Severity Evaluation of Regional Cerebrovascular Reactivity in Acute Stroke Patients using SPECT

2022 ◽  
Vol 18 ◽  
Author(s):  
Chang-Ki Kang ◽  
Min-Gyu Song ◽  
Jiwon Yang ◽  
Haejun Lee ◽  
Yeong-Bae Lee
Keyword(s):  
Acute Stroke ◽  
Single Photon ◽  
Photon Emission ◽  
Cerebrovascular Reactivity ◽  
Emission Computed Tomography ◽  
Important Indicator ◽  
The Mean ◽  
The Difference ◽  
Severity Of The Disease ◽  
Photon Emission Computed Tomography

Background: Cerebrovascular reactivity (CVR), as measured using perfusion single photon emission computed tomography (SPECT), is an important indicator for the treatment and prognosis of cerebrovascular disease, but there are few studies of acute stroke or small vascular disease using SPECT. Objective: This study was to evaluate the regional severity with quantitatively determined CVR in patients with acute stroke. Method: Fifty-eight patients who took brain SPECT images were selected to localize quantitative CVR values. The severity of the disease (Grade 1 to 4) was determined through image-based clinical assessment in the absence and presence of a CVR map and their results were compared. Results: In 1st diagnosis without the map, the mean CVR values of Grades 2 and 3 were -6.07% and -9.12%, respectively (P=0.034), while they were -4.78% and -12.34% in 2nd diagnosis with the map, respectively (P<0.001), suggesting that the CVR difference with the map was much more pronounced than without the map. Furthermore, in the ROC analysis, the diagnostic sensitivity between Grades 2 and 3 in 2nd diagnosis (AUC=0.899, P<0.001) was substantially greater than 1st diagnosis (AUC=0.646, P=0.048). Conclusion: This study demonstrated the quantitative CVR maps could reinforce the clinical evaluation of cerebral severity by showing that they can provide statistically significant results between severity and CVR. Furthermore, this study was the first to evaluate the effectiveness of quantitative CVR by examining the difference in the presence or absence of CVR in patients with acute stroke.

scholarly journals Estimation of Cerebral Perfusion Reserve by Blood Oxygenation Level—Dependent Imaging: Comparison with Single-Photon Emission Computed Tomography

2003 ◽  
Vol 23 (1) ◽  
pp. 121-135 ◽  
Author(s):  
Akihiko Shiino ◽  
Yasuo Morita ◽  
Atsushi Tsuji ◽  
Kengo Maeda ◽  
Ryuta Ito ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Blood Oxygenation ◽  
Reserve Capacity ◽  
Emission Computed Tomography ◽  
Cerebrovascular Reserve ◽  
Oxygenation Level ◽  
The Mean ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Measurement of cerebrovascular reserve capacity predicts the risk of ischemic insult in patients with major vessel occlusion. Blood oxygenation level-dependent (BOLD) imaging has the potential to estimate reserve capacity of the cerebral circulation noninvasively based on changes in the signal that reflect differences in the magnetic susceptibility of intravascular oxyhemoglobin and deoxyhemoglobin. The authors examined the feasibility of using the BOLD technique to assess cerebrovascular reserve capacity in patients with cerebrovascular occlusive disease by comparing results with an established method of measuring CBF. Ten patients with severe or complete occlusion of the internal carotid artery were compared with 17 healthy subjects to evaluate regional differences and identify variables that indicate a change in the BOLD signal. Dilation of cerebral vessels was induced by breath holding, and the R2* change was examined with gradient-echo, echo-planar imaging. Before measuring the regional change in the BOLD signal, actual timing of “activated” and “rest” periods was corrected by shifting the phase of a sine-wave template to obtain the largest correlation coefficient. Percent signal change was calculated on a pixel-by-pixel basis and was compared with CBF measured by single-photon emission computed tomography (SPECT) before and after acetazolamide challenge. The degree of impairment and the distribution of impaired areas detected by the BOLD study correlated with the results of SPECT. Overall sensitivity and specificity of the BOLD technique by visual inspection were 100% and 98.4%, respectively. A negative response (decreased CBF) frequently was observed in areas of exhausted reserve capacity, suggesting that a “steal” phenomenon exists. The percent change and the ΔCBF were well correlated ( P < 0.01). The mean percent change in most areas of impaired reserve capacity was more than 2 SD below the mean values in healthy subjects. The present method of semiquantitative BOLD analysis can be used to create a map of the cerebral hemodynamic state. Furthermore, the development of reliable, generally accessible techniques for evaluating cerebral hemodynamics opens the door for clinical studies to monitor and treat patients with compromised reserve. This study is an attempt to develop such analysis.

scholarly journals Correlations Between Single-Photon Emission Computed Tomography Parameters of Salivary Glands and Dry Eye Tests in Patients With Sjögren's Syndrome

2022 ◽  
Vol 8 ◽  
Author(s):  
Xiaoyu Huang ◽  
Lingjuan Xu ◽  
Wei Wang ◽  
Weikun Hu ◽  
Xinyu Li ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Dry Eye ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Parotid Glands ◽  
Submandibular Glands ◽  
The Mean ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

