Regulative Role of Atomic Auto Correlated Electronegativities and Polarizabilities in β2 Potency of Ultralong Acting Agonists Identified in QSAR Studies

2015 ◽  
Vol 10 (5) ◽  
pp. 503-508 ◽  
Author(s):  
Srinivas Bandaru ◽  
Vinod Cingeetham ◽  
Uday Raj Akare ◽  
Deeksha Yadav ◽  
Nihit Aggarwal ◽  
...  
Keyword(s):  
2009 ◽  
Vol 28 (4) ◽  
pp. 341-348 ◽  
Author(s):  
Jana Malá ◽  
Pavlína Máchová ◽  
Helena Cvrčková ◽  
Michal Karady ◽  
Ondřej Novák ◽  
...  

Author(s):  
Khac-Minh Thai ◽  
Trong-Nhat Do ◽  
Thuy-Viet-Phuong Nguyen ◽  
Duc-Khanh-Tho. Nguyen ◽  
Thanh-Dao Tran

Antimicrobial drug resistance occurs when bacteria undergo certain modifications to eliminate the effectiveness of drugs, chemicals, or other agents designed to cure infections. To date, the burden of resistance has remained one of the major clinical concerns as it renders prolonged and complicated treatments, thereby increasing the medical costs with lengthier hospital stays. Of complex causes for bacterial resistance, there has been increasing evidence that proved the significant role of efflux pumps in antibiotic resistance. Coadministration of Efflux Pump Inhibitors (EPIs) with antibiotics has been considered one of the promising ways not only to improve the efficacy but also to extend the clinical utility of existing antibiotics. This chapter begins with outlining current knowledge about bacterial efflux pumps and drug designs applied in identification of their modulating compounds. Following, the chapter addresses and provides a discussion on Quantitative Structure-Activity Relationship (QSAR) analyses in search of novel and potent efflux pump inhibitors.


2009 ◽  
Vol 96 (4) ◽  
pp. 1661-1670 ◽  
Author(s):  
Sarit Anava ◽  
Alon Greenbaum ◽  
Eshel Ben Jacob ◽  
Yael Hanein ◽  
Amir Ayali

2000 ◽  
Vol 10 (3) ◽  
pp. 351-366 ◽  
Author(s):  
Harriette Marshall ◽  
Anne Woollett
Keyword(s):  

2005 ◽  
Vol 11 (6) ◽  
pp. 695-708 ◽  
Author(s):  
Gil Regev ◽  
Ian F. Alexander ◽  
Alain Wegmann

1986 ◽  
Vol 12 (2) ◽  
Author(s):  
T. H. Veldsman

Fundamental concepts of Industrial Psychology. The aim of the article is to identify the fundamental (or key) concepts of Industrial Psychology and to determine their interrelationship. In the first instance the role of fundamental concepts in the practice of science is indicated. Hereafter the following fundamental concepts are identified for Industrial Psychology, viz. "science", "man", "work" and "psychic". The fundamental concept "science" plays a initiating and regulative role with respect to the other fundamental concepts. The fundamental concepts "work" and "man" together indicate the field of study and the fundamental concept "psychic" the focus point of Industrial Psychology as a discipline. Opsomming Die grondbegrippe van die Bedryfsielkunde. Die doel van die artikel is om die grondbegrippe van die Bedryfsielkunde te identifiseer en hul onderlinge verhouding te bepaal. Die rol van grondbegrippe in wetenskapsbeoefening word ter aanvang eers bespreek. Hiema word die volgende grondbegrippe vir die Bedryfsielkunde geidentifiseer, te wete "wetenskap", "mens", "arbeid" en "psigiese". Die grondbegrip "wetenskap" tree inisierend en regulatief ten opsigte van die ander grondbegrippe op. Die grondbegrippe "arbeid" en "mens" vorm gesamentlik die studieveld en die grondbegrip "psigiese" die kenobjek van die Bedryfsielkunde.


Sign in / Sign up

Export Citation Format

Share Document