Cognitive, Behavioral, and Psychiatric Symptoms in Two Children with Agenesis of the Corpus Callosum: Case Report

2003 ◽  
Vol 33 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Humberto C. Párraga ◽  
Marianela I. Párraga ◽  
Alicia R. Jensen
Keyword(s):  
Corpus Callosum ◽  
Psychiatric Symptoms ◽  
Incidental Finding ◽  
Behavior Disorder ◽  
Cognitive Behavioral ◽  
Agenesis Of Corpus Callosum ◽  
Normal Intelligence ◽  
Hyperactivity Disorder ◽  
Behaviorally Disturbed ◽  
And Behavior

Objective: To report two children, with normal intelligence, referred for evaluation of complex cognitive, behavioral, and psychiatric problems, in which Agenesis of Corpus Callosum (ACC) was an incidental finding. Method: Case descriptions are used and a comprehensive differential diagnosis made with previous diagnoses of partial complex seizures (PCS), psychosis, anxiety, attention deficit hyperactivity disorder (ADHD), and behavior disorder. Results: Due to the presence of multiple biopsychosocial interactions a multimodal intervention including pharmacological, behavioral, psychotherapeutic, and social approaches was implemented, with good results. Conclusion: These cases underscore the importance of conducting a comprehensive neuropsychiatric evaluation in children with severe behavior problems and other confusing symptoms. Since the incidence of ACC in behaviorally disturbed children, with normal intelligence, is unknown, physicians must accept that a reasonable degree of suspicion is warranted. Further studies are needed to facilitate physicians' awareness.

Agenesis of Corpus Callosum and Dementia of the Alzheimer'S Type: a review and Case Report

1994 ◽  
Vol 39 (7) ◽  
pp. 429-432 ◽  
Author(s):  
Natalie Rasgon ◽  
Jambur Ananth ◽  
Ismael Mena ◽  
Boyd Krout ◽  
Kyle Boone
Keyword(s):  
Corpus Callosum ◽  
Incidental Finding ◽  
Neuropsychological Testing ◽  
Normal Functioning ◽  
Agenesis Of Corpus Callosum ◽  
Recent Onset ◽  
Normal Limits ◽  
Clinical Interest ◽  
Spect Scan ◽  
Tomography Scan

This paper describes a previously sufficiently functioning 57 year old man who presented with a recent onset of frontal behaviour. Partial agenesis of corpus callosum was an incidental finding on a computerized tomography scan. The EEG was within normal limits and neuropsychological testing did not reveal any interhemispheric disconnection. A SPECT-Scan revealed bilateral hypoperfusion, consistent with Alzheimer's dementia. Normal functioning up to 50 years of age and a later manifestation of Alzheimer's disease along with agenesis of carpus callosum is of clinical interest as such an association has not been published.

Attention Deficit and Disruptive Behavior Disorder Symptoms

2001 ◽  
Vol 17 (1) ◽  
pp. 25-35 ◽  
Author(s):  
G. Leonard Burns ◽  
James A. Walsh ◽  
David R. Patterson ◽  
Carol S. Holte ◽  
Rita Sommers-Flanagan ◽  
...  
Keyword(s):  
Attention Deficit ◽  
Rating Scales ◽  
Behavior Disorder ◽  
Disruptive Behavior Disorder ◽  
Subjective Rating ◽  
Time Interval ◽  
Assessment Procedure ◽  
Frequency Count ◽  
Hyperactivity Disorder ◽  
Oppositional Defiant

Summary: Rating scales are commonly used to measure the symptoms of attention deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD). While these scales have positive psychometric properties, the scales share a potential weakness - the use of vague or subjective rating procedures to measure symptom occurrence (e. g., never, occasionally, often, and very often). Rating procedures based on frequency counts for a specific time interval (e. g., never, once, twice, once per month, once per week, once per day, more than once per day) are less subjective and provide a conceptually better assessment procedure for these symptoms. Such a frequency count procedure was used to obtain parent ratings on the ADHD, ODD, and CD symptoms in a normative (nonclinical) sample of 3,500 children and adolescents. Although the current study does not provide a direct comparison of the two types of rating procedures, the results suggest that the frequency count procedure provides a potentially more useful way to measure these symptoms. The implications of the results are noted for the construction of rating scales to measure the ADHD, ODD, and CD symptoms.

