scholarly journals Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry

2020 ◽  
Vol 21 (18) ◽  
pp. 1311-1329
Author(s):  
Georgia Ragia ◽  
Vangelis G Manolopoulos
Keyword(s):  
At Risk ◽  
Genetic Factors ◽  
Genetic Data ◽  
Disease Course ◽  
Risk Population ◽  
Epigenetic Diversity

There is considerable variation in disease course among individuals infected with SARS-CoV-2. Many of them do not exhibit any symptoms, while some others proceed to develop COVID-19; however, severity of COVID-19 symptoms greatly differs among individuals. Focusing on the early events related to SARS-CoV-2 entry to cells through the ACE2 pathway, we describe how variability in (epi)genetic factors can conceivably explain variability in disease course. We specifically focus on variations in ACE2, TMPRSS2 and FURIN genes, as central components for SARS-CoV-2 infection, and on other molecules that modulate their expression such as CALM, ADAM-17, AR and ESRs. We propose a genetic classifier for predicting SARS-CoV-2 infectivity potential as a preliminary tool for identifying the at-risk-population. This tool can serve as a dynamic scaffold being updated and adapted to validated (epi)genetic data. Overall, the proposed approach holds potential for better personalization of COVID-19 handling.

Towards Polio Eradication in Nigeria: Identifying at Risk Population for Low Oral Polio Vaccine (OPV) Uptake

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 389A-389A
Author(s):  
Oluyemisi O. Falope ◽  
Korede K. Adegoke ◽  
Chukwudi O. Ejiofor ◽  
Nnadozie C. Emechebe ◽  
Taiwo O Talabi ◽  
...  
Keyword(s):  
At Risk ◽  
Oral Polio Vaccine ◽  
Polio Eradication ◽  
Risk Population ◽  
Polio Vaccine

scholarly journals Influenza vaccination during the coronavirus pandemic: intention to vaccinate among the at-risk population in the Central Catalonia Health Region (VAGCOVID)

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Anna Bonet-Esteve ◽  
Raquel Muñoz-Miralles ◽  
Carla Gonzalez-Claramunt ◽  
Ana M Rufas ◽  
Xavier Pelegrin Cruz ◽  
...  
Keyword(s):  
At Risk ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Vaccination Coverage ◽  
Perceived Risk ◽  
Seasonal Influenza ◽  
Public Health Issue ◽  
Risk Population ◽  
Previous Season ◽  
The Individual

Abstract Background Influenza is a major public health issue, with the primary preventive measure being an annual influenza vaccination. Nevertheless, vaccination coverage among the at-risk population is low. Our understanding of the behaviour of the influenza virus during the SARS-CoV-2 coronavirus pandemic is limited, meaning influenza vaccination is still recommended for individuals at risk for severe complications due to influenza infection. The aim of the study is to determine the intention to vaccinate against seasonal influenza among the at-risk population in the 2020-21 campaign during the SARS-CoV-2 pandemic and to analyse the factors which influence such intention. Methods Cross-sectional telephone survey of adults (aged over 18) with risk factors in central Catalonia where the need for the Seasonal Influenza Vaccine (SIV) was recommended. Results A total of 434 participants responded to the survey, 43.3% of whom intended to be vaccinated against influenza for the 2020-2021 influenza season, 40.8% had no intention to be vaccinated and 15.9% were uncertain or did not express their opinion. The intention to get vaccinated against influenza is associated with having dependents, the individual’s perception of the risk of being infected with influenza and the perceived risk of transmission to dependents. It is also associated with age, whether the individual had received influenza vaccine the previous season or any other season before. The best predictors of the intention to vaccinate are the individual’s perception of the risk of catching influenza and whether the individual had been vaccinated in the previous season. Conclusions Intention to vaccinate can be a good predictor of individual behaviour in relation to vaccination. During the current SARS-CoV-2 pandemic many individuals are hesitant to influenza vaccination. In order to improve influenza vaccination coverage in people included in risk groups, it is necessary to promote educational actions, especially among those who express doubts.

Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis

2004 ◽  
Vol 10 (3) ◽  
pp. 266-271 ◽  
Author(s):  
B Zakrzewska-Pniewska ◽  
M Styczynska ◽  
A Podlecka ◽  
R Samocka ◽  
B Peplonska ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Apolipoprotein E ◽  
Brain Atrophy ◽  
Genetic Factors ◽  
Clinical Course ◽  
Progression Rate ◽  
Disease Course ◽  
Familial Cases ◽  
Sporadic Cases ◽  
The Relationship

The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized. In a large group of Polish patients we have tested the hypothesis that polymorphism in ApoE and MPO genes may influence the course of the disease. G enotypes were determined in 117 MS patients (74 females and 43 males; 99 sporadic and 18 familial cases) with mean EDSS of 3.6, mean age of 44.1 years, mean duration of the disease 12.8 years and mean onset of MS at 31.2 years, and in 100 healthy controls. The relationship between ApoE and MPO genes’ polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed. The ApoE o4 allele was not related to the disease course or the ApoE o2 to the intensity of demyelination on MRI. The genotype MPO G/G was found in all familial MS and in 57% (56/99) of sporadic cases. This genotype was also related to more pronounced brain atrophy on MRI. The MPO G/G subpopulation was characterized by a significantly higher proportion of patients with secondary progressive MS (PB- 0.05) and by a higher value of EDSS. A ccording to our results the MPO G allele is frequently found (in 96% of cases) among Polish patients with MS. More severe nervous tissue damage in the MPO G/G form can be explained by the mechanism of accelerated oxidative stress. It seems that MPO G/G genotype may be one of the genetic factors influencing the progression rate of disability in MS patients.

Determinants of exclusive breastfeeding cessation: identifying an “at risk population” for special support

2014 ◽  
Vol 174 (4) ◽  
pp. 533-540 ◽  
Author(s):  
Juliana F. Lindau ◽  
Simona Mastroeni ◽  
Andrea Gaddini ◽  
Domenico Di Lallo ◽  
Paolo Fiori Nastro ◽  
...  
Keyword(s):  
At Risk ◽  
Exclusive Breastfeeding ◽  
Risk Population ◽  
Special Support ◽  
Breastfeeding Cessation

Identifying An At-Risk Population of Children With Recurrent Near-Fatal Asthma Exacerbations

2010 ◽  
Vol 47 (4) ◽  
pp. 460-464 ◽  
Author(s):  
Christopher L. Carroll ◽  
Burcin Uygungil ◽  
Aaron R. Zucker ◽  
Craig M. Schramm
Keyword(s):  
At Risk ◽  
Risk Population ◽  
Asthma Exacerbations ◽  
Fatal Asthma ◽  
Near Fatal Asthma

Defining an at-risk population for obstetric anal sphincter laceration

2009 ◽  
Vol 201 (5) ◽  
pp. 526.e1-526.e6 ◽  
Author(s):  
Steven M. Minaglia ◽  
Chieko Kimata ◽  
Karen A. Soules ◽  
Tamara Pappas ◽  
Ian A. Oyama
Keyword(s):  
At Risk ◽  
Anal Sphincter ◽  
Risk Population ◽  
Anal Sphincter Laceration ◽  
Sphincter Laceration

Development and initial testing of the BABY-BISCUIT in an at-risk population

2021 ◽  
pp. 1-9
Author(s):  
Johnny L. Matson ◽  
Megan M. Callahan ◽  
Joshua J. Montrenes
Keyword(s):  
At Risk ◽  
Risk Population ◽  
Initial Testing

Priorities for African youth for engaging in DOHaD

2017 ◽  
Vol 9 (1) ◽  
pp. 15-19 ◽  
Author(s):  
A. J. Macnab ◽  
R. Mukisa
Keyword(s):  
At Risk ◽  
Health Promotion ◽  
Health Behaviors ◽  
Good Health ◽  
Economic Factors ◽  
Risk Population ◽  
What Works ◽  
Health Promoting School ◽  
Health Promoting ◽  
African Youth

A challenge for implementing DOHaD-defined health promotion is how to engage the at-risk population. The WHO Health Promoting School (HPS) model has proven success engaging youth and improving health behaviors. Hence, we introduced DOHaD concepts to 151 pupils aged 12–15 years in three HPS programs in rural Uganda, inquired what factors would make DOHaD-related health promotion resonate with them, and discussed how they recommended making learning about DOHaD acceptable to youth. Economic factors were judged the most compelling; with nutrition and responsive care elements next in importance. Suggested approaches included: teach how good health is beneficial, what works and why, and give tools to use to achieve it, and make information positive rather than linked to later harm. Involve youth in making DOHaD learning happen, make being a parent sound interesting, and include issues meaningful to boys. These are the first data from youth charged with addressing their engagement in the DOHaD agenda.

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