Recent Clinical Trials of mTOR-Targeted Cancer Therapies

2011 ◽  
Vol 6 (1) ◽  
pp. 24-35 ◽  
Author(s):  
Aruni S. Arachchige Don ◽  
X. F. Steven Zheng
Keyword(s):  
Clinical Trials ◽  
Cancer Therapies ◽  
Targeted Cancer Therapies

scholarly journals Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 723
Author(s):  
Valerie J. Carpenter ◽  
Tareq Saleh ◽  
David A. Gewirtz
Keyword(s):  
Cancer Therapy ◽  
Tumor Cell ◽  
Cancer Therapies ◽  
Cell Models ◽  
Future Directions ◽  
Targeted Cancer Therapies

Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies. Consequently, senolytic use has been proposed as a potential adjuvant approach to improve the response to senescence-inducing conventional and targeted cancer therapies. Despite the unequivocal promise of senolytics, issues of universality, selectivity, resistance, and toxicity remain to be further clarified. In this review, we attempt to summarize and analyze the current preclinical literature involving the use of senolytics in senescent tumor cell models, and to propose tenable solutions and future directions to improve the understanding and use of this novel class of drugs.

scholarly journals The reimbursement of targeted cancer therapies in Bulgaria: is it evidence-based?

2015 ◽  
Vol 25 (suppl_3) ◽  
Author(s):  
T Vekov ◽  
R Koleva-Kolarova ◽  
S Aleksandrova-Yankulovska ◽  
N Veleva
Keyword(s):  
Evidence Based ◽  
Cancer Therapies ◽  
Targeted Cancer Therapies

scholarly journals Molecular and Clinical Approach to Intra-abdominal Adverse Effects of Targeted Cancer Therapies

Radiographics ◽  
2017 ◽  
Vol 37 (5) ◽  
pp. 1461-1482 ◽  
Author(s):  
Stephanie T. Chang ◽  
Christine O. Menias ◽  
Meghan G. Lubner ◽  
Vincent M. Mellnick ◽  
Amy K. Hara ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Clinical Approach ◽  
Cancer Therapies ◽  
Targeted Cancer Therapies
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