scholarly journals Note on Regulatory Toxicology Requirements for Adjuvants and Vaccines; in View of the Newly Established WHO Guidelines

2015 ◽  
Author(s):  
Mineo Matsumoto ◽  
Shinichi Komatsu
Keyword(s):  
Who Guidelines ◽  
Regulatory Toxicology

A Machine Learning Application for Raising WASH Awareness in the Times of COVID-19 Pandemic (Preprint)

2020 ◽  
Author(s):  
Rohan Pandey ◽  
Vaibhav Gautam ◽  
Ridam Pal ◽  
Harsh Bandhey ◽  
Lovedeep Singh Dhingra ◽  
...  
Keyword(s):  
Machine Learning ◽  
Natural Language Processing ◽  
Natural Language ◽  
Machine Translation ◽  
Language Processing ◽  
User Feedback ◽  
Who Guidelines ◽  
The Times ◽  
The Right ◽  
Local Languages

BACKGROUND The COVID-19 pandemic has uncovered the potential of digital misinformation in shaping the health of nations. The deluge of unverified information that spreads faster than the epidemic itself is an unprecedented phenomenon that has put millions of lives in danger. Mitigating this ‘Infodemic’ requires strong health messaging systems that are engaging, vernacular, scalable, effective and continuously learn the new patterns of misinformation. OBJECTIVE We created WashKaro, a multi-pronged intervention for mitigating misinformation through conversational AI, machine translation and natural language processing. WashKaro provides the right information matched against WHO guidelines through AI, and delivers it in the right format in local languages. METHODS We theorize (i) an NLP based AI engine that could continuously incorporate user feedback to improve relevance of information, (ii) bite sized audio in the local language to improve penetrance in a country with skewed gender literacy ratios, and (iii) conversational but interactive AI engagement with users towards an increased health awareness in the community. RESULTS A total of 5026 people who downloaded the app during the study window, among those 1545 were active users. Our study shows that 3.4 times more females engaged with the App in Hindi as compared to males, the relevance of AI-filtered news content doubled within 45 days of continuous machine learning, and the prudence of integrated AI chatbot “Satya” increased thus proving the usefulness of an mHealth platform to mitigate health misinformation. CONCLUSIONS We conclude that a multi-pronged machine learning application delivering vernacular bite-sized audios and conversational AI is an effective approach to mitigate health misinformation. CLINICALTRIAL Not Applicable

scholarly journals 2020 WHO guidelines on physical activity and sedentary behavior

2021 ◽  
Author(s):  
Anthony D. Okely ◽  
Anna Kontsevaya ◽  
Johan Ng ◽  
Chalchisa Abdeta
Keyword(s):  
Physical Activity ◽  
Sedentary Behavior ◽  
Who Guidelines

Proof of Concept: The Use of Whole-Slide Images (WSI) for Peer Review of Tissues on Routine Regulatory Toxicology Studies

2021 ◽  
pp. 019262332098325
Author(s):  
Alys E. Bradley ◽  
Maurice G. Cary ◽  
Kaori Isobe ◽  
Stuart Naylor ◽  
Stephen Drew
Keyword(s):  
Peer Review ◽  
Proof Of Concept ◽  
Regulatory Toxicology ◽  
Glass Slides ◽  
Microscopic Findings ◽  
Slight Discrepancy ◽  
Whole Slide Images ◽  
Diagnostic Discrepancies

This Proof of Concept (POC) study was to assess whether assessment of whole slide images (WSI) of the 2 target tissues for a contemporaneous peer review can elicit concordant results to the findings generated by the Study Pathologist from the glass slides. Well-focused WSI of liver and spleen from 4 groups of mice, that had previously been diagnosed to be the target tissues by an experienced veterinary toxicologic pathologist examining glass slides, were independently reviewed by 3 veterinary pathologists with varying experience in assessment of WSIs. Diagnostic discrepancies were then reviewed by an experienced adjudicating pathologist. Assessment of microscopic findings using WSI showed concordance with the glass slides, with only slight discrepancy in severity grades noted. None of the lesions recorded by the Study pathologist were “missed” and no lesions were added by the pathologists evaluating WSIs, thus demonstrating equivalence of the WSI to glass slides for this study.

scholarly journals Identifying factors that influenced wellbeing and learning effectiveness during the sudden transition into eLearning due to the COVID-19 lockdown

