scholarly journals Effect of Urtica dioica hydroalcoholic extract on liver inflammatory factors in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate

2017 ◽  
Vol 4 (2) ◽  
pp. 181-188
Author(s):  
Akram Tayanloo ◽  
Samad Zare1 ◽  
Latifeh Karimzadeh-Bardei ◽  
Serwa Hoseini ◽  
◽  
...  
Keyword(s):  
Wistar Rats ◽  
Polycystic Ovarian Syndrome ◽  
Urtica Dioica ◽  
Inflammatory Factors ◽  
Estradiol Valerate ◽  
Hydroalcoholic Extract ◽  
Ovarian Syndrome

scholarly journals Effect of bee venom on IL-6, COX-2 and VEGF levels in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate

2013 ◽  
Vol 19 (1) ◽  
pp. 32 ◽  
Author(s):  
Latifeh Karimzadeh ◽  
Mohammad Nabiuni ◽  
Homa Kouchesfehani ◽  
Hamed Adham ◽  
Amir Bagheri ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Polycystic Ovarian Syndrome ◽  
Bee Venom ◽  
Estradiol Valerate ◽  
Cox 2 ◽  
Ovarian Syndrome

41. Anti-Inflammatory Effect of Honey Bee Venom on Wistar Rats Induced Poly Cystic Ovarian Syndrome by Estradiol Valerate

Toxicon ◽  
2012 ◽  
Vol 60 (2) ◽  
pp. 115-116
Author(s):  
Mohammad Nabiuni ◽  
Kazem Parivar ◽  
Bahman Zeynali ◽  
Azar Sheikholeslami ◽  
Latifeh Karimzadeh
Keyword(s):  
Honey Bee ◽  
Wistar Rats ◽  
Bee Venom ◽  
Estradiol Valerate ◽  
Anti Inflammatory ◽  
Ovarian Syndrome ◽  
Inflammatory Effect

scholarly journals Pharmacological sympathetic denervation prevents the development of polycystic ovarian syndrome in rats injected with estradiol valerate

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Julieta A. Espinoza ◽  
Wendy Alvarado ◽  
Berenice Venegas ◽  
Roberto Domínguez ◽  
Leticia Morales-Ledesma
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Sympathetic Denervation ◽  
Estradiol Valerate ◽  
Ovarian Syndrome

scholarly journals A study of comparison of effectiveness of letrozole (5mg) versus clomephene citrate (100 mg) for ovulation induction among infertile women

2021 ◽  
Vol 8 (4) ◽  
pp. 553-558
Author(s):  
Manish R Pandya ◽  
Khushbu Patel
Keyword(s):  
Aromatase Inhibitor ◽  
Ovulation Induction ◽  
Polycystic Ovarian Syndrome ◽  
Clomiphene Citrate ◽  
Estradiol Valerate ◽  
Infertile Women ◽  
Group A ◽  
Group B ◽  
Ovarian Syndrome ◽  
Anovulatory Infertility

Clomiphene citrate has been traditionally used as the drug of the choice for treatment of women with anovulatory infertility. In the last decade, an aromatase inhibitor, letrozole has emerged as an alternative ovulation induction agent among anovulatory women with polycystic ovarian syndrome. Letrozole has a definitive role in anovulatory women who have not responded to the clomiphene citrate therapy is confirmed by literatures. Anovulatory dysfunction is a common problem and is responsible for about 40% of female infertility and among causes; PCOS (polycystic ovarian syndrome) is the leading cause. Clomiphene citrate is considered as the drug of choice for the first line treatment of anovulatory dysfunction for a variety of reasons. Clomiphene citrate has some side effects like multi-follicular development and cyst formation and resistance of clomiphene are areas of concern and desire for an effective alternative persists.An aromatase inhibitor, letrozole, was introduced into infertility practice in the year 2000 and is regarded as a second line option, particularly in women with clomiphene resistance, and it has found acceptance in various clinical situations and the indications for use have expanded., To compare the efficacy of letrozole and clomiphene citrate (CC) for ovulation induction in infertile women. The study included 100 women presented with anovulatory infertility. The infertile women were divided into 2 groups of 50: Group A received 100 mg Clomiphene Citrate from day 3 to day 5 of menstruation and Estradiol Valerate 4 mg on the 12 day of menstruation until 16 day of menstruation; Group B treated by 5 mg Letrozole from day 3 to day 5 of the menstruation and as Group A, Estradiol Valerate 4 mg on the 12 day of menstruation until 16 day of menstruation given to Group B, with visits to determine ovulation and pregnancy, followed by tracking of pregnancies. Participants were of 20 to 39 years age, had normal uterine cavity and had a male partner with a sperm concentration of at least 14 million per millilitre; and during the study the women and their partners agreed to have regular intercourse with the intent of conception. The live birth during the treatment period was the primary outcome. Women who received letrozole had more cumulative live births than those women who had received clomiphene citrate (36 out of 50 [72%] vs. 28 out of 50 [56%]), without significant differences in overall congenital anomalies, there were no congenital anomalies. With letrozole as compared to clomiphene the cumulative ovulation rate was higher. Higher incidence of hot flushes was associated with a clomiphene, and letrozole was associated with fatigue and dizziness. Rates of other adverse effects were almost similar among these 2 groups. A significant difference in the follicular and endometrial development was evident among these 2 groups. As compared to with clomiphene, an aromatase inhibitor, letrozole was associated with higher live-birth and ovulation rates among infertile women. The results of the study demonstrated letrozole to be superior to clomiphene citrate in the maintenance of endometrial thickness.

