The Echinocandins: Total and Semi-Synthetic Approaches in Antifungal Drug Discovery

2007 ◽  
Vol 6 (3) ◽  
pp. 201-212 ◽  
Author(s):  
Adam R. Renslo
Keyword(s):  
Drug Discovery ◽  
Antifungal Drug ◽  
Synthetic Approaches

New Lead Structures in Antifungal Drug Discovery

2011 ◽  
Vol 18 (5) ◽  
pp. 733-766 ◽  
Author(s):  
Chunquan Sheng ◽  
Wannian Zhang
Keyword(s):  
Drug Discovery ◽  
Antifungal Drug

Candidiasis and the impact of flow cytometry on antifungal drug discovery

2017 ◽  
Vol 12 (11) ◽  
pp. 1127-1137
Author(s):  
Tsun Sheng N. Ku ◽  
Stella Bernardo ◽  
Carla J. Walraven ◽  
Samuel A. Lee
Keyword(s):  
Flow Cytometry ◽  
Drug Discovery ◽  
Antifungal Drug ◽  
The Impact

scholarly journals Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

2019 ◽  
Vol 173 ◽  
pp. 117-153 ◽  
Author(s):  
Wan-Yin Fang ◽  
L. Ravindar ◽  
K.P. Rakesh ◽  
H.M. Manukumar ◽  
C.S. Shantharam ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Critical Review ◽  
Pharmaceutical Applications ◽  
Synthetic Approaches

scholarly journals Special Issue: Novel Antifungal Drug Discovery

2016 ◽  
Vol 2 (4) ◽  
pp. 33 ◽  
Author(s):  
Maurizio Del Poeta
Keyword(s):  
Drug Discovery ◽  
Antifungal Drug ◽  
Special Issue

scholarly journals Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis

2016 ◽  
Vol 12 ◽  
pp. 2325-2342 ◽  
Author(s):  
Darcy J Atkinson ◽  
Briar J Naysmith ◽  
Daniel P Furkert ◽  
Margaret A Brimble
Keyword(s):  
Natural Products ◽  
Amino Acid ◽  
Drug Discovery ◽  
Peptide Antibiotic ◽  
Peptide Antibiotics ◽  
Global Public Health ◽  
Development Of Resistance ◽  
Wide Range ◽  
Imminent Threat ◽  
Synthetic Approaches

Rising resistance to current clinical antibacterial agents is an imminent threat to global public health and highlights the demand for new lead compounds for drug discovery. One such potential lead compound, the peptide antibiotic teixobactin, was recently isolated from an uncultured bacterial source, and demonstrates remarkably high potency against a wide range of resistant pathogens without apparent development of resistance. A rare amino acid residue component of teixobactin, enduracididine, is only known to occur in a small number of natural products that also possess promising antibiotic activity. This review highlights the presence of enduracididine in natural products, its biosynthesis together with a review of analogues of enduracididine. Reported synthetic approaches to the cyclic guanidine structure of enduracididine are discussed, illustrating the challenges encountered to date in the development of efficient synthetic routes to facilitate drug discovery efforts inspired by the discovery of teixobactin.

scholarly journals Antifungal Drug Discovery: Something Old and Something New

2012 ◽  
Vol 8 (9) ◽  
pp. e1002870 ◽  
Author(s):  
Arielle Butts ◽  
Damian J. Krysan
Keyword(s):  
Drug Discovery ◽  
Antifungal Drug

scholarly journals 1,2,3-Triazoles: Synthesis and Biological Application

2020 ◽  
Author(s):  
Abdul Aziz Ali
Keyword(s):  
Drug Discovery ◽  
Supramolecular Chemistry ◽  
Organic Synthesis ◽  
Chemical Biology ◽  
Materials Science ◽  
Biological Activities ◽  
Fluorescent Imaging ◽  
Polymer Chemistry ◽  
Privileged Structure ◽  
Synthetic Approaches

Among nitrogen-containing heterocyclic compounds, 1,2,3-triazoles are privileged structure motif and received a great deal of attention in academics and industry. Even though absent in nature, 1,2,3-triazoles have found broad applications in drug discovery, organic synthesis, polymer chemistry, supramolecular chemistry, bioconjugation, chemical biology, fluorescent imaging, and materials science. Therefore, the development of facile and straightforward methodology for the synthesis of 1,2,3-triazoles is of noteworthy interest. In this study, emphasis will be given to numerous synthetic approaches for the synthesis of 1,2,3-triazoles, especially the popular click chemistry approach. Furthermore, several biological activities of this promising heterocycle will also be discussed.

Chapter 17. Progress in antifungal drug discovery

2003 ◽  
pp. 163-172 ◽  
Author(s):  
Mark B. Anderson ◽  
Terry Roemer ◽  
Robyn Fabrey
Keyword(s):  
Drug Discovery ◽  
Antifungal Drug
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