified logistics as well as the identification, sampling, and marking of the sentinel node in patients planned for neoadjuvant treatment.

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43. Super paramagnetic iron oxide nanoparticles for sentinel node detection in patients with breast cancer: Experience from seven centres in Sweden and Denmark

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2016.06.049 ◽

2016 ◽

Vol 42 (9) ◽

pp. S83 ◽

Cited By ~ 1

Author(s):

A. Karakatsanis ◽

P.M. Christiansen ◽

L. Fischer ◽

C. Hedin ◽

L. Pistioli ◽

...

Keyword(s):

Breast Cancer ◽

Iron Oxide ◽

Sentinel Node ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Sentinel Node Detection ◽

Super Paramagnetic Iron Oxide ◽

Cancer Experience

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Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2015.10834 ◽

2015 ◽

Vol 15 (9) ◽

pp. 6413-6422 ◽

Cited By ~ 19

Author(s):

Dinesh Vyas ◽

Nicolas Lopez-Hisijos ◽

Sulakshana Gandhi ◽

M. El-Dakdouki ◽

Marc D. Basson ◽

...

Keyword(s):

Breast Cancer ◽

Iron Oxide ◽

Cancer Cells ◽

Iron Oxide Nanoparticles ◽

Breast Cancer Cells ◽

Oxide Nanoparticles ◽

Super Paramagnetic Iron Oxide ◽

Nf Kappab

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Withdrawal Notice: Lead Optimization from Natural Ligands by In-Silico Approach for Discovering Potential Monoamine Oxidasesinhibitors (MAOIs)

Current Drug Metabolism ◽

10.2174/1389200221666200502014314 ◽

2020 ◽

Vol 21 ◽

Author(s):

Priyanka Dhiman ◽

Neelam Malik ◽

Anurag Khatkar

Keyword(s):

Drug Metabolism ◽

In Silico ◽

Editorial Policy ◽

Lead Optimization ◽

Editorial Policies ◽

Current Drug ◽

Natural Ligands ◽

Copyright Permission ◽

Legal Right

The article has been withdrawn at the request of the authors and editor of the journal Current Drug Metabolism. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

Current Radiopharmaceuticals ◽

10.2174/1874471013666200430094113 ◽

2020 ◽

Vol 13 ◽

Author(s):

Selin Yılmaz ◽

Çiğdem İçhedef ◽

Kadriye Buşra Karatay ◽

Serap Teksöz

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Iron Oxide ◽

Cancer Cells ◽

Iron Oxide Nanoparticles ◽

Breast Cancer Cells ◽

Cancer Drug ◽

Oxide Nanoparticles ◽

Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

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