scholarly journals Assessment of Ovarian Reserve in Infertile Patients

2017 ◽  
Vol 11 (2) ◽  
pp. 74-80
Author(s):  
Poly Begum ◽  
Dipti Rani Shaha ◽  
Lipika Sanjowal ◽  
Ripon Barua ◽  
Md Kamrul Hassan
Keyword(s):  
Assisted Reproduction ◽  
Ovarian Reserve ◽  
Young Patients ◽  
Principal Factor ◽  
Young Age ◽  
Diminished Ovarian Reserve ◽  
Advanced Age ◽  
Assisted Reproduction Technologies ◽  
Over 40 Years ◽  
Infertile Patients

Reduced ovarian reserve is a condition characterized by a reduced competence of the ovary to produce oocyte due to advanced age or congenital, medical, surgical and idiopathic causes. Age is considered to be the principal factor in determining the reduction of ovarian reserve, especially in woman over 40 years of age, but it's well known that a premature reduction of ovarian reserve can also occur in young patients. Management of patients with diminished ovarian reserve is challenging for fertility experts and frequently the only option to conceive is represented by assisted reproduction technologies. Here we review the aetiology, presentation and diagnosis of reduced ovarian reserve both in advanced and in young age and we discuss recent advances in the management of infertility of these women.Faridpur Med. Coll. J. Jul 2016;11(2): 74-80

scholarly journals Assessment of Ovarian Reserve in Infertile Patients

2017 ◽  
Vol 8 (2) ◽  
pp. 132-143
Author(s):  
Poly Begum ◽  
Dipti Rani Shaha ◽  
Mahbuba ◽  
Lipika Sanjowal ◽  
Ripon Barua ◽  
...  
Keyword(s):  
Assisted Reproduction ◽  
Ovarian Reserve ◽  
Young Patients ◽  
Principal Factor ◽  
Diminished Ovarian Reserve ◽  
Advanced Age ◽  
Medical College ◽  
Assisted Reproduction Technologies ◽  
Over 40 Years ◽  
Infertile Patients

Reduced ovarian reserve is a condition characterized by a reduced competence of the ovary to produce oocyte due to advanced age or congenital, medical surgical and idiopathic causes. Age is considered to be the principal factor in determining the reduction of ovarian reserve, especially in woman over 40 years of age, but it's well known that a premature reduction of ovarian reserve can also occur in young patients. Management of patients with diminished ovarian reserve is challenging for fertility experts and frequently the only option to conceive is represented by assisted reproduction technologies. Here we reviewed the aetiology, presentation and diagnosis of reduced ovarian reserve in advanced and young aged women and recent advances in the management of infertility in these women.Anwer Khan Modern Medical College Journal Vol. 8, No. 2: Jul 2017, P 132-143

scholarly journals Young patients with diminished ovarian reserve undergoing assisted reproductive treatments: a preliminary report

2005 ◽  
Vol 11 (3) ◽  
pp. 294-299 ◽  
Author(s):  
Banu Kumbak ◽  
Engin Oral ◽  
Semra Kahraman ◽  
Guvenc Karlikaya ◽  
Hale Karagozoglu
Keyword(s):  
Ovarian Reserve ◽  
Preliminary Report ◽  
Young Patients ◽  
Diminished Ovarian Reserve

Value of serum and follicular fluid Sirt1,Sirt2 protein levels in predicting the outcome of assisted reproduction

2020 ◽  
Author(s):  
Lingnv Yao ◽  
Wenqin Lin ◽  
Nan Jiang ◽  
Chuyan Li ◽  
Haifeng Cao ◽  
...  
Keyword(s):  
Assisted Reproduction ◽  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Advanced Age ◽  
Control Group ◽  
Age Group ◽  
Protein Levels ◽  
Study Population

