Informativeness of phenotypic features of connective tissue dysplasia in children with peritoneal adhesions

Connective tissue dysplasia can be realized with a large number of clinical variants, and accordingly, excessive postoperative adhesion formation can be considered as a manifestation of dysplastic-dependent processes. In the predominant number of surveyed children (93.8%) CTD has developed on the background of existing connective tissue dysplasia syndrome, i.e. the presence of external signs of this condition may serve as a predictor of postoperative complications of adhesions in children.Direct correlation between the number of CTD phenotypic characters and the prevalence of intra-abdominal adhesions was determined. In our view, it allows to detect children at risk of peritoneal adhesions on the basis of external features that can be identified during general examination and do not require additional time or equipment. Accordingly, the surgical treatment of children with signs of CTD syndrome requires an integrated approach and the application of measures to prevent excessive adhesion formation, including intraoperative use of anti-adhesive gels.

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Clinical variants of dyspepsia syndrome in patients with connective tissue dysplasia

Therapy ◽

10.18565/therapy.2019.3.20-25 ◽

2019 ◽

Vol 3_2019 ◽

pp. 20-25

Author(s):

Nechaeva G.I. Nechaeva ◽

Rozhkova M.Yu Rozhkova ◽

Tereshchenko Yu.V. Tereshchenko ◽

Sbitneva L.V. Sbitneva ◽

Silvanovich S.V. Silvanovich ◽

...

Keyword(s):

Connective Tissue ◽

Clinical Variants ◽

Connective Tissue Dysplasia

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Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/1740317 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 7

Author(s):

Guangbing Wei ◽

Yunhua Wu ◽

Qi Gao ◽

Cancan Zhou ◽

Kai Wang ◽

...

Keyword(s):

Adhesion Formation ◽

Major Complication ◽

Chinese Herbs ◽

Postoperative Adhesion ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Abdominal Adhesions ◽

Abdominal Adhesion ◽

Naturally Occurring ◽

Oral Doses

Background. Postoperative intra-abdominal adhesions are a major complication after abdominal surgery. Although various methods have been used to prevent and treat adhesions, the effects have not been satisfactory. Emodin, a naturally occurring anthraquinone derivative and an active ingredient in traditional Chinese herbs, exhibits a variety of pharmacological effects. In our study, we demonstrated the effect of emodin treatment on preventing postoperative adhesion formation. Materials and Methods. A total of 48 rats were divided into six groups. Abdominal adhesions were created by abrasion of the cecum and its opposite abdominal wall. In the experimental groups, the rats were administered daily oral doses of emodin. On the seventh day after operation, the rats were euthanized, and blood and pathological specimens were collected. Abdominal adhesion formation was evaluated by necropsy, pathology, immunohistochemistry, Western blot, and enzyme-linked immunosorbent assay analyses. Results. Abdominal adhesions were markedly reduced by emodin treatment. Compared with the control group, collagen deposition was reduced and the peritoneal mesothelial completeness rate was higher in the emodin-treated groups. Emodin had anti-inflammatory effects, reduced oxidative stress, and promoted the movement of the intestinal tract (P<0.05). Conclusion. Emodin significantly reduced intra-abdominal adhesion formation in a rat model.

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Clinical variants of dyspepsia syndrome in patients with connective tissue dysplasia

Therapy ◽

10.18565/therapy.2019.3.20-24 ◽

2019 ◽

Vol 3_2019 ◽

pp. 20-24

Author(s):

Nechaeva G.I. Nechaeva ◽

Rozhkova M.Yu Rozhkova ◽

Tereshchenko Yu.V. Tereshchenko ◽

Sbitneva L.V. Sbitneva ◽

Silvanovich S.V. Silvanovich ◽

...

