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Breast cancer is the most common type of malignancy among ladies (around 30% of newly diagnosed patients
every year). To date, various modern treatment modalities for breast cancer, such as radiotherapy, surgical method,
hormonal therapy, and chemotherapeutic drug utilisation, are available. However, adverse drug reactions, therapeutic
resistance, metastasis, or cancer reoccurrence chances remain the primary causes of mortality for breast cancer patients.
To overcome all the potential drawbacks, we need to investigate novel techniques and strategies previously not considered
and treat breast cancer effectively with safety and efficacy. For centuries, we utilise phytochemicals to treat various
diseases because of their safety, low-cost & least or no side effects. Recently, naturally produced phytochemicals
gain immense attention as potential breast cancer therapeutics because of their ideal characteristics; for instance, they
operate via modulating molecular pathways associated with cancer growth and progression. The primary mechanism
involves inhibition of cell proliferation, angiogenesis, migration, invasion, increasing anti-oxidant status, initiation of the
arrest of the cell cycle, and apoptosis. Remedial viability gets effectively enhanced when phytochemicals work as
adjuvants with chemotherapeutic drugs. This comprehensive review revolves around the latest chemopreventive,
chemotherapeutic, and chemoprotective treatments with their molecular mechanisms to treat breast cancer by utilising
phytochemicals such as vinca alkaloids, resveratrol, curcumin, paclitaxel, silibinin, quercetin, genistein and
epigallocatechin gallate. The authors wish to extend the field of phytochemical study for its scientific validity and its
druggability.
Helping Eve Overcome ADAM: G-Quadruplexes in the ADAM-15 Promoter as New Molecular Targets for Breast Cancer Therapeutics