Phytoestrogenic Effects of Various Levels of Soy Isoflavones in Polycystic Ovarian Syndrome

2020 ◽  
Author(s):  
Nishaf Mazhar ◽  
Mehr Un Nisa ◽  
Muhammad Sajid Arshad
Keyword(s):  
Lipid Profile ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Hormones ◽  
Nutrient Digestibility ◽  
Soy Isoflavones ◽  
Female Rats ◽  
Estradiol Valerate ◽  
Randomized Design ◽  
Daily Body Weight ◽  
Ovarian Syndrome

Abstract Background: Soy isoflavones (SI) has estrogenic effect in tissues by binding to estrogen receptors and might be beneficial for women with Polycystic Ovarian Syndrome (PCOS) by reduction in testosterone, cholesterol , Insulin , weight gain, inflammatory markers and oxidative stress. Methods: The study was plane to examine the effect of various levels of SI on nutrient intake, digestibility, lipid profile, insulin and reproductive hormones of estradiol-valerate (4mg/rat/IM) PCOS induced rat models. Thirty-Six Wistar 45 days old rats weighing 95 ± 5g were divided into 4 groups, each having 9 rats: C (control: without SF), SF10 (SF 0.10g/Kg BW), SF15 (SF 0.15g/Kg BW) and SF20 (SF 0.20g/Kg BW). SF was given through the oral gavage. Food and water were offered ad libitum and intake was recorded daily. Body weight was recorded on weekly basis. During last week of trial, collected feces by total collection method and blood samples were used to calculate nutrient digestibility and biochemical analysis respectively. The Completely Randomized Design and LSD test were used to analyze the data. Results: The significant results were observed in female rats fed SF10, SF15 and SF20 compared to C. Estrogen, progesterone and prolactin were (P<0.05) high in rats fed SF diet that was 4 and 30% increase from C respectively. Insulin, Testosterone, FSH and LH were lowest in rats fed diet SF20. Significant (P<0.05) reduction in cholesterol was observed in rats fed SF15 and SF20 as compared to C. Serum HDL was improved (P<0.05) in all SIF 0.10 , SIF 0.15 and SIF 0.20 as 26.88±1.59 (mg/dl), 32.40±1.42 (mg/dl) and 53.44±1.50 (mg/dl) in comparison to PC. Serum LDL was significantly reduced to 68.89±4.36 (mg/dl) in SIF 0.20 , and to 108.20±4.14 (mg/dl) in SIF 0.15 whereas, insignificant reduction was observed in SIF 0.10 (127.75±4.62 mg/dl) as compared to PC. Highly significant reduction was noted in triglycerides level in SIF 0.20 as 115.00±2.04 (mg/dl), however, significant reduction was observed in both SIF 0.10 and SIF 0.15 as compared to PC after three months of treatment with soy isoflavones.Conclusions: It is concluded that soy isoflavones have potential role on reproductive hormones, insulin levels, weight, lipid profile and nutrient digestibility in PCOS induced rats.

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