scholarly journals Changes of lipid metabolism in patients with rheumatoid arthritis and concomitant arterial hypertension, abdominal obesity and diabetes mellitus type 2 depending on the gene polymorphism T-786C of endothelial nitric oxide synthase

2017 ◽  
Vol 13 (1) ◽  
pp. 79-84 ◽  
Author(s):  
O.P. Bukach ◽  
O.I. Fediv ◽  
L.P. Sydorchuk
Keyword(s):  
Rheumatoid Arthritis ◽  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Endothelial Nitric Oxide Synthase ◽  
Diabetes Mellitus Type 2 ◽  
Obesity And Diabetes ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Metformin and vildagliptin combination: A new approach of endothelial nitric oxide synthase activity regulation and metabolism in diabetes mellitus type 2

2018 ◽  
Vol 16 (2) ◽  
pp. 5-12
Author(s):  
Aleksandr L Urakov ◽  
Konstantin G Gurevich ◽  
Iuliia A Sorokina ◽  
Liubov V Lovtsova ◽  
Olga V Zanozina ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Endothelial Nitric Oxide Synthase ◽  
Diabetes Mellitus Type 2 ◽  
Activity Regulation ◽  
New Approach ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Nitric Oxide Synthase Activity

This review analyzes the research results of additional effects and mechanisms of action of sugar-reducing drugs. Hence it has been suggested that asymmetric dimethylarginine may be a target molecule for metformin, vildagliptin, and combinations thereof. (For citation: Urakov AL, Gurevich KG, Sorokina IA, et al. Metformin and vildagliptin combination: a new approach of endothelial nitric oxide synthase activity regulation and metabolism in diabetes mellitus type 2. Reviews on Clinical Pharmacology and Drug Therapy. 2018;16(2):5-12. doi: 10.17816/RCF1625-12).

scholarly journals Endothelial Nitric Oxide Synthase Gene Polymorphism (G894T) and Diabetes Mellitus (Type II) among South Indians

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
T. Angeline ◽  
H. R. Krithiga ◽  
W. Isabel ◽  
A. J. Asirvatham ◽  
A. Poornima
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Enzyme Analysis ◽  
Genotype Distribution ◽  
South Indians ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

The objective of the study is to find out whether the endothelial nitric oxide synthase (eNOS) G894T single-nucleotide polymorphism is associated with type 2 diabetes mellitus in South Indian (Tamil) population. A total number of 260 subjects comprising 100 type 2 diabetic mellitus patients and 160 healthy individuals with no documented history of diabetes were included for the study. DNA was isolated, and eNOS G894T genotyping was performed using the polymerase chain reaction followed by restriction enzyme analysis usingBan II. The genotype distribution in patients and controls were compatible with the Hardy-Weinberg expectations (P>0.05). Odds ratio indicates that the occurrence of mutant genotype (GT/TT) was 7.2 times (95% CI = 4.09–12.71) more frequent in the cases than in controls. Thus, the present study demonstrates that there is an association of endothelial nitric oxide synthase gene (G894T) polymorphism with diabetes mellitus among South Indians.

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