ObjectiveTo evaluate the correlations between Single-Photon Emission Computed Tomography (SPECT) parameters of salivary glands and dry eye parameters in patients with Sjögren's syndrome (SS).MethodsA total of 28 patients with SS participated in this prospective study. Dry eye assessments include tear film break-up time (TBUT), corneal fluorescein staining scoring (CFS), Schirmer's I test (SIT) examination and SPECT of salivary gland. The following quantitative parameters were derived from SPECT imaging for salivary glands: Uptake index (UI), the time needed to achieve the minimum counts after Vit C stimulation (Ts), and excretion fraction (EF). The relation between the aforementioned parameters and TBUT, CFS and SIT were analyzed with SPSS 22.0 software.ResultsAll the 28 eyes of the 28 subjects were examined. The mean SIT was 6.04 ± 4.64 mm/5 min (0–18 mm/5 min); the mean CFS was 3.07 ± 2.65 (0–10) and the mean BUT was 2.11 ± 1.97 s (0–9 s). The mean EF value was 0.52 ± 0.12 (0.26–0.75) in parotid glands and 0.45 ± 0.10 (0.30–0.67) in submandibular glands, respectively. The mean UI value was 9.33 ± 1.68 (6.03–13.20) in parotid glands and 9.92 ± 1.48 (7.08–12.60) in submandibular glands, respectively. The mean Ts (min) was 5.32 ± 3.01 (2.00–12.00) in parotid glands and 11.09 ± 7.40 (2.00- 29.00 min) in submandibular glands, respectively. It was found that EF positively correlates with SIT in patients with SS (r = 0.499 and 0.426 in parotid glands and submandibular glands, with P &lt; 0.05), while no significant correlation was found between the UI, Ts and CFS, TBUT (P &gt; 0.05).ConclusionsThe EF was positively correlated with SIT in patients with SS, it could reflex the dysfunction of salivary glands in SS patients. So, EF may be a valuable parameter for the diagnosis of SS patients with lacrimal gland secretion dysfunction.

Comparison between planar and single-photon emission computed tomography images for radiation intensity quantification in iodine-131 scintigraphy

2021 ◽  
Author(s):  
Yusuke Iizuka ◽  
Tomohiro Katagiri ◽  
Minoru Inoue ◽  
Kiyonao Nakamura ◽  
Takashi Mizowaki
Keyword(s):  
Radiation Dose ◽  
Single Photon ◽  
Photon Emission ◽  
Correlation Coefficients ◽  
Emission Computed Tomography ◽  
Planar Images ◽  
Iodine 131 ◽  
The Mean ◽  
Photon Emission Computed Tomography ◽  
Spect Images

Abstract This study aimed to evaluate the feasibility of quantifying iodine-131 (131I) accumulation in scintigraphy images and compare planar and single-photon emission computed tomography (SPECT) images to estimate 131I radioactivity in patients receiving radioactive iodine therapy for thyroid cancer. We evaluated 72 sets of planar and SPECT images acquired between February 2017 and December 2018. Simultaneously, we placed a reference 131I capsule next to the patient during image acquisition. We evaluated the correlation between the intensity of the capsule in the images and the capsule dose and estimated the radiation dose at the thyroid bed. The mean capsule dose was 2.14 MBq (range, 0.63–4.31 MBq). The correlation coefficients (p-value) between capsule dose and maximum and mean intensities in both planar and SPECT images were 0.93 (p < 0.01), 0.96 (p < 0.01), 0.60 (p < 0.01), and 0.47 (p < 0.01), respectively. The mean intensities of planar images show the highest correlation coefficients. Based on a regression equation, the average radiation dose in the thyroid bed was 5.9 MBq. In conclusion, planar images reflected the radiation dose more accurately than SPECT images. The regression equation allows to determine the dose in other regions, such as the thyroid bed or sites of distant metastasis.

Migraine Aura Lasting 1–24 h in Children: A Sequence of EEG Slow-Wave Abnormalities Vs. Vascular Events

Cephalalgia ◽  
2007 ◽  
Vol 27 (9) ◽  
pp. 1043-1049 ◽  
Author(s):  
D Parain ◽  
A Hitzel ◽  
E Guegan-Massardier ◽  
A Lebas ◽  
C Blondeau ◽  
...  
Keyword(s):  
Slow Wave ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Migraine Aura ◽  
Single Photon Emission ◽  
Vascular Events ◽  
The Mean ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

The aim of this study was to describe the abnormalities associated with migraine aura lasting 1–24 h in children as shown by EEG, trancranial Doppler (TCD) and single photon emission computed tomography (SPECT). In this retrospective study, 11 patients each underwent EEG, TCD and brain SPECT on the day of admission and the day thereafter. On the day of admission, the migrainous hemisphere of all patients showed that the mean velocities were decreased in the middle cerebral artery by TCD, slow-wave abnormalities were recorded after several hours of aura by EEG and the SPECT showed hypoperfusion. On the day after, in the same hemisphere, slow waves were recorded only in the occipital area by EEG, and SPECT showed slight hyperperfusion. In these patients, there was a clear sequence of EEG, TCD and SPECT abnormalities.

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