Risk factors of work disability in patients with inflammatory bowel disease — A Dutch nationwide web-based survey

BACKGROUND There has been limited longitudinal research that has comprehensively evaluated possible factors in the exacerbation of inflammatory bowel disease (IBD) symptoms with or without associated inflammation. Evolving Web-based technologies facilitate frequent monitoring of patients’ experiences and allow a fine-grained assessment of disease course. OBJECTIVE We aimed to prospectively identify factors associated with symptom exacerbation and inflammation in IBD including psychological functioning, diet, health behaviors, and medication adherence. METHODS Between June 2015 and May 2017, we enrolled adults with IBD, recruited from multiple sources, who had been symptomatically active at least once within the prior 2 years. They completed a Web-based survey every 2 weeks for 1 year and submitted a stool sample at baseline, 26 weeks, and 52 weeks. Any participant reporting a symptom exacerbation was matched to a control within the cohort, based on disease type, sex, age, and time of enrollment; both were sent a supplemental survey and stool collection kit. Biweekly surveys included validated measures of the disease course, psychological functioning, health comorbidities, and medication use. Intestinal inflammation was identified through fecal calprotectin (positive level >250 μg/g stool). RESULTS There were 155 participants enrolled with confirmed IBD, 66.5% (103/155) with Crohn disease and 33.5% (52/155) with ulcerative colitis, of whom 98.7% (153/155) completed the study. Over the 1-year period, 47.7% (74/155) participants experienced a symptom exacerbation. The results of analyses on risk factors for symptom exacerbations are pending. CONCLUSIONS We recruited and retained a longitudinal IBD cohort that will allow the determination of risk factors for symptom exacerbation with and without inflammation. This will increase understanding of symptom exacerbations among persons with IBD. INTERNATIONAL REGISTERED REPOR RR1-10.2196/11317

Download Full-text

A cross-sectional study on the risk factors for Inflammatory Bowel Disease among medical students and interns in Saudi Arabia.

International Journal of Medicine in Developing Countries ◽

10.24911/ijmdc.51-1554227998 ◽

2019 ◽

pp. 710-715

Author(s):

Talal Alzahrani ◽

Abdullah Aljuaid ◽

Tariq Alharthi ◽

Alwaleed Aljabir ◽

Khaled Alqurashi ◽

...

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Saudi Arabia ◽

Medical Students ◽

Bowel Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Inflammatory Bowel

Download Full-text

Risk factors associated with the negativization of anti-HBs antibodies in inflammatory bowel disease patients

10.26226/morressier.57c5383ed462b80296c9b21c ◽

2016 ◽

Author(s):

Alicia C. Marin

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Factors Associated ◽

Inflammatory Bowel

Download Full-text

Faculty Opinions recommendation of Risk factors for inflammatory bowel disease: A prospective multi-center study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733619737.793573433 ◽

2020 ◽

Author(s):

Gwo-Tzer Ho ◽

Rahul Kalla

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Inflammatory Bowel ◽

Multi Center Study ◽

Center Study

Download Full-text

Sa508 RISK FACTORS FOR INCIDENT INFLAMMATORY BOWEL DISEASE ACCORDING TO DISEASE PHENOTYPE

Gastroenterology ◽

10.1016/s0016-5085(21)01964-8 ◽

2021 ◽

Vol 160 (6) ◽

pp. S-528

Author(s):

Emily W. Lopes ◽

Kristin E. Burke ◽

James Richter ◽

Ashwin Ananthakrishnan ◽

Paul Lochhead ◽

...

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Disease Phenotype ◽

Inflammatory Bowel

Download Full-text

Anti-tumor necrosis factor-induced lupus in patients with inflammatory bowel disease: a hospital-based cohort study from Korea

Therapeutic Advances in Gastroenterology ◽

10.1177/1756284821997794 ◽

2021 ◽

Vol 14 ◽

pp. 175628482199779

Author(s):

Su Jin Choi ◽

Soo Min Ahn ◽

Ji Seon Oh ◽

Seokchan Hong ◽

Chang-Keun Lee ◽

...

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Tumor Necrosis Factor ◽

Bowel Disease ◽

Tumor Necrosis ◽

Cox Regression ◽

Cox Regression Analysis ◽

Inflammatory Bowel ◽

Necrosis Factor ◽

Mucocutaneous Symptoms

Background: Anti-tumor necrosis factor (TNF) agents are increasingly used for rheumatic diseases and inflammatory bowel disease (IBD), but are associated with the development of anti-TNF-induced lupus (ATIL). Nonetheless, few ATIL studies on non-Caucasian IBD patients exist. Here, we investigated the incidence, clinical features, and risk factors of ATIL in Korea. Methods: We retrospectively reviewed the medical records of IBD patients undergoing anti-TNF therapy at our tertiary IBD center between 2008 and 2020. ATIL was diagnosed as a temporal association between symptoms and anti-TNF agents, and the presence of at least one serologic and non-serologic American College of Rheumatology criterion. The risk factors for ATIL occurrence were assessed using multivariate Cox regression analysis. Results: Of 1362 IBD patients treated with anti-TNF agents, 50 (3.7%) ATIL cases were suspected, of which 14 (1.0%) received a definitive diagnosis. Arthritis and mucocutaneous symptoms were observed in 13 and 4 patients, respectively. All ATIL cases were positive for anti-nuclear and anti-dsDNA antibodies. Four patients (30.8%) improved while continuing anti-TNF therapy. At the final follow up, the ATIL group ( n = 14) had a lower IBD remission rate (30.8% versus 68.8%, p = 0.019) than the non-ATIL group ( n = 36). Ulcerative colitis and longer disease duration were associated with ATIL occurrence, with hazard ratios of 7.017 ( p = 0.005) and 1.118 ( p = 0.002), respectively. Conclusion: Although rare, ATIL is associated with poor treatment response to IBD in Korean patients. ATIL should be considered if arthritis and mucocutaneous symptoms develop during anti-TNF therapy for IBD.

Download Full-text