Whole Body Choice Reaction Time (WBCRT-C1) to Detect Cognitive Impairment in Patients with Depressive Disorder (DD): A Case-Control Study

2021 ◽  
Vol 17 ◽  
Author(s):  
Vitthal Khode ◽  
Girish Babu ◽  
Arun Gadad ◽  
Satish Patil ◽  
Komal Ruikar ◽  
...  
Keyword(s):  
Reaction Time ◽  
Depressive Disorder ◽  
Choice Reaction Time ◽  
Case Control Study ◽  
Reaction Times ◽  
Case Control ◽  
Cognitive Testing ◽  
Whole Body ◽  
Central Processing ◽  
Control Study

Background: Depressive disorder (DD) is a state of multiple neuro-psychological deficits. cognitive testing has proven beneficial in guiding treatment of depression. Since these neuro-cognitive testings require great deal of time and skill, measuring Reaction time (RT) can prove an alternative method of measure of cognition. RT is a sensitive tool to measure attention and execution. In our study whole body choice reaction time (WBCRT) is divided in to 2 chronoscopic readings WBCRT-C1and WBCRT-C2. WBCRT-C1 measures time required for central processing in the central nervous system which includes cognition and WBCRT-C2 measures total RT includes central processing and peripheral processing. Objectives: Objective of the study was to measure and compare WBCRT-C1 in DD and controls, and to assess the correlation between WBCRT-C1 with MMSE and HAM-A score. Methods: Hospital based case-control study was conducted on total 68 young subjects, 34 subjects of DD aged between 18-45yrs their reaction times were compared with similar number of age and sex matched controls. Results: WBCRT-C1 was more delayed in patients of DD (807±245 ms) than in controls (579±99ms). A significant correlation was found between WBCRT-C1 and MMSE (r=-0.7371, p=0.0001), HAM-A scores (r=0.3395 p=0.0046). Conclusion: WBCRT-C1 could be a quantitative tool to assess cognitive dysfunction in DD.

scholarly journals Correlating cognition and cortical excitability with pain in fibromyalgia: a case control study

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Vikas Kumar Tiwari ◽  
Srishti Nanda ◽  
Suvercha Arya ◽  
Uma Kumar ◽  
Ratna Sharma ◽  
...  
Keyword(s):  
Reaction Time ◽  
Sleep Quality ◽  
Daytime Sleepiness ◽  
Case Control Study ◽  
Color Word ◽  
Case Control ◽  
Corticomotor Excitability ◽  
Word Task ◽  
Control Study

Abstract Background Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal symptoms, primarily attributed to sensitization of somatosensory system carrying pain. Few reports have investigated the impact of fibromyalgia symptoms on cognition, corticomotor excitability, sleepiness, and the sleep quality — all of which can deteriorate the quality of life in fibromyalgia. However, the existing reports are underpowered and have conflicting directions of findings, limiting their generalizability. Therefore, the present study was designed to compare measures of cognition, corticomotor excitability, sleepiness, and sleep quality using standardized instruments in the recruited patients of fibromyalgia with pain-free controls. Methods Diagnosed cases of fibromyalgia were recruited from the Rheumatology department for the cross-sectional, case-control study. Cognition (Mini-Mental State Examination, Stroop color-word task), corticomotor excitability (Resting motor threshold, Motor evoked potential amplitude), daytime sleepiness (Epworth sleepiness scale), and sleep quality (Pittsburgh sleep quality index) were studied according to the standard procedure. Results Thirty-four patients of fibromyalgia and 30 pain-free controls were recruited for the study. Patients of fibromyalgia showed decreased cognitive scores (p = 0.05), lowered accuracy in Stroop color-word task (for color: 0.02, for word: 0.01), and prolonged reaction time (< 0.01, < 0.01). Excessive daytime sleepiness in patients were found (< 0.01) and worsened sleep quality (< 0.01) were found. Parameters of corticomotor excitability were comparable between patients of fibromyalgia and pain-free controls. Conclusions Patients of fibromyalgia made more errors, had significantly increased reaction time for cognitive tasks, marked daytime sleepiness, and impaired quality of sleep. Future treatment strategies may include cognitive deficits and sleep disturbances as an integral part of fibromyalgia management.

scholarly journals Temperament and character traits in major depressive disorder: a case control study

2017 ◽  
Vol 135 (5) ◽  
pp. 469-474 ◽  
Author(s):  
Barbara Schwair Nogueira ◽  
Renerio Fraguas Júnior ◽  
Isabela Martins Benseñor ◽  
Paulo Andrade Lotufo ◽  
Andre Russowsky Brunoni
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Case Control Study ◽  
Case Control ◽  
Character Traits ◽  
Major Depressive ◽  
Control Study
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