scholarly journals Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
J. Ellegood ◽  
S. P. Petkova ◽  
A. Kinman ◽  
L. R. Qiu ◽  
A. Adhikari ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Ex Vivo ◽  
Chromatin Modification ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Social Deficits ◽  
Altered Expression ◽  
Developmental Growth ◽  
And Behavior

Abstract Background One of the causal mechanisms underlying neurodevelopmental disorders (NDDs) is chromatin modification and the genes that regulate chromatin. AT-rich interactive domain 1B (ARID1B), a chromatin modifier, has been linked to autism spectrum disorder and to affect rare and inherited genetic variation in a broad set of NDDs. Methods A novel preclinical mouse model of Arid1b deficiency was created and validated to characterize and define neuroanatomical, behavioral and transcriptional phenotypes. Neuroanatomy was assessed ex vivo in adult animals and in vivo longitudinally from birth to adulthood. Behavioral testing was also performed throughout development and tested all aspects of motor, learning, sociability, repetitive behaviors, seizure susceptibility, and general milestones delays. Results We validated decreased Arid1b mRNA and protein in Arid1b+/− mice, with signatures of increased axonal and synaptic gene expression, decreased transcriptional regulator and RNA processing expression in adult Arid1b+/− cerebellum. During neonatal development, Arid1b+/− mice exhibited robust impairments in ultrasonic vocalizations (USVs) and metrics of developmental growth. In addition, a striking sex effect was observed neuroanatomically throughout development. Behaviorally, as adults, Arid1b+/− mice showed low motor skills in open field exploration and normal three-chambered approach. Arid1b+/− mice had learning and memory deficits in novel object recognition but not in visual discrimination and reversal touchscreen tasks. Social interactions in the male–female social dyad with USVs revealed social deficits on some but not all parameters. No repetitive behaviors were observed. Brains of adult Arid1b+/− mice had a smaller cerebellum and a larger hippocampus and corpus callosum. The corpus callosum increase seen here contrasts previous reports which highlight losses in corpus callosum volume in mice and humans. Limitations The behavior and neuroimaging analyses were done on separate cohorts of mice, which did not allow a direct correlation between the imaging and behavioral findings, and the transcriptomic analysis was exploratory, with no validation of altered expression beyond Arid1b. Conclusions This study represents a full validation and investigation of a novel model of Arid1b+/− haploinsufficiency throughout development and highlights the importance of examining both sexes throughout development in NDDs.

scholarly journals One-year randomized trial comparing virtual reality-assisted therapy to cognitive–behavioral therapy for patients with treatment-resistant schizophrenia

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Laura Dellazizzo ◽  
Stéphane Potvin ◽  
Kingsada Phraxayavong ◽  
Alexandre Dumais
Keyword(s):  
Virtual Reality ◽  
Cognitive Behavioral Therapy ◽  
Psychiatric Symptoms ◽  
Behavioral Therapy ◽  
Controlled Trial ◽  
Comparative Trial ◽  
Cognitive Behavioral ◽  
Treatment Resistant ◽  
Auditory Verbal Hallucinations

AbstractThe gold-standard cognitive–behavioral therapy (CBT) for psychosis offers at best modest effects. With advances in technology, virtual reality (VR) therapies for auditory verbal hallucinations (AVH), such as AVATAR therapy (AT) and VR-assisted therapy (VRT), are amid a new wave of relational approaches that may heighten effects. Prior trials have shown greater effects of these therapies on AVH up to a 24-week follow-up. However, no trial has compared them to a recommended active treatment with a 1-year follow-up. We performed a pilot randomized comparative trial evaluating the short- and long-term efficacy of VRT over CBT for patients with treatment-resistant schizophrenia. Patients were randomized to VRT (n = 37) or CBT (n = 37). Clinical assessments were administered before and after each intervention and at follow-up periods up to 12 months. Between and within-group changes in psychiatric symptoms were assessed using linear mixed-effects models. Short-term findings showed that both interventions produced significant improvements in AVH severity and depressive symptoms. Although results did not show a statistically significant superiority of VRT over CBT for AVH, VRT did achieve larger effects particularly on overall AVH (d = 1.080 for VRT and d = 0.555 for CBT). Furthermore, results suggested a superiority of VRT over CBT on affective symptoms. VRT also showed significant results on persecutory beliefs and quality of life. Effects were maintained up to the 1-year follow-up. VRT highlights the future of patient-tailored approaches that may show benefits over generic CBT for voices. A fully powered single-blind randomized controlled trial comparing VRT to CBT is underway.

