Understanding the associations of prenatal androgen exposure on sleep physiology, circadian proteins, anthropometric parameters, hormonal factors, quality of life and sex among healthy young adults – BOAT international, multicentre study protocol (Preprint)

2021 ◽  
Author(s):  
Wojciech Kuczyński ◽  
Tetsuro Hoshino ◽  
Aleksandra Kudrycka ◽  
Aleksandra Małolepsza ◽  
Urszula Karwowska ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Young Adults ◽  
Phase I ◽  
Finger Length ◽  
Androgen Exposure ◽  
Sleep Physiology ◽  
Prenatal Androgen Exposure ◽  
Prenatal Androgen

UNSTRUCTURED Background The ratio of second finger length to fourth finger length (2D:4D) is considered to be a negative correlate of prenatal androgen exposure and a positive correlate of prenatal oestrogen. Therefore males, on average, have a lower value of 2D:4D ratio as compared to females. Coincidentally, various brain regions are sensitive to prenatal androgen exposure, and their function in adulthood may be influenced by these prenatal actions of sex hormones. An example of such a brain region is the preoptic area which is involved in sleep and sexual functions. The objective of this study is to assess the relationship between prenatal androgen exposure (indicated by the 2D:4D ratio) and various physiological (sex hormone levels, sleep-wake parameters), psychological (mental health), as well as sexual parameters in young healthy adults. Methods The study consists of two phases: 1. In Phase I, we will conduct a survey-based study and anthropometric assessments (including 2D:4D ratio, body mass index) in healthy young adults. Using validated questionnaires, we will collect self-report data on sleep quality, sexual function, sleep chronotype, anxiety and depressive symptoms. 2. In Phase II, a sub-sample of Phase I will have polysomnography, physiological and genetic assessments. The sample recruited to this phase will comprise 100 healthy adults in each institution involved. Sleep architecture data will be obtained using a portable polysomnography. Venous blood will be drawn before and after polysomnograpy night and urine sample will be obtained in the morning. The level of testosterone, estradiol, progesterone, luteinizing hormone, follicle stimulating hormone, prolactin, melatonin and circadian regulatory proteins (CLOCK, TIM, PER) and a few miRNAs expression level, will be measured. The rest and activity cycle will be monitored using an actigraphy for a 7 days period. Discussion The impact of the study may help to better understand the role of plausible prenatal androgen exposure on sleep physiology, mental health and sexual quality of life in young adults.

scholarly journals COST, RESOURCE UTILIZATION, QUALITY OF LIFE, MENTAL HEALTH, AND FINANCIAL TOXICITY AMONG YOUNG ADULTS WITH STROKE IN THE UNITED STATES

2020 ◽  
Vol 75 (11) ◽  
pp. 1838
Author(s):  
Javier Valero Elizondo ◽  
Rohan Khera ◽  
Farhaan Vahidy ◽  
Haider Warraich ◽  
Shiwani Mahajan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
United States ◽  
Young Adults ◽  
Resource Utilization ◽  
The United States ◽  
Financial Toxicity

scholarly journals Mental health, quality of life and social relations in young adults born with low birth weight

2012 ◽  
Vol 10 (1) ◽  
pp. 146 ◽  
Author(s):  
Line K Lund ◽  
Torstein Vik ◽  
Stian Lydersen ◽  
Gro CC Løhaugen ◽  
Jon Skranes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Young Adults ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Social Relations ◽  
Health Quality ◽  
Health Quality Of Life

scholarly journals Factors predicting trial engagement, treatment satisfaction, and health-related quality of life during the iTreAD project: Secondary analysis of an online treatment and social networking trial for binge drinking and depression in young adults. (Preprint)

2020 ◽  
Author(s):  
Samineh Sanatkar ◽  
Milena Heinsch ◽  
Peter Andrew Baldwin ◽  
Mark Rubin ◽  
Frances Kay-Lambkin
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Young Adults ◽  
Alcohol Use ◽  
Treatment Satisfaction ◽  
Health Interventions ◽  
Life Outcomes ◽  
Affective Factors ◽  
Quality Of Life Outcomes

