scholarly journals Living With Inflammatory Bowel Disease: Protocol for a Longitudinal Study of Factors Associated With Symptom Exacerbations (Preprint)

2018 ◽  
Author(s):  
Kelcie Witges ◽  
Laura E Targownik ◽  
Clove Haviva ◽  
John R Walker ◽  
Lesley A Graff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Psychological Functioning ◽  
Intestinal Inflammation ◽  
Disease Course ◽  
Web Based ◽  
Factors Associated ◽  
Symptom Exacerbation ◽  
Inflammatory Bowel

BACKGROUND There has been limited longitudinal research that has comprehensively evaluated possible factors in the exacerbation of inflammatory bowel disease (IBD) symptoms with or without associated inflammation. Evolving Web-based technologies facilitate frequent monitoring of patients’ experiences and allow a fine-grained assessment of disease course. OBJECTIVE We aimed to prospectively identify factors associated with symptom exacerbation and inflammation in IBD including psychological functioning, diet, health behaviors, and medication adherence. METHODS Between June 2015 and May 2017, we enrolled adults with IBD, recruited from multiple sources, who had been symptomatically active at least once within the prior 2 years. They completed a Web-based survey every 2 weeks for 1 year and submitted a stool sample at baseline, 26 weeks, and 52 weeks. Any participant reporting a symptom exacerbation was matched to a control within the cohort, based on disease type, sex, age, and time of enrollment; both were sent a supplemental survey and stool collection kit. Biweekly surveys included validated measures of the disease course, psychological functioning, health comorbidities, and medication use. Intestinal inflammation was identified through fecal calprotectin (positive level >250 μg/g stool). RESULTS There were 155 participants enrolled with confirmed IBD, 66.5% (103/155) with Crohn disease and 33.5% (52/155) with ulcerative colitis, of whom 98.7% (153/155) completed the study. Over the 1-year period, 47.7% (74/155) participants experienced a symptom exacerbation. The results of analyses on risk factors for symptom exacerbations are pending. CONCLUSIONS We recruited and retained a longitudinal IBD cohort that will allow the determination of risk factors for symptom exacerbation with and without inflammation. This will increase understanding of symptom exacerbations among persons with IBD. INTERNATIONAL REGISTERED REPOR RR1-10.2196/11317

scholarly journals Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease

2020 ◽  
Vol 27 (1) ◽  
pp. 58-64
Author(s):  
Heather Carney ◽  
Ruth Ann Marrie ◽  
James M Bolton ◽  
Scott B Patten ◽  
Lesley A Graff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Substance Use ◽  
Anxiety Disorder ◽  
Bowel Disease ◽  
Inflammatory Diseases ◽  
Primary Care Providers ◽  
Care Providers ◽  
Factors Associated ◽  
Inflammatory Bowel

Abstract Background Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort. Methods Inflammatory bowel disease participants (n = 247) were recruited via hospital- and community-based gastroenterology clinics, a population-based IBD research registry, and primary care providers as part of a larger cohort study of psychiatric comorbidity in immune-mediated inflammatory diseases. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV was administered to participants to identify lifetime SUD, anxiety disorder, and major depressive disorder. Additional questionnaires regarding participants’ sociodemographic and clinical characteristics were also completed. We examined demographic and clinical factors associated with lifetime SUD using unadjusted and adjusted logistic regression modeling. Results Forty-one (16.6%) IBD participants met the criteria for a lifetime diagnosis of an SUD. Factors associated with elevated odds of SUD were ever smoking (adjusted odds ratio [aOR], 2.96; 95% confidence interval [CI], 1.17–7.50), male sex (aOR, 2.44; 95% CI, 1.11–5.36), lifetime anxiety disorder (aOR, 2.41; 95% CI, 1.08–5.37), and higher pain impact (aOR, 1.08; 95% CI, 1.01–1.16). Conclusions One in six persons with IBD experienced an SUD, suggesting that clinicians should maintain high index of suspicion regarding possible SUD, and inquiries about substance use should be a part of care for IBD patients, particularly for men, smokers, and patients with anxiety disorders and pain.

scholarly journals Risk factors of work disability in patients with inflammatory bowel disease — A Dutch nationwide web-based survey

2014 ◽  
Vol 8 (7) ◽  
pp. 590-597 ◽  
Author(s):  
Mirthe E. van der Valk ◽  
Marie-Josée J. Mangen ◽  
Max Leenders ◽  
Gerard Dijkstra ◽  
Ad A. van Bodegraven ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Work Disability ◽  
Web Based ◽  
Inflammatory Bowel

scholarly journals Diagnostic Delay in Romanian Patients with Inflammatory Bowel Disease: Risk Factors and Impact on the Disease Course and Need for Surgery

2015 ◽  
Vol 10 (3) ◽  
pp. 306-314 ◽  
Author(s):  
Roxana Zaharie ◽  
Alina Tantau ◽  
Florin Zaharie ◽  
Marcel Tantau ◽  
Liana Gheorghe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Risk ◽  
Diagnostic Delay ◽  
Disease Course ◽  
Inflammatory Bowel

Sa509 RISK FACTORS ASSOCIATED WITH FAMILIAL INFLAMMATORY BOWEL DISEASE

2021 ◽  
Vol 160 (6) ◽  
pp. S-528
Author(s):  
Catarina F. Gomes ◽  
Camilla Bjorn Jensen ◽  
Kristine Allin ◽  
Joana Torres ◽  
Johan M. Burisch
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Factors Associated ◽  
Inflammatory Bowel

Cannabis Use in Persons With Inflammatory Bowel Disease and Vulnerability to Substance Misuse

2019 ◽  
Vol 26 (9) ◽  
pp. 1401-1406 ◽  
Author(s):  
Tawnya M Hansen ◽  
Brigitte C Sabourin ◽  
Banke Oketola ◽  
Charles N Bernstein ◽  
Harminder Singh ◽  
...  
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Logistic Regression ◽  
Depressive Symptoms ◽  
Bowel Disease ◽  
Substance Misuse ◽  
Cannabis Use ◽  
Factors Associated ◽  
Inflammatory Bowel

Abstract Background It is unknown whether cannabis users self-medicating their inflammatory bowel disease (IBD) symptoms are more likely to have comorbid mental health or personality risk factors associated with an increased potential for substance misuse compared with recreational cannabis users. Methods We surveyed individuals with IBD about their cannabis use, their mental health symptoms, and personality risk factors associated with substance misuse. We compared risk factors for substance misuse between individuals using cannabis to manage IBD symptoms and those using cannabis recreationally. Results Of 201 persons with IBD who completed the questionnaire, 108 reported lifetime cannabis use. Of those, a larger proportion of Crohn’s disease patients used cannabis to manage IBD symptoms (53% [34/64] vs 28% [12/43]; P = 0.010). Individuals self-medicating with cannabis were more likely to use cannabis for coping reasons (P = 0.016) and demonstrated higher levels of impulsivity (P = 0.004) and depressive symptoms (P = 0.012) when compared with individuals using cannabis recreationally. Logistic regression revealed that cannabis was 4.1 times (P = 0.05) and 3.7 times (P = 0.05) more likely to be used for IBD symptoms by smokers and individuals with moderate–severe depressive symptoms, respectively. Individuals high in impulsivity were 4.1 times more likely to use cannabis for their IBD symptoms than those low in impulsivity (P = 0.005). Conclusions Persons with IBD self-medicating with cannabis have characteristics associated with increased vulnerability to substance misuse when compared with those using cannabis recreationally. Screening for mental health comorbidities and vulnerability to substance misuse should be undertaken if cannabis is to be used to treat IBD symptoms.

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