scholarly journals Transsellar trans-sphenoidal encephalocele with cleft lip, cleft palate and agenesis of corpus callosum

2021 ◽  
Vol 16 (8) ◽  
pp. 2211-2213
Author(s):  
Prajina Pradhan ◽  
Subash Phuyal ◽  
Ritesh Lamsal ◽  
Pooja Agrawal ◽  
Raju Paudel
Keyword(s):  
Corpus Callosum ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Agenesis Of Corpus Callosum

scholarly journals A Case Report of a Prenatally Missed Mowat-Wilson Syndrome With Isolated Corpus Callosum Agenesis

2021 ◽  
Vol 8 ◽  
pp. 2329048X2110065
Author(s):  
Nesrin Şenbil ◽  
Zeynep Arslan ◽  
Derya Beyza Sayın Kocakap ◽  
Yasemin Bilgili
Keyword(s):  
Corpus Callosum ◽  
Autosomal Dominant ◽  
Genetic Disorder ◽  
Gene Mutations ◽  
Hirschsprung Disease ◽  
Agenesis Of Corpus Callosum ◽  
Whole Exome ◽  
Congenital Cardiac Anomalies ◽  
History Of ◽  
Gene Mutation Analysis

Mowat–Wilson syndrome (MWS) is an autosomal dominant genetic disorder caused by ZEB2 gene mutations, manifesting with unique facial characteristics, moderate to severe intellectual problems, and congenital malformations as Hirschsprung disease, genital and ophthalmological anomalies, and congenital cardiac anomalies. Herein, a case of 1-year-old boy with isolated agenesis of corpus callosum (IACC) in the prenatal period is presented. He was admitted postnatally with Hirschsprung disease (HSCR), hypertelorism, uplifted earlobes, deeply set eyes, frontal bossing, oval-shaped nasal tip, ‘‘M’’ shaped upper lip, opened mouth and prominent chin, and developmental delay. Hence, MWS was primarily considered and confirmed by the ZEB2 gene mutation analysis. His karyotype was normal. He had a history of having a prenatally terminated brother with similar features. Antenatally detected IACC should prompt a detailed investigation including karyotype and microarray; even if they are normal then whole exome sequencing (WES) should be done.

scholarly journals Psychotherapy for child and adolescent with psychiatric disorder attending in National Institute of Mental Health, Dhaka

2017 ◽  
Vol 28 (2) ◽  
pp. 53-57
Author(s):  
Md Zahir Uddin ◽  
Muhammad Zillur Rahman Khan ◽  
Mumita Jerin Nilav ◽  
Md Faruq Alam ◽  
Md Abdul Mohit
Keyword(s):  
Mental Health ◽  
Psychiatric Disorder ◽  
Behavior Therapy ◽  
Conversion Disorder ◽  
Dropout Rate ◽  
Child And Adolescent ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Hyperactivity Disorder ◽  
And Behavior

Psychotherapy for child and adolescent with psychiatric disorder is relatively a newer concept in Bangladesh. This cross sectional study was done to determine the pattern of psychotherapy provided by the psychotherapy department for children and adolescents with psychiatric disorder in National Institute of Mental Health (NIMH) from June 2010 to November 2014. Total 121 samples were taken purposefully from the records of psychotherapy department where data were collected retrospectively using check list. Results showed that among respondents more were boys than girls (64.5% vs. 35.5%) whereas their mean (±SD) age was 12.1 (±3.2) years. Majority (47.9%) of them were within class six to class ten. Most of the respondents (89%) were referred from the outpatient department and 11% were referred by inpatient department. Conduct disorder (27.3%), conversion disorder (13.2%), attention deficit hyperactivity disorder (12.4%) and intellectual developmental disorder (9.1%) were common diagnoses of the respondents. It was found that 74.4% respondents attended up to one to five psychotherapy sessions and cognitive behavior therapy (38%) and behavior therapy (25.6%) were most commonly used psychotherapy. Though 60.3% of the respondents improved to certain extent in psychotherapy sessions, patient’s dropout rate was found as 55.4%.Bang J Psychiatry Dec 2014; 28(2): 53-57

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