scholarly journals Photodynamic Therapy Mediated by a Novel Chlorin Derivative, TONS 501-Na, in EMT6 cells

2017 ◽  
Vol 37 (4) ◽  
pp. 1723-1728 ◽  
Keyword(s):  
Photodynamic Therapy ◽  
Chlorin Derivative

Synthesis and in vitro photodynamic therapy of chlorin derivative 131-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a

2017 ◽  
Vol 87 ◽  
pp. 263-273 ◽  
Author(s):  
Jianjun Cheng ◽  
Wenting Li ◽  
Guanghui Tan ◽  
Zhiqiang Wang ◽  
Shuying Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Pyropheophorbide A ◽  
Chlorin Derivative

Antitumor activity of photodynamic therapy with a chlorin derivative in vitro and in vivo

Tumor Biology ◽  
2015 ◽  
Vol 36 (9) ◽  
pp. 6839-6847 ◽  
Author(s):  
Lai-Xing Wang ◽  
Jian-Wei Li ◽  
Jian-Yue Huang ◽  
Jian-Hong Li ◽  
Li-Jun Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Antitumor Activity ◽  
Chlorin Derivative

Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility

2016 ◽  
Vol 14 (14) ◽  
pp. 3608-3613 ◽  
Author(s):  
Atsushi Narumi ◽  
Takahiro Tsuji ◽  
Kosuke Shinohara ◽  
Hiromi Yamazaki ◽  
Moriya Kikuchi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Solubility ◽  
Third Generation ◽  
Chlorin Derivative

A chlorin derivative was encircled with four maltotriose (Mal3) molecules to produce an oligosaccharide-conjugate meeting the requirements of a third generation photodynamic therapy (PDT) photosensitizer.

Nanoparticles of Lyotropic Liquid Crystals: A Novel Strategy for the Topical Delivery of a Chlorin Derivative for Photodynamic Therapy of Skin Cancer

2013 ◽  
Vol 9 (4) ◽  
pp. 434-441 ◽  
Author(s):  
Raquel Petrilli ◽  
Fabiola Praca ◽  
Aline Regina Carollo ◽  
Wanessa Medina ◽  
Kleber Thiago Oliveira ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Liquid Crystals ◽  
Skin Cancer ◽  
Topical Delivery ◽  
Lyotropic Liquid Crystals ◽  
Novel Strategy ◽  
Chlorin Derivative

scholarly journals In vitro and in vivo antitumor activity of a novel chlorin derivative for photodynamic therapy

Neoplasma ◽  
2016 ◽  
Vol 63 (01) ◽  
pp. 37-43 ◽  
Author(s):  
C. Y. ZHANG ◽  
L. J. ZHANG ◽  
J. W. LI ◽  
J. H. LI ◽  
Z. M. WU ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Antitumor Activity ◽  
In Vivo Antitumor Activity ◽  
Chlorin Derivative

scholarly journals The anti-cancer potency of photodynamic therapy of a novel chlorin derivative Amidochlorin p6 (ACP)

RSC Advances ◽  
2017 ◽  
Vol 7 (65) ◽  
pp. 40873-40880 ◽  
Author(s):  
Hongyue Zhang ◽  
Wenting Li ◽  
Guanghui Tan ◽  
Guohua Ding ◽  
Zhiqiang Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cell Viability ◽  
Hela Cells ◽  
Anti Cancer ◽  
Chlorin Derivative

Amidochlorin p6 (ACP) was uptaken by HeLa cells, showing excellent phototoxicity (the cell viability was 21% at a concentration of 8 μmol L−1), resulting in cell death.

scholarly journals Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo

2015 ◽  
Vol 08 (01) ◽  
pp. 1540003 ◽  
Author(s):  
Li-Jun Zhang ◽  
Lai-Xing Wang ◽  
Wei-Li Zhang ◽  
Yi-Jia Yan ◽  
Zhi-Long Chen
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Nude Mice ◽  
Absorption Peak ◽  
Long Wavelength ◽  
Wavelength Absorption ◽  
Chlorin Derivative

In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25 mW/cm2, 1.2 to 3.6 J/cm2) and destroy Eca-109 tumor in nude mice (50 mW/cm2, 90 J/cm2). It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation.

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