Work ◽  
2021 ◽  
Vol 68 (1) ◽  
pp. 45-67
Author(s):  
Alessandro Naddeo ◽  
Rosaria Califano ◽  
Iolanda Fiorillo
Keyword(s):  
Coming Out ◽  
Online Courses ◽  
Learning Effectiveness ◽  
Who Guidelines ◽  
Human Comfort ◽  
Factors Influencing ◽  
Rapid Changes ◽  
Sudden Transition ◽  
Teaching Learning ◽  
Educational Delivery

BACKGROUND: The sanitary emergency due to COVID-19 virus obliged people to face up several changes in their everyday life becauseWorld Health Organisation (WHO) guidelines and countries' Health Systems imposed lockdown of activities and social distancing to flatten the infection curve. One of these rapid changes involved students and professors that had to turn the traditional "in presence" classes into online courses facing several problems for educational delivery. OBJECTIVES: This work aimed to investigate the factors that affected both teaching/learning effectiveness and general human comfort and wellbeing after the sudden transition from classrooms to eLearning platforms due to COVID-19 in Italy. METHODS: A workshop, involving students and experts of Human Factors and Ergonomics, has been performed to identify aspects/factors that could influence online learning. Then, from workshop output and literature studies, a survey composed of two questionnaires (one for students and one for teachers) has been developed and spread out among Italian universities students and professors. RESULTS: 700 people answered the questionnaires. Data have been analysed and discussed to define the most important changes due to the new eLearning approach. Absence of interactions with colleagues and the necessity to use several devices were some of the aspects coming out from questionnaires. CONCLUSIONS: The study shows an overview of factors influencing both teaching/learning effectiveness and general human comfort and wellbeing. Results could be considered as a basis for future investigation and optimization about the dependencies and correlations among identified factors and the characteristics of the products/interaction/environment during eLearning courses.

Relevance of Animal Studies in Regulatory Toxicology: Current Approaches and Future Opportunities

1996 ◽  
Vol 24 (2) ◽  
pp. 173-178
Author(s):  
Johannes J.M. van de Sandt ◽  
Victor J. Feron
Keyword(s):  
Risk Assessment ◽  
Risk Evaluation ◽  
Animal Studies ◽  
Regulatory Toxicology ◽  
Animal Test ◽  
Toxicity Studies ◽  
Increasing Knowledge ◽  
Scientific Value

With rapidly increasing knowledge of toxicological processes, the scientific value and relevance of toxicity studies for risk assessment must be re-evaluated. In this paper, it is proposed that the rigid risk evaluation currently required should be replaced by a more flexible, case-by-case approach, in order to increase the relevance of each animal test conducted. The development of new types of toxicity studies and their application in risk evaluation are also described.

scholarly journals Has the COVID 19 Virus Changed Adherence to Hand Washing among Healthcare Workers?

2021 ◽  
Vol 11 (4) ◽  
pp. 53
Author(s):  
Rosalia Ragusa ◽  
Marina Marranzano ◽  
Alessandro Lombardo ◽  
Rosalba Quattrocchi ◽  
Maria Alessandra Bellia ◽  
...  
Keyword(s):  
Hand Hygiene ◽  
Healthcare Workers ◽  
Hand Washing ◽  
World Health ◽  
Patient Contact ◽  
Who Guidelines ◽  
Descriptive Data ◽  
Different Types ◽  
Health Organization ◽  
Hospital Wards

The aim of the study was to assess adherence to hand washing by healthcare workers (HCWs) and its variations over time in hospital wards. We wanted to check whether the pandemic had changed the behavior of HCWs. The study was conducted between 1 January 2015, and 31 December 2020. The HCWs were observed to assess their compliance with the Five Moments for Hand Hygiene. We described the percentage of adherence to World Health Organization (WHO) guidelines stratified per year, per specialty areas, per different types of HCWs. We also observed the use of gloves. Descriptive data were reported as frequencies and percentages. We observed 13,494 hand hygiene opportunities. The majority of observations concerned nurses who were confirmed as the category most frequently involved with patients. Hospital’s global adherence to WHO guidelines did not change in the last six years. During the pandemic, the rate of adherence to the procedure increased significantly only in Intensive Care Unit (ICU). In 2020, the use of gloves increased in pre-patient contact. The hand-washing permanent monitoring confirmed that it is very difficult to obtain the respect of correct hand hygiene in all opportunities, despite the ongoing pandemic and the fear of contagion.

WHO guidelines presage US biosimilars legislation?

2009 ◽  
Vol 27 (11) ◽  
pp. 963-964 ◽  
Author(s):  
John Hodgson
Keyword(s):  
Who Guidelines
Sign in / Sign up

Export Citation Format

Share Document