BACKGROUND Mental health and alcohol use problems are among the most common causes of disease burden in young Australians and lead to significant lifetime burden. Yet comorbidity remains significantly underdetected and undertreated in health settings. Digital mental health tools designed to identify at-risk individuals, encourage help-seeking or deliver treatment for comorbidity, have the potential to address this existing service gap. However, despite a strong body of evidence that digital mental health programs provide an effective treatment option for a range of mental health and alcohol use problems in young adults, research shows that uptake rates can be low. It is, thus, important to understand the factors that influence treatment satisfaction and quality of life outcomes for young adults who access eMental health interventions for comorbidity. OBJECTIVE This study sought to understand the factors that influence treatment satisfaction and quality of life outcomes for young adults who access eMental health interventions for comorbid alcohol and mood disorders. The aim was to determine the importance of personality (i.e., Big Five personality traits and intervention attitudes) and affective factors (i.e., depression, anxiety, and stress levels) in predicting intervention trial engagement at sign-up, satisfaction with the online tool, and quality of life at the conclusion of the iTreAD trial (internet Treatment for Alcohol and Depression). METHODS Australian adults (N = 411) aged between 18 and 30 years who screened positive for depression and alcohol use problems signed up to the iTreAD project between August 2014 and October 2015. During registration, participants provided information about their personality, current affective state, treatment expectations and basic demographic information. Subsequent follow-up surveys were used to gauge ongoing trial engagement. The last follow-up questionnaire, completed at 64 weeks, assessed participants’ satisfaction with the online treatment and quality of life experiences. RESULTS Multiple linear regression analyses were employed to detect the relative influence of predictor variables on trial engagement, treatment satisfaction, and quality of life outcomes. Analyses revealed that the overall predictive effects of personality and affective factors were 20% or lower. Conscientiousness, neuroticism, and state-based anxiety constituted unique predictors of engagement with the iTreAD study, and state-based depression uniquely predicted variance in quality of life reports at the time of study completion. None of the selected predictors explained variances in treatment satisfaction. CONCLUSIONS Findings suggest that traditional predictors of engagement observed in face-to-face research may not be easily transferable to digital health interventions, particularly those aimed at comorbid mental health concerns and alcohol misuse among young adults. More research is needed to identify what determines engagement in this cohort in order to optimally design and execute digital intervention studies with multiple treatment aims. CLINICALTRIAL ACTRN12614000310662 INTERNATIONAL REGISTERED REPORT RR2-10.1186/s12889-015-2365-2

The Relation of Digit Ratio (2D:4D) and Absolute Finger Length to Pavlovian Temperament Dimensions

2008 ◽  
Vol 103 (3) ◽  
pp. 783-792 ◽  
Author(s):  
Martin Voracek
Keyword(s):  
Individual Differences ◽  
Digit Ratio ◽  
Left Hand ◽  
Finger Length ◽  
Androgen Action ◽  
Androgen Exposure ◽  
Self Reports ◽  
Prenatal Androgen Exposure ◽  
Strength Of Excitation ◽  
Prenatal Androgen

The associations of digit ratio (2D:4D), a likely marker for prenatal androgen exposure, and absolute finger length, a likely marker for postnatal androgen exposure, with self-reports on three Pavlovian temperament dimensions (strength of excitation, strength of inhibition, and mobility of nervous processes) were investigated in a sample of 84 men and 114 women. In men, left-hand 2D:4D was weakly, but significantly, negatively associated with strength of inhibition, and also weakly negatively, but not significantly, associated with the two other temperament dimensions. These effects were absent for men's right-hand 2D:4D. Finger lengths of both hands in men were weakly, but significantly, positively associated with mobility of nervous processes scores. All associations for women were negligible. Both prenatal and postnatal androgen action may contribute to small amounts of individual differences in Pavlovian temperament dimensions in men but apparently not in women.

Impact of Retinitis Pigmentosa on Quality of Life, Mental Health, and Employment Among Young Adults

2017 ◽  
Vol 177 ◽  
pp. 169-174 ◽  
Author(s):  
Anne Elisabeth Chaumet-Riffaud ◽  
Philippe Chaumet-Riffaud ◽  
Anaelle Cariou ◽  
Céline Devisme ◽  
Isabelle Audo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Young Adults ◽  
Retinitis Pigmentosa

scholarly journals Ecological Momentary Mood, Resilience, and Mental Health Status as Predictors of Quality of Life Among Young Adults Under Stress: A Structural Equation Modeling Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Rachel-Tzofia Sinvani ◽  
Haya Fogel-Grinvald ◽  
Anat Afek ◽  
Rina Ben-Avraham ◽  
Alex Davidov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Young Adults ◽  
Health Status ◽  
Structural Equation ◽  
Mental Health Status ◽  
Equation Modeling ◽  
Psychological Resilience ◽  
Ecological Momentary

