scholarly journals Heme oxygenase and its role in defense system ; Paradigm shift of anti-inflammatory therapy

2007 ◽  
Vol 30 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Akihiro YACHIE
Keyword(s):  
Heme Oxygenase ◽  
Paradigm Shift ◽  
Defense System ◽  
Anti Inflammatory ◽  
System Paradigm

scholarly journals Community self-organization system: Paradigm shift and strategy in preserving city history

2021 ◽  
Vol 780 (1) ◽  
pp. 012060
Author(s):  
M Sutrisno ◽  
M Syuaib ◽  
Nuryuningsih ◽  
A G Yudhitya
Keyword(s):  
Paradigm Shift ◽  
Self Organization ◽  
City History ◽  
System Paradigm

Heme oxygenase-1 mediates the anti-inflammatory effect of mushroom Phellinus linteus in LPS-stimulated RAW264.7 macrophages

2006 ◽  
Vol 106 (3) ◽  
pp. 364-371 ◽  
Author(s):  
Byung-Chul Kim ◽  
Joung-Woo Choi ◽  
Hye-Young Hong ◽  
Sin-Ae Lee ◽  
Suntaek Hong ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Phellinus Linteus ◽  
Raw264.7 Macrophages ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Role of nuclear factor-κ B and heme oxygenase-1 in the mechanism of action of an anti-inflammatory chalcone derivative in RAW 264.7 cells

2004 ◽  
Vol 142 (7) ◽  
pp. 1191-1199 ◽  
Author(s):  
María José Alcaraz ◽  
Ana María Vicente ◽  
Amparo Araico ◽  
José N Dominguez ◽  
María Carmen Terencio ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Mechanism Of Action ◽  
Raw 264.7 Cells ◽  
Heme Oxygenase 1 ◽  
Raw 264.7 ◽  
Nuclear Factor ◽  
Chalcone Derivative ◽  
Anti Inflammatory ◽  
Nuclear Factor Κ B

scholarly journals Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

Antioxidants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 540 ◽  
Author(s):  
Frank A. D. T. G. Wagener ◽  
Peter Pickkers ◽  
Stephen J. Peterson ◽  
Stephan Immenschuh ◽  
Nader G. Abraham
Keyword(s):  
Critically Ill ◽  
Heme Oxygenase ◽  
Heme Proteins ◽  
Distress Syndrome ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Proof Of Concept ◽  
Effector Molecules ◽  
Free Heme ◽  
Anti Inflammatory

SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) are often critically ill and show lung injury and hemolysis. Heme is a prosthetic moiety crucial for the function of a wide variety of heme-proteins, including hemoglobin and cytochromes. However, injury-derived free heme promotes adhesion molecule expression, leukocyte recruitment, vascular permeabilization, platelet activation, complement activation, thrombosis, and fibrosis. Heme can be degraded by the anti-inflammatory enzyme heme oxygenase (HO) generating biliverdin/bilirubin, iron/ferritin, and carbon monoxide. We therefore postulate that free heme contributes to many of the inflammatory phenomena witnessed in critically ill COVID-19 patients, whilst induction of HO-1 or harnessing heme may provide protection. HO-activity not only degrades injurious heme, but its effector molecules possess also potent salutary anti-oxidative and anti-inflammatory properties. Until a vaccine against SARS-CoV-2 becomes available, we need to explore novel strategies to attenuate the pro-inflammatory, pro-thrombotic, and pro-fibrotic consequences of SARS-CoV-2 leading to morbidity and mortality. The heme-HO system represents an interesting target for novel “proof of concept” studies in the context of COVID-19.

scholarly journals Shepherd’s Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-κB Pathways and Heme Oxygenase-1 Activation

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Jinming Peng ◽  
Tianyong Hu ◽  
Jin Li ◽  
Jing Du ◽  
Kerui Zhu ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Chemical Constituents ◽  
Chemical Compounds ◽  
Heme Oxygenase 1 ◽  
Mice Model ◽  
Traditional Herbal Medicine ◽  
Raw 264.7 Macrophages ◽  
Antioxidative Effects ◽  
Anti Inflammatory

Shepherd’s purse (Capsella bursa-pastoris (L.) Medik.), a wild herb as a traditional herbal medicine, has been proved with multiple healthy benefits. In this study, the chemical constituents of shepherd’s purse were identified by UPLC-QTOF-MS/MS. The antioxidative and anti-inflammatory potential of shepherd’s purse extract (SPE) were also investigated applying lipopolysaccharide- (LPS-) induced inflammation in RAW 264.7 macrophages and a carrageenan-induced mice paw edema model. Twenty-four chemical compounds were identified mainly including phenolic acids and flavonoids. The data also indicated SPE inhibited the productions of NO, PGE2, TNF-α, and IL-6 stimulated with LPS. In addition, SPE inhibited the increase of reactive oxygen species (ROS) and upregulated the expression of heme oxygenase-1 (HO-1). We further found that SPE inhibited the phosphorylation of P38 MAPK and activation of NF-κB. In vivo mice model also indicated that SPE showed strong antioxidative and anti-inflammatory activity.

Isoliquiritigenin, from Dalbergia odorifera, up-regulates anti-inflammatory heme oxygenase-1 expression in RAW264.7 macrophages

2009 ◽  
Vol 58 (5) ◽  
pp. 257-262 ◽  
Author(s):  
S. H. Lee ◽  
J. Y. Kim ◽  
G. S. Seo ◽  
Y.-C. Kim ◽  
D. H. Sohn
Keyword(s):  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Raw264.7 Macrophages ◽  
Anti Inflammatory ◽  
Dalbergia Odorifera
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