Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients

2010 ◽  
Vol 11 (9) ◽  
pp. 1223-1234 ◽  
Author(s):  
Laure Elens ◽  
Bernard Vandercam ◽  
Jean-Cyr Yombi ◽  
Dominique Lison ◽  
Pierre Wallemacq ◽  
...  
AIDS ◽  
2011 ◽  
Vol 25 (18) ◽  
pp. 2217-2226 ◽  
Author(s):  
Daniëlle van Manen ◽  
Luuk Gras ◽  
Brigitte D. Boeser-Nunnink ◽  
Ard I. van Sighem ◽  
Irma Maurer ◽  
...  

2012 ◽  
Vol 32 (3) ◽  
pp. 143-151 ◽  
Author(s):  
Animesh Chatterjee ◽  
Anurag Rathore ◽  
Sanjukta Vidyant ◽  
Kavita Kakkar ◽  
Tapan N. Dhole

A multitude of host genetic factors plays a crucial role in susceptibility to HIV-1 infection and progression to AIDS, which is highly variable among individuals and populations. This review focuses on the chemokine-receptor and chemokine genes, which were extensively studied because of their role as HIV co-receptor or co-receptor competitor and influences the susceptibility to HIV-1 infection and progression to AIDS in HIV-1 infected individuals.


2021 ◽  
pp. ASN.2021040543
Author(s):  
Nicholas J. Steers ◽  
Yask Gupta ◽  
Vivette D. D’Agati ◽  
Tze Y. Lim ◽  
Natalia DeMaria ◽  
...  

BackgroundTo gain insight into the pathogenesis of collapsing glomerulopathy, a rare form of FSGS that often arises in the setting of viral infections, we performed a genome-wide association study (GWAS) among inbred mouse strains using a murine model of HIV-1 associated nephropathy (HIVAN).MethodsWe first generated F1 hybrids between HIV-1 transgenic mice on the FVB/NJ background and 20 inbred laboratory strains. Analysis of histology, BUN, and urinary NGAL demonstrated marked phenotypic variation among the transgenic F1 hybrids, providing strong evidence for host genetic factors in the predisposition to nephropathy. A GWAS in 365 transgenic F1 hybrids generated from these 20 inbred strains was performed.ResultsWe identified a genome-wide significant locus on chromosome 13-C3 and multiple additional suggestive loci. Crossannotation of the Chr. 13 locus, including single-cell transcriptomic analysis of wildtype and HIV-1 transgenic mouse kidneys, nominated Ssbp2 as the most likely candidate gene. Ssbp2 is highly expressed in podocytes, encodes a transcriptional cofactor that interacts with LDB1 and LMX1B, which are both previously implicated in FSGS. Consistent with these data, older Ssbp2 null mice spontaneously develop glomerulosclerosis, tubular casts, interstitial fibrosis, and inflammation, similar to the HIVAN mouse model.ConclusionsThese findings demonstrate the utility of GWAS in mice to uncover host genetic factors for rare kidney traits and suggest Ssbp2 as susceptibility gene for HIVAN, potentially acting via the LDB1-LMX1B transcriptional network.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Michelle L. Wright ◽  
Jennifer M. Fettweis ◽  
Lindon J. Eaves ◽  
Judy L. Silberg ◽  
Michael C. Neale ◽  
...  

AbstractThe diversity and dominant bacterial taxa in the vagina are reported to be influenced by multiple intrinsic and extrinsic factors, including but not limited to pregnancy, contraceptive use, pathogenic states, socioeconomic status, and ancestry. However, the extent to which host genetic factors influence variation in the vaginal microbiota is unclear. We used a biometrical genetic approach to determine whether host genetic factors contribute to inter-individual differences in taxa from a sample of 332 twins who self-identified as being of African (44 pairs) or European ancestry (122 pairs). Lactobacillus crispatus, a major determinant of vaginal health, was identified as heritable among European American women (narrow-sense heritability = 34.7%, P-value = 0.018). Heritability of L. crispatus is consistent with the reduced prevalence of adverse reproductive disorders, including bacterial vaginosis and preterm birth, among women of European ancestry.


2004 ◽  
Vol 10 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Jeymohan Joseph ◽  
Toby Behar

2012 ◽  
Vol 171 (24) ◽  
pp. 624.2-624 ◽  
Author(s):  
R. A. Scholey ◽  
R. W. Blowey ◽  
R. D. Murray ◽  
R. F. Smith ◽  
J. Cameron ◽  
...  

2021 ◽  
Vol 1 ◽  
pp. 1-None
Author(s):  
Alexis Bénard ◽  
Hélène Henri ◽  
Camille Noûs ◽  
Fabrice Vavre ◽  
Natacha Kremer

Sign in / Sign up

Export Citation Format

Share Document