Gastric Emptying Improved Significantly After PRG Compared to Billroth-I Reconstruction: Assessment of Gastric Emptying With a 13C-Breath Test

Background: The use of totally laparoscopic surgery with Billroth-I reconstruction (delta-shaped anastomosis) has rapidly become widespread in recent years. However, we experienced delayed gastric emptying (DGE) in the early period after introduction of this technique. To the best of our knowledge, there are no report mentioned the incision line to prevent DGE in distal gastrectomy. In the present study, we standardized the surgical techniques, including the gastric incision line and compared the short-term results before and after standardization. Methods: A total of 86 patients were enrolled in this study. 28 procedures were performed in the early period and 58 procedures were performed in the late period, and the 2 groups were compared retrospectively. Results: The operation time decreased significantly after standardization from 288 min to 224 min (P < 0.001). The median value of perioperative bleeding volume reduced from 22.5 mL to 12.5 mL (P =0.060). There were no postoperative complications related to the site of anastomosis in either group. 5 cases of DGE (17.8%) was noted in the early period, but only 2 cases (3.4%) in the late period (P =0.022). Conclusions: Standardization of the incision line after laparoscopic gastrectomy resulted in a decline in incidence of DGE.

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The relationship between 13C-acid octanoic breath test and scintigraphy in the evaluation of gastric emptying is affected by scintigraphic labeling technique

Gastroenterology ◽

10.1016/s0016-5085(01)82306-4 ◽

2001 ◽

Vol 120 (5) ◽

pp. A465-A465

Author(s):

D PINTO ◽

M GIOVANNAMARRA ◽

V STANGHELLINI ◽

M MARENGO ◽

N MONETTI ◽

...

Keyword(s):

Gastric Emptying ◽

Breath Test ◽

The Relationship

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13C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer®): Toward standardization for testing gastric emptying of solids

Digestive and Liver Disease ◽

10.1016/j.dld.2010.01.001 ◽

2010 ◽

Vol 42 (8) ◽

pp. 549-553 ◽

Cited By ~ 27

Author(s):

Francesco Perri ◽

Massimo Bellini ◽

Piero Portincasa ◽

Andrea Parodi ◽

Patrizia Bonazzi ◽

...

Keyword(s):

Gastric Emptying ◽

Test Meal ◽

Breath Test ◽

Octanoic Acid

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Effect of meal size and test duration on gastric emptying as determined by breath test in normal subjects using a muffin meal labeled with 13C-sodium octanoate

Gastroenterology ◽

10.1016/s0016-5085(00)82651-7 ◽

2000 ◽

Vol 118 (4) ◽

pp. A143

Author(s):

Sutep Gonlachanvit ◽

Henry P. Parkman ◽

William D. Chey ◽

Keith J. Goodman

Keyword(s):

Gastric Emptying ◽

Breath Test ◽

Normal Subjects ◽

Meal Size ◽

Test Duration ◽

Sodium Octanoate

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Effect of body size on gastric emptying using the 13C-octanoic acid breath test

Journal of Small Animal Practice ◽

10.1111/j.1748-5827.2004.tb00252.x ◽

2004 ◽

Vol 45 (8) ◽

pp. 386-389 ◽

Cited By ~ 4

Author(s):

P. S. Yam ◽

J. McLellan ◽

C. Wyse ◽

S. W. J. Reid ◽

J. Cooper ◽

...

Keyword(s):

Body Size ◽

Gastric Emptying ◽

Breath Test ◽

Octanoic Acid

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A Stable Isotope Breath Test With a Standard Meal for Abnormal Gastric Emptying of Solids in the Clinic and in Research

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2008.01.009 ◽

2008 ◽

Vol 6 (6) ◽

pp. 635-643.e1 ◽

Cited By ~ 110

Author(s):

Lawrence A. Szarka ◽

Michael Camilleri ◽

Adrian Vella ◽

Duane Burton ◽

Kari Baxter ◽

...

Keyword(s):

Gastric Emptying ◽

Stable Isotope ◽

Breath Test ◽

Standard Meal

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Plasma GLP-1 response to oral and intraduodenal nutrients in health and type 2 diabetes – impact on gastric emptying

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab828 ◽

2021 ◽

Author(s):

Cong Xie ◽

Weikun Huang ◽

Linda E Watson ◽

Stijn Soenen ◽

Richard L Young ◽

...

Keyword(s):

Type 2 Diabetes ◽

Gastric Emptying ◽

Breath Test ◽

Oral Glucose ◽

Gastric Emptying Rate ◽

Postprandial Glycemia ◽

Glucagon Like Peptide 1 ◽

The Relationship ◽

Potato Meal

Abstract Context Both gastric emptying and the secretion of glucagon-like peptide-1 (GLP-1) are major determinants of postprandial glycemia in health and type 2 diabetes (T2D). GLP-1 secretion after a meal is dependent on the entry of nutrients into the small intestine, which, in turn, slows gastric emptying. Objective To define the relationship between gastric emptying and the GLP-1 response to both oral and small intestinal nutrients in subjects with and without T2D. Design We evaluated: (i) the relationship between gastric emptying (breath test) and postprandial GLP-1 levels after a mashed potato meal in 73 T2D subjects; (ii) inter-individual variations in GLP-1 response to (a) intraduodenal glucose (4kcal/min) during euglycemia and hyperglycemia in 11 healthy, and 12 T2D, subjects, (b) intraduodenal fat (2kcal/min) in 15 T2D subjects, and (c) intraduodenal protein (3kcal/min) in 10 healthy subjects; and (iii) the relationship between gastric emptying (breath test) of 75g oral glucose and the GLP-1 response to intraduodenal glucose (4kcal/min) in 21 subjects (9 healthy, 12 T2D). Results The GLP-1 response to the mashed potato meal was unrelated to the gastric half-emptying time (T50). The GLP-1 responses to intraduodenal glucose, fat and protein varied substantially between individuals, but intra-individual variation to glucose was modest. The T50 of oral glucose was related directly to the GLP-1 response to intraduodenal glucose (r=0.65, P=0.002). Conclusions In a given individual, gastric emptying is not a determinant of the postprandial GLP-1 response. However, the intrinsic gastric emptying rate is determined in part by the responsiveness of GLP-1 to intestinal nutrients.

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