Multiple internal factors, such as psychological resilience and mental health status, have been shown to contribute to overall quality of life (QoL). However, very few studies to date have examined how these factors contribute to QoL of youth and young adults in a stressful situation. Here, we studied the contribution of these factors, as well as of ecological momentary mood assessment, to QoL of young army recruits during their Basic Training Combat (BCT). To this end, we collected data from 156 male and female soldiers in a mixed-gender unit in the Israel Defense Forces (IDF). Using a mobile app installed on participants' phones, participants provided self-reports regarding their mental health status and psychological resilience at baseline, and QoL 2 weeks later. Momentary mood reporting was further collected during the 2-week interval period using a daily self-report mood scale (IMS-12). Structural equation modeling (SEM) was used to examine the interrelationships among the study variables based on a hypothesized model. We found that a model with all factors (gender, resilience, mental health status and momentary mood) provided a good fit for the data based on its fit indices [χ2(38) = 47.506, p = 0.139, CFI = 0.979, NFI = 0.910, RMSEA = 0.040, TLI = 0.964]. However, the only direct contributors to QoL were gender and momentary mood, accounting together for 61.5% of the variance of QoL. Psychological resilience and mental health status contributed to QoL only indirectly, through their associations with momentary mood. Collectively, these results highlight the importance of ecological momentary assessment of mental-health related factors such as mood to the prediction of QoL in young adults under stress. These findings may have broader implications for monitoring and improvement of well-being in young healthy populations as well as in clinical ones.

Exploration of alternative digit ratios as a predictor of prostate cancer aggressiveness.

2014 ◽  
Vol 32 (4_suppl) ◽  
pp. 231-231
Author(s):  
Michael Stolten ◽  
Elisa Ledet ◽  
Aryeneesh Dotiwala ◽  
Eric Luk ◽  
A. Oliver Sartor ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Age Of Onset ◽  
Digit Ratio ◽  
Finger Length ◽  
Digit Ratios ◽  
Androgen Exposure ◽  
Cancer Aggressiveness ◽  
Prenatal Androgen Exposure ◽  
Prenatal Androgen ◽  
Androgen Levels

231 Background: During gestation, development of the prostate is dependent on a functional androgen receptor and the presence of dihydrotestosterone. Prenatal androgen exposure has been correlated with a range of diseases including prostate cancer (PCa). Historically, the ratio of the second to the fourth digit (2D:4D) has been linked to prenatal androgen levels; however, the use of alternate finger ratios have been shown to be a greater indicator of prenatal androgen exposure compared to the traditional 2D:4D ratio. Studies have shown that the distal fingertip extent of the second digit (2T:2D) was also associated with prenatal androgens. This study aims to use alternative digit ratio measurements to determine aggressiveness of PCa. Our hypothesis is that alternative digit ratios are more sensitive to prenatal androgen levels, and a better predictor of disease than the traditional 2D:4D ratio. Methods: Digital measurements were made from hand scans of PCa patients. All fingers on the right hand were measured from the basal crease to the fingertip as well as the distal fingertip extent of the second digit. Race, family history (FH) (first degree relatives with PCa), and age at diagnosis were recorded. These clinical covariates were then compared to the finger length ratios which were dichotomized based on the median values and analyzed for possible correlations. Results: Hand measurements were taken on 350 Caucasian (CA) and 100 African American (AA) PCa patients. AA men were more likely to have a smaller 2D:3D (P < 0.0001) and 2D:4D digit ratio (P < 0.0001), and larger 3D:5D (P = 0.0002) and 4D:5D (P = 0.0125) when compared to CA men. AA men with a smaller 2T:2D ratio were younger at the time of diagnosis (P = 0.0446). Additionally, AA men with a larger 2D:5D ratio were more likely to have a FH of PCa (P= 0.0238). Conclusions: Alternative finger length ratios show strong differences between AA and CA men. In AA men, alternative digit ratios are associated with age of PCa diagnosis and FH of PCa. These hypothesis generating results require validation in a larger cohort, but may provide insight to the underlying racial disparity observed in PCa. Finger length may represent a unique, non-invasive predictor of PCa, specifically age of onset and FH in AA men.

Sign in / Sign up

Export Citation Format

Share Document