Neuropilin and Neuropilin Associated Molecules as New Molecular Targets in Pancreatic Adenocarcinoma

2011 ◽  
Vol 11 (5) ◽  
pp. 442-447 ◽  
Author(s):  
Michael H. Muders
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Molecular Targets ◽  
New Molecular Targets

scholarly journals Helping Eve Overcome ADAM: G-Quadruplexes in the ADAM-15 Promoter as New Molecular Targets for Breast Cancer Therapeutics

Molecules ◽  
2013 ◽  
Vol 18 (12) ◽  
pp. 15019-15034 ◽  
Author(s):  
Robert Brown ◽  
Vanessa Gaerig ◽  
Taesha Simmons ◽  
Tracy Brooks
Keyword(s):  
Breast Cancer ◽  
Molecular Targets ◽  
Cancer Therapeutics ◽  
New Molecular Targets

scholarly journals Plasmodium falciparum: new molecular targets with potential for antimalarial drug development

2009 ◽  
Vol 7 (9) ◽  
pp. 1087-1098 ◽  
Author(s):  
Donald L Gardiner ◽  
Tina S Skinner-Adams ◽  
Christopher L Brown ◽  
Katherine T Andrews ◽  
Colin M Stack ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Drug Development ◽  
Antimalarial Drug ◽  
Molecular Targets ◽  
New Molecular Targets

Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma

2019 ◽  
Vol 235 (4) ◽  
pp. 3776-3789 ◽  
Author(s):  
Guangzhen Wu ◽  
Zhiwei Zhang ◽  
Qizhen Tang ◽  
Lei Liu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Molecular Targets ◽  
Cell Renal Cell Carcinoma ◽  
New Molecular Targets

New molecular targets in meningiomas

2018 ◽  
Vol 31 (6) ◽  
pp. 740-746 ◽  
Author(s):  
Vyshak Alva Venur ◽  
Sandro Santagata ◽  
Eva Galanis ◽  
Priscilla K. Brastianos
Keyword(s):  
Molecular Targets ◽  
New Molecular Targets

scholarly journals Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Valentin Trofimov ◽  
Sébastien Kicka ◽  
Sabrina Mucaria ◽  
Nabil Hanna ◽  
Fernando Ramon-Olayo ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Molecular Targets ◽  
New Molecular Targets

Abstract B202: Identification of new molecular targets in glioblastoma.

2011 ◽  
Author(s):  
Biljana Stangeland ◽  
Mrinal Joel ◽  
Awais Mughal ◽  
Zanina Grieg ◽  
Ingunn Ramsnes ◽  
...  
Keyword(s):  
Molecular Targets ◽  
New Molecular Targets

scholarly journals Beyond KRAS: Practical Molecular Targets in Pancreatic Adenocarcinoma

2019 ◽  
Vol 12 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Albert Grinshpun ◽  
Yonaton Zarbiv ◽  
Jason Roszik ◽  
Vivek Subbiah ◽  
Ayala Hubert
Keyword(s):  
Clinical Trials ◽  
Targeted Therapy ◽  
Pancreatic Adenocarcinoma ◽  
Targeted Therapies ◽  
Kras Mutation ◽  
Molecular Targets ◽  
Driver Mutations ◽  
Proof Of Concept ◽  
Genomic Analyses ◽  
Variable Success

Pancreatic adenocarcinoma (PDAC) has a grim prognosis. Molecular and genomic analyses revealed that the striking majority of these tumors are driven by KRAS mutation, currently not amenable to targeted therapy. However, other driver mutations were found in a small fraction of patients. Herein we report of 3 cases of patients with metastatic PDAC and wildtype KRAS, found to harbor BRAF or RET pathogenic alterations. The patients were treated with targeted therapies with variable success. In our opinion, those proof-of-concept cases argue in favor of additional research and clinical trials’ effort in this small but significant PDAC population with uncommon driver mutations.

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