scholarly journals Application of a free radical scavenger edaravone in patients with subarachnoid hemorrhage (review)

2021 ◽  
Vol 17 (7) ◽  
pp. 10-14
Author(s):  
O.A. Halushko ◽  
T.S. Zahranychnyi
Keyword(s):  
Free Radical ◽  
Subarachnoid Hemorrhage ◽  
Hemorrhagic Transformation ◽  
Free Radical Scavenger ◽  
Neurological Deficits ◽  
Radical Scavenger ◽  
Long Term Effects ◽  
Main Effects

Background. The free radical scavenger edaravon helps to reduce the area of ischemic injury and improve the long-term effects of stroke and is therefore widely used in the treatment of ischemic stroke. However, the role of edaravone in the treatment of patients with subarachnoid hemorrhage has not yet been clarified. The purpose was to investigate the feasibility and effectiveness of the use of the free radical scavenger xavron (edaravon) in the treatment of patients with subarachnoid hemorrhage. Materials and methods. A search was conducted for studies and systematic reviews for the keywords: “acute stroke”; “subarachnoid hemorrhage”, “hemorrhagic transformation”, “edaravon” in the Google Scholar database published between 2003 and 2021. Results. The use of edaravone in patients with subarachnoid hemorrhage was accompanied by the activation of anti-inflammatory and reduction of pro-inflammatory peptides, activation of anti-apoptotic mechanisms, reduction of lipid peroxidation, oxidative trauma, the permeability of the brain swelling. Conclusions. The main effects of edaravon (xavron) have been found to reduce neurological deficits, accelerate the recovery of neurological disorders, and improve functional outcomes. Thus, the introduction of edaravone in patients with subarachnoid hemorrhage has been proven to be reliably effective and safe.

scholarly journals Application of a free radical scavenger edaravone in patients with hemorrhagic stroke

2021 ◽  
pp. 28-36
Author(s):  
O.A. Halushko
Keyword(s):  
Free Radical ◽  
Intracerebral Hemorrhage ◽  
Hemorrhagic Stroke ◽  
Hemorrhagic Transformation ◽  
Free Radical Scavenger ◽  
Neurological Deficits ◽  
Radical Scavenger ◽  
Rate Of Recovery ◽  
Main Effects

BACKGROUND. The free radical scavenger edaravone helps to reduce the area of ischemic injury and improve the longterm effects of stroke, and is therefore widely used in the treatment of ischemic stroke. However, the role of edaravone in the treatment of hemorrhagic stroke patients has not yet been clarified. OBJECTIVE. To investigate the feasibility and effectiveness of the use of the free radical scavenger edaravone in the treatment of patients with acute hemorrhagic stroke. MATERIALS AND METHODS. A search was conducted for studies and systematic reviews for the keywords “acute stroke”, “intracerebral hemorrhage”, “subarachnoid hemorrhage”, “hemorrhagic transformation”, “edaravone” in the Google Scholar database published between 2003 and 2020. RESULTS. The use of edaravone in patients with intracerebral hemorrhage was accompanied by activation of anti-inflammatory and reduction of pro-inflammatory peptides, activation of anti-apoptotic mechanisms, reduction of lipid peroxidation and oxidative trauma, reduction of permeability of the hematocenosis. CONCLUSIONS. The main effects of edaravone have been to reduce neurological deficits, accelerate the rate of recovery of neurological disorders, and improve functional outcomes. Thus, the introduction of edaravone in patients with hemorrhagic stroke has proven to be reliably effective and safe.

scholarly journals Possible Protective Role of Melatonin in Pediatric Infectious Diseases and Neurodevelopmental Pathologies

2020 ◽  
Vol 10 (01) ◽  
pp. e104-e109
Author(s):  
Antonio Molina-Carballo ◽  
Antonio Emilio Jerez-Calero ◽  
Antonio Muñoz-Hoyos
Keyword(s):  
Endothelial Cell ◽  
Free Radical ◽  
Chronic Administration ◽  
Protective Role ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Energetic Metabolism ◽  
Beneficial Effects ◽  
Molecular Crosstalk

AbstractMelatonin, produced in every cell that possesses mitochondria, acts as an endogenous free radical scavenger, and improves energetic metabolism and immune function, by complex molecular crosstalk with other intracellular compounds. There is greatly increasing evidence regarding beneficial effects of acute and chronic administration of high melatonin doses, in infectious, developmental, and degenerative pathologies, as an endothelial cell and every cell protectant.

scholarly journals Dissociation and Protection of the Neurovascular Unit after Thrombolysis and Reperfusion in Ischemic Rat Brain

2009 ◽  
Vol 29 (4) ◽  
pp. 715-725 ◽  
Author(s):  
Toru Yamashita ◽  
Tatsushi Kamiya ◽  
Kentaro Deguchi ◽  
Toshiki Inaba ◽  
Hanzhe Zhang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Free Radical ◽  
Basement Membrane ◽  
Spontaneously Hypertensive Rat ◽  
Neurovascular Unit ◽  
Hemorrhagic Transformation ◽  
Artery Occlusion ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Electron Microscopic

In the ischemic brain, reperfusion with tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT); however, the mechanism remains elusive. Here, we show that the basement membrane, and not the endothelial cells, is vulnerable to ischemic/reperfusion injury with tPA treatment. We treated a spontaneously hypertensive rat model of middle cerebral artery occlusion (MCAO) with vehicle alone, tPA alone, or a free radical scavenger, edaravone, plus tPA. Light and electron microscopic analyses of each microvascular component revealed that the basement membrane disintegrated and became detached from the astrocyte endfeet in tPA-treated animals that showed HT. On the other hand, edaravone prevented the dissociation of the neurovascular unit, dramatically decreased the HT, and improved the neurologic score and survival rate of the tPA-treated rats. These results suggest that the basement membrane that underlies the endothelial cells is a key structure for maintaining the integrity of the neurovascular unit, and a free-radical scavenger can be a viable agent for inhibiting tPA-induced HT.

Role of Free Radical Scavenger in Protection of Spinal Cord during Ischemia

1986 ◽  
Vol 41 (5) ◽  
pp. 551-556 ◽  
Author(s):  
John C. Coles ◽  
S. Naeem Ahmed ◽  
Harendra U. Mehta ◽  
John C.E. Kaufmann
Keyword(s):  
Spinal Cord ◽  
Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger

Effects of tempol, a free radical scavenger, on long-term hyperdynamic porcine bacteremia*

2005 ◽  
Vol 33 (5) ◽  
pp. 1057-1063 ◽  
Author(s):  
Martin Matejovic ◽  
Ales Krouzecky ◽  
Vendula Martinkova ◽  
Richard Rokyta ◽  
Jaroslav Radej ◽  
...  
Keyword(s):  
Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger
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