Is Anti-Müllerian Hormone Associated with IVF Outcomes in Young Patients with Diminished Ovarian Reserve?

Reduced ovarian reserve is a condition characterized by a reduced competence of the ovary to produce oocyte due to advanced age or congenital, medical, surgical and idiopathic causes. Age is considered to be the principal factor in determining the reduction of ovarian reserve, especially in woman over 40 years of age, but it's well known that a premature reduction of ovarian reserve can also occur in young patients. Management of patients with diminished ovarian reserve is challenging for fertility experts and frequently the only option to conceive is represented by assisted reproduction technologies. Here we review the aetiology, presentation and diagnosis of reduced ovarian reserve both in advanced and in young age and we discuss recent advances in the management of infertility of these women.Faridpur Med. Coll. J. Jul 2016;11(2): 74-80

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Young diminished ovarian reserve (DOR) patients have good IVF outcomes

Fertility and Sterility ◽

10.1016/j.fertnstert.2014.07.1087 ◽

2014 ◽

Vol 102 (3) ◽

pp. e321

Author(s):

S.R. Pittenger ◽

C.-N. Kao ◽

M.P. Rosen ◽

M.I. Cedars ◽

N.D. Tran

Keyword(s):

Ovarian Reserve ◽

Diminished Ovarian Reserve ◽

Ivf Outcomes

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Biological Ovarian Age Predestinate Female Fecundity? Exosomes in Follicular Microenvironment Expose the Potentiality of Young

10.21203/rs.3.rs-204965/v1 ◽

2021 ◽

Author(s):

Ting Hu ◽

Yun xing Fu ◽

Rong Hu ◽

Fei-Miao Wang ◽

Li-Guo Pei ◽

...

Keyword(s):

Electron Microscope ◽

Follicular Fluid ◽

Ovarian Reserve ◽

Underlying Mechanism ◽

Diminished Ovarian Reserve ◽

Control Group ◽

Biological Functions ◽

Female Fecundity ◽

Female Patients ◽

Ivf Outcomes

Abstract Background: This study aimed to investigate the biological functions of exosome in follicle microenvironment and illustrate the underlying mechanism about the different IVF outcomes among normal, diminished ovarian reserve (DOR) and aging female patients with the same biological ovarian age. Methods: Follicular fluid (FF) was collected from control(n=35), DOR(n=35), aging(n=35) who underwent IVF therapy in 2017 and 2018. Electron microscope and NanoSight were used to detect the exosomes morphology and concentration. Hormones levels and anti-Müllerian hormone (AMH) in the serum were detected by ELISA. Results: Serum FSH and FSH level of the DOR group and the aging group significantly increased, AFC was decreased compared to the control. Exosomes concentrations were significantly lower in DOR and aging as compared with control group and were also significantly lower in the aging group compared with the DOR group. Exosomes was negatively correlated with FSH and FSH/LH, exosomes was positively correlated with AMH. GDF9 and BMP15 were secreted by exosomes. Conclusions: Exosome was highly represented in human FF and are involved in maturation of follicle. The concentration of exosomes in FF can be an indicator of ovarian reserve. Oocytes may secrete exosomes.

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Assessment of Ovarian Reserve in Infertile Patients

Anwer Khan Modern Medical College Journal ◽

10.3329/akmmcj.v8i2.33671 ◽

2017 ◽

Vol 8 (2) ◽

pp. 132-143

Author(s):

Poly Begum ◽

Dipti Rani Shaha ◽

Mahbuba ◽

Lipika Sanjowal ◽

Ripon Barua ◽

...

Keyword(s):

Assisted Reproduction ◽

Ovarian Reserve ◽

Young Patients ◽

Principal Factor ◽

Diminished Ovarian Reserve ◽

Advanced Age ◽

Medical College ◽

Assisted Reproduction Technologies ◽

Over 40 Years ◽

Infertile Patients

Reduced ovarian reserve is a condition characterized by a reduced competence of the ovary to produce oocyte due to advanced age or congenital, medical surgical and idiopathic causes. Age is considered to be the principal factor in determining the reduction of ovarian reserve, especially in woman over 40 years of age, but it's well known that a premature reduction of ovarian reserve can also occur in young patients. Management of patients with diminished ovarian reserve is challenging for fertility experts and frequently the only option to conceive is represented by assisted reproduction technologies. Here we reviewed the aetiology, presentation and diagnosis of reduced ovarian reserve in advanced and young aged women and recent advances in the management of infertility in these women.Anwer Khan Modern Medical College Journal Vol. 8, No. 2: Jul 2017, P 132-143

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