scholarly journals Development of humanized mouse models to study human malaria parasite infection

2012 ◽  
Vol 7 (5) ◽  
pp. 657-665 ◽  
Author(s):  
Ashley M Vaughan ◽  
Stefan HI Kappe ◽  
Alexander Ploss ◽  
Sebastian A Mikolajczak
Keyword(s):  
Mouse Models ◽  
Malaria Parasite ◽  
Parasite Infection ◽  
Humanized Mouse ◽  
Human Malaria Parasite ◽  
Human Malaria ◽  
Malaria Parasite Infection ◽  
Humanized Mouse Models

scholarly journals Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections

2014 ◽  
Vol 16 (5) ◽  
pp. 602-611 ◽  
Author(s):  
Alexis Kaushansky ◽  
Sebastian A. Mikolajczak ◽  
Marissa Vignali ◽  
Stefan H. I. Kappe
Keyword(s):  
Mouse Models ◽  
Malaria Parasite ◽  
Humanized Mouse ◽  
Human Malaria Parasite ◽  
Human Malaria ◽  
Parasite Infections ◽  
Humanized Mouse Models

scholarly journals Aquatic Exposure to Abscisic Acid Transstadially Enhances Anopheles stephensi Resistance to Malaria Parasite Infection

Genes ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1393
Author(s):  
Dean M. Taylor ◽  
Reagan S. Haney ◽  
Shirley Luckhart
Keyword(s):  
Abscisic Acid ◽  
Malaria Parasite ◽  
Anopheles Stephensi ◽  
Impact Resistance ◽  
Parasite Infection ◽  
Larval Rearing ◽  
Human Malaria Parasite ◽  
Malaria Parasite Infection ◽  
Immature Development ◽  
Mammalian Blood

The ancient stress signaling molecule abscisic acid (ABA) is ubiquitous in animals and plants but is perhaps most well-known from its early discovery as a plant hormone. ABA can be released into water by plants and is found in nectar, but is also present in mammalian blood, three key contexts for mosquito biology. We previously established that addition of ABA to Anopheles stephensi larval rearing water altered immature development and life history traits of females derived from treated larvae, while addition of ABA to an infected bloodmeal increased resistance of adult female A. stephensi to human malaria parasite infection. Here we sought to determine whether larval treatment with ABA could similarly impact resistance to parasite infection in females derived from treated larvae and, if so, whether resistance could be extended to another parasite species. We examined nutrient levels and gene expression to demonstrate that ABA can transstadially alter resistance to a rodent malaria parasite with hallmarks of previously observed mechanisms of resistance following provision of ABA in blood to A. stephensi.

scholarly journals Perspectives on Non-BLT Humanized Mouse Models for Studying HIV Pathogenesis and Therapy

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 776
Author(s):  
Kazutaka Terahara ◽  
Ryutaro Iwabuchi ◽  
Yasuko Tsunetsugu-Yokota
Keyword(s):  
Mouse Models ◽  
Humanized Mice ◽  
Lymphoid Tissues ◽  
Humanized Mouse ◽  
Hiv Pathogenesis ◽  
Hematopoietic Stem ◽  
Critical Issues ◽  
In Vivo Animal Models ◽  
Humanized Mouse Models

A variety of humanized mice, which are reconstituted only with human hematopoietic stem cells (HSC) or with fetal thymus and HSCs, have been developed and widely utilized as in vivo animal models of HIV-1 infection. The models represent some aspects of HIV-mediated pathogenesis in humans and are useful for the evaluation of therapeutic regimens. However, there are several limitations in these models, including their incomplete immune responses and poor distribution of human cells to the secondary lymphoid tissues. These limitations are common in many humanized mouse models and are critical issues that need to be addressed. As distinct defects exist in each model, we need to be cautious about the experimental design and interpretation of the outcomes obtained using humanized mice. Considering this point, we mainly characterize the current conventional humanized mouse reconstituted only with HSCs and describe past achievements in this area, as well as the potential contributions of the humanized mouse models for the study of HIV pathogenesis and therapy. We also discuss the use of various technologies to solve the current problems. Humanized mice will contribute not only to the pre-clinical evaluation of anti-HIV regimens, but also to a deeper understanding of basic aspects of HIV biology.

scholarly journals Plasmodium knowlesi: An Important Yet Overlooked Human Malaria Parasite

2009 ◽  
Vol 84 (7) ◽  
pp. 664
Author(s):  
Balaji Yegneswaran ◽  
David Alcid ◽  
Janani Mohan
Keyword(s):  
Malaria Parasite ◽  
Plasmodium Knowlesi ◽  
Human Malaria Parasite ◽  
Human Malaria
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