Phase-Contrast MRI CSF Flow Measurements for the Diagnosis of Normal-Pressure Hydrocephalus: Observer Agreement of Velocity Versus Volume Parameters

2017 ◽  
Vol 208 (4) ◽  
pp. 838-843 ◽  
Author(s):  
Ahmed Mohamed Tawfik ◽  
Lamiaa Elsorogy ◽  
Rabab Abdelghaffar ◽  
Ayman Abdel Naby ◽  
Ibrahim Elmenshawi
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Phase Contrast ◽  
Normal Pressure ◽  
Observer Agreement ◽  
Velocity Versus ◽  
Csf Flow ◽  
Phase Contrast Mri ◽  
Flow Measurements

Measurement of Cerebrospinal Fluid Flow: Technique Validation in a Patient with Idiopathic Normal Pressure Hydrocephalus

2005 ◽  
Vol 18 (1) ◽  
pp. 34-36
Author(s):  
A. Romano ◽  
A. Bozzao ◽  
G. Trillò ◽  
M. Bonamini ◽  
F. Fasoli ◽  
...  
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Phase Contrast ◽  
Normal Pressure ◽  
Third Ventriculostomy ◽  
Csf Flow ◽  
Flow Measurements ◽  
Cerebrospinal Fluid Flow ◽  
Functional Changes ◽  
Before And After ◽  
Long Term Follow Up

This study aimed to assess anatomical and functional changes disclosed by magnetic resonance imaging in a patient with suspect normal pressure hydrocephalus following surgical third ventriculostomy with placement of a ventriculoperitoneal shunt. The patient was investigated by phase contrast sequences to calculate CSF flow in the Sylvian aqueduct before and after the two surgical procedures. In addition, T1-weighted volumetric MPRAGE images were acquired using voxel-based morphometry to study any changes in size of the ventricular system and CSF in the subarachnoid spaces before and after surgery. CSF flow measurements were closely correlated with the patient's clinical course, increased CSF flow coinciding with worsening symptoms, and a decrease in flow noted after surgery. There were no significant changes in the CSF volumes analyzed. Phase contrast technique proved reliable and effective for the purposes of diagnosis and long-term follow-up in patients with suspect normal pressure hydrocephalus eligible for surgery

Indagine dinamica della circolazione liquorale con RM a contrasto di fase. Reperti normali e patologici

1997 ◽  
Vol 10 (2_suppl) ◽  
pp. 39-42
Author(s):  
S. Duca ◽  
S. Crasto ◽  
E. Salzedo ◽  
P. Bertone ◽  
P. Peretta ◽  
...  
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Phase Contrast ◽  
False Negative ◽  
Fluid Motion ◽  
Normal Pressure ◽  
Aqueductal Stenosis ◽  
Csf Flow ◽  
Technical Problems ◽  
Mr Sequences ◽  
Chiari Malformations

The introduction of fluid motion sensitive MR sequences allows a physiologic evaluation of CSF circulation. The authors use a phase contrast MR sequence to evaluate the CSF flow in 48 patients (12 with ventriculostomy, 10 with Chiari malformations, 7 with aqueductal stenosis, 15 with various degrees cranio-ventricular malformatios, 3 with syringomyelia and 3 with normal pressure hydrocephalus.) The technique is particularly useful in the evaluation of the opening of ventriculocisternostomy. Some technical problems that can give a false negative examination are discussed.

scholarly journals Most small cerebral cortical veins demonstrate significant flow pulsatility: a human phase contrast MRI study at 7T

2020 ◽  
Author(s):  
Ian D Driver ◽  
Maarika Traat ◽  
Fabrizio Fasano ◽  
Richard G Wise
Keyword(s):  
Phase Contrast ◽  
Cerebral Arteries ◽  
Normal Pressure ◽  
7 Tesla ◽  
Cerebral Veins ◽  
Phase Contrast Mri ◽  
Venous Flow ◽  
Sagittal Sinus ◽  
Automated Method ◽  
Flow Pulsatility

AbstractPhase contrast MRI has been used to investigate flow pulsatility in cerebral arteries, larger cerebral veins and the cerebrospinal fluid. Such measurements of intracranial pulsatility and compliance are beginning to inform understanding of the pathophysiology of conditions including normal pressure hydrocephalus, multiple sclerosis and dementias. We demonstrate the presence of flow pulsatility in small cerebral cortical veins, for the first time using phase contrast MRI at 7 Tesla, with the aim of improving our understanding of the haemodynamics of this little-studied vascular compartment. An automated method for establishing where venous flow is pulsatile is introduced, revealing significant pulsatility in 116 out of 146 veins, across 8 healthy participants, assessed in parietal and frontal regions. Distributions of pulsatility index and pulse waveform delay were characterized, indicating a small, but statistically significant (p<0.05), delay of 59±41 ms in cortical veins with respect to the superior sagittal sinus, but no differences between veins draining different arterial supply territories. Measurements of pulsatility in smaller cortical veins, a hitherto unstudied compartment closer to the capillary bed, could lead to a better understanding of intracranial compliance and cerebrovascular (patho)physiology.

scholarly journals Associations between blood and cerebrospinal fluid flow impairments assessed with phase-contrast MRI and brain damage in patients with age-related cerebral small vessel disease

2019 ◽  
pp. 16-23
Author(s):  
E.I. Kremneva ◽  
B.M. Akhmetzyanov ◽  
L.A. Dobrynina ◽  
M.V. Krotenkova
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Damage ◽  
Phase Contrast ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Csf Flow ◽  
Phase Contrast Mri ◽  
Vessel Disease ◽  
Age Related

Hemodynamic parameters of blood and cerebrospinal fluid (CSF) flow can be measured in vivo using phase-contrast MRI (PC-MRI). This opens new horizons for studying the mechanisms implicated in the development and progression of age-related cerebral small vessel disease (SVD). In this paper, we analyze associations between cerebral arterial, venous and CSF flow impairments and SVD features visible on MRI. The study was carried out in 96 patients with SVD (aged 60.91 ± 6.57 years) and 23 healthy volunteers (59.13 ± 6.56 years). The protocol of the MRI examination included routine MRI sequences (T2, FLAIR, T1, SWI, and DWI) applied to assess the severity of brain damage according to STRIVE advisory standards and PC-MRI used to quantify blood flow in the major arteries and veins of the neck, the straight and upper sagittal sinuses, and CSF flow at the aqueduct level. We analyzed the associations between linear and volumetric parameters of blood/CSF flow and the degree of brain matter damage using the Fazekas scale. We observed a reduction in tABF, stVBF, sssVBF, aqLF, Saq, and ICC values and a rise in Pi associated with WMH progression, as well as a gradual decline in tABF and an increase in Pi, Saq and ICC associated with a growing number of lacunes (р < 0.05). Patients with early (< 5) MB had lower sssVBF and stVBF rates in comparison with patients without MB; aqLF, Saq, and ICC values were elevated in patients with 5 to 10 MB, as compared to patients without MB or early (< 5) MB. The established associations between MRI findings in patients with SVD and blood/CSF flow impairments suggest the important role of mechanisms implicated in the disruption of Monro–Kellie intracranial homeostasis in promoting SVD.

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