Keyword(s):

Connective Tissue ◽

Clinical Variants ◽

Connective Tissue Dysplasia

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Features of choroidal blood flow and their influence on formation of peripheral retinal degenerations in school-age children with undifferentiated connective tissue dysplasia

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-1-141-144 ◽

2021 ◽

pp. 141-144

Author(s):

V.V. Li ◽

Keyword(s):

Connective Tissue ◽

Choroidal Thickness ◽

School Age Children ◽

Comparative Characteristic ◽

Frequency Of Occurrence ◽

School Age ◽

Phenotypic Characters ◽

Retinal Degenerations ◽

Connective Tissue Dysplasia ◽

Progressive Myopia

Purpose. To study choroidal thickness (CT) and assess its effect on frequency of occurrence dangerous types of peripheral retinal degenerations (PRD) in school-age children with myopia associated with undifferentiated connective tissue dysplasia (UCTD). Material and methods. The object of study was 62 children (124 eyes) aged 10–15 years (mean age 12.3±0.8 years) with progressive myopia associated with moderate (48 people, 77.4%) and pronounced (14 people, 22.6%) degree of UCTD. Special ophthalmologic examination included macular imaging by optical coherence tomography (RTVue 100, «Optovue», USA) to measure CT. Diagnostic criteria by T.M. Milkovskaya-Dimitrova et al (1987) were used to identify phenotypic characters of UCTD. Results. Comparative characteristic of CT in macula showed high (p <0.05) relationship between the blood-filled of choroidal vessels and degree of UCTD. Analysis frequency of occurrence of PRD depending on CT demonstrated that against the background accumulation of phenotypic characters of UCTD increase in frequency of occurrence of PRD was observed. Statistical analysis confirmed presence of significant negative correlation between decrease CT and increase in incidence of prognostically dangerous forms of PRD. Conclusion. It was found that in school-age children with myopia with increase degree of UCTD, CT decreases. With choroidal thinning in children with myopia associated with UCTD, the frequency of occurrence dangerous forms of PRD increases. The research results are of clinical importance for the development of rational approaches to clinical examination and treatment children with school myopia with clinical signs of UCTD. Key words: progressive myopia, undifferentiated connective tissue dysplasia, choroidal thickness, peripheral retinal degeneration, rhegmatogenous retinal detachment.

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Effects of methylene blue, indigo carmine solution and autologous erythrocyte suspension on formation of adhesions after injection into rats

Reproduction ◽

10.1530/reprod/120.2.225 ◽

2000 ◽

pp. 225-229 ◽

Cited By ~ 5

Author(s):

A Gul ◽

C Kotan ◽

I Dilek ◽

T Gul ◽

A Tas ◽

...

Keyword(s):

Methylene Blue ◽

Macrophage Activation ◽

Indigo Carmine ◽

Adhesion Formation ◽

Albino Rats ◽

Erythrocyte Suspension ◽

Peritoneal Adhesions ◽

Tubal Patency ◽

Macrophage Activity ◽

Group Score

The aim of this study was to determine whether autologous erythrocyte suspension can be used as a dye for evaluation of tubal patency and whether it has any advantages over methylene blue or indigo carmine solutions. Reproductively healthy female nulliparous Wistar Albino rats (n = 30), aged 6 months, mass 165-195 g, were assigned randomly to three groups. Rats received a 1 ml i.p. injection of 5% (w/v) methylene blue solution (methylene blue group: n = 10), 5% (w/v) indigo carmine solution (indigo carmine group: n = 10) or 5% (v/v) fresh autologous erythrocyte suspension (autologous erythrocyte group: n = 10). At 4 weeks after injection, a small sterile opening was made in the peritoneal cavity of each rat. The cavity was rinsed once with TCM-199 to collect macrophages. The rinsed peritoneal contents were cultured overnight to evaluate macrophage activation. The peritoneal opening was expanded for evaluation of adhesion formation. Only one rat from the autologous erythrocyte group had intra-peritoneal adhesions (score 2), whereas all rats in the methylene blue group (score 1: n = 1; score 2: n = 4; score 3: n = 4; and score 4: n = 1) and seven rats in the indigo carmine group (score 1: n = 1; score 2: n = 2; score 3: n = 3; and score 4: n = 1) had intra-abdominal adhesions. Macrophage activity was observed in the cultured peritoneal contents collected from the methylene blue and indigo carmine groups but not from the autologous erythrocyte group. Adhesion formation could be due to macrophage activation caused by methylene blue and indigo carmine solutions. These results indicate that tubal patency can be observed by laparoscopy using autologous erythrocyte suspension. The results of this study are believed to be the first to indicate that a patient's own erythrocyte suspension could be used during observation of tubal patency by laparoscopy. However, further studies are required.

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