Abstract Background: To explore whether serum and follicular fluid Sirt1, Sirt2 can reflect ovarian reserve and predict the outcome of assisted reproduction. Methods: The study population comprised 125 patients , 39 in OPOI（occult form of premature ovarian insufficiency）group, 49 in advanced age group , and 37 in control group. The levels of serum Sirt1, Sirt2 were measured on the 2nd to 5th day of menstruation (bSirt1,bSirt2) and HCG day. Follicular fluid Sirt1 (FFSirt1) and Sirt2 (FFSirt2), were determined on OPU (oocyte pick up) day. Results: The level of FFSirt2 in the advanced age group was significantly lower than those in other two groups. FFSirt 2 and Sirt 2 (HCG day ) were negatively correlated with age (r=-0.35, r=-0.19), but there were no value of them for assessing DOR (diminished ovarian reserve). The level of bSirt2 in (cumulative) pregnant group was significantly higher (r=0.24, P=0.00). Conclusions: This was the first study to show that FFSirt2 and Sirt2 (HCG day) might be negatively correlated with age and antral follicle count (AFC). bSirt2 could predict cumulative pregnancy outcome together with anti-Mullerian hormone (AMH), AFC and age.

scholarly journals Comparative study of assisted reproductive outcomes between young patients with occult premature ovarian insufficiency and advanced-age patients

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052093465
Author(s):  
Ling-nv Yao ◽  
Wen-qin Lin ◽  
Nan Jiang ◽  
Chuyan Li ◽  
Hai-feng Cao ◽  
...  
Keyword(s):  
Live Birth ◽  
Ovarian Reserve ◽  
Embryo Implantation ◽  
Young Patients ◽  
Abortion Rate ◽  
Advanced Age ◽  
Premature Ovarian Insufficiency ◽  
Ovarian Insufficiency ◽  
Vitro Fertilization

Objective The purpose of this study was to compare the pregnancy outcomes among young patients with occult premature ovarian insufficiency (OPOI), advanced-age patients with diminished ovarian reserve (DOR), and advanced-age patients with normal ovarian reserve. Methods We retrospectively reviewed 324 women who underwent their first cycles of in vitro fertilization/intracytoplasmic sperm injection. The women were divided into the following groups: young women with OPOI, advanced-age women with DOR, and advanced-age women with normal ovarian reserve. The outcomes were compared among the different groups: Results The rates of live birth and embryo implantation in the young OPOI group were significantly higher than in the advanced-age DOR group, but comparable to those in the advanced-age normal ovarian reserve group. Moreover, the abortion rate was significantly lower in young OPOI patients compared with advanced-age patients with or without DOR. Conclusion Higher embryo implantation and live birth rates and a lower abortion rate can be achieved in young patients with OPOI compared with older patients. The better outcomes in advanced-age patients with normal ovarian reserve compared with DOR may be related to egg quantity rather than quality.

scholarly journals Is Anti-Müllerian Hormone Associated with IVF Outcomes in Young Patients with Diminished Ovarian Reserve?

2016 ◽  
Vol 12 (2) ◽  
pp. 185-192 ◽  
Author(s):  
Nigel Pereira ◽  
Robert Setton ◽  
Allison C Petrini ◽  
Jovana P Lekovich ◽  
Rony T Elias ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Young Patients ◽  
Diminished Ovarian Reserve ◽  
Ivf Outcomes

MicroRNAs with Altered Expression Profiles in Granulosa of Women of Advanced Age with Diminished Ovarian Reserve

2020 ◽  
Vol 10 (10) ◽  
pp. 2316-2323
Author(s):  
Danqi Liu ◽  
Fang Lian ◽  
Shan Xiang ◽  
Ying Guo ◽  
Haicui Wu ◽  
...  
Keyword(s):  
Young Women ◽  
Ovarian Reserve ◽  
Target Genes ◽  
Expression Profiles ◽  
Micro Rna ◽  
Diminished Ovarian Reserve ◽  
Advanced Age ◽  
Altered Expression ◽  
Age Related ◽  
Microrna Sequencing

Objective: The objective of this study was to investigate the micro-RNA differences between women of advanced age with a diminished ovarian reserve (DOR) and young women with a normal ovarian reserve (NOR), and the causes leading to the decline of ovarian reserve function and oocyte function in women, which may be related to aging. Methods: The prospective cohort investigation method was used in this study. We used microRNA sequencing to detect the microRNA expression profiles for women of advanced age with DOR function and young women with NOR function. Then, the differentially expressed microRNAs were compared and the agerelated mechanism was predicted by the target genes. Results: The microRNA sequencing results revealed that 70 microRNA expressions were different, including 45 downregulated expressions and 25 upregulated expressions. Specifically, miR-221-3p, miR-146b-5p, miR-378a-3p, miR-143-5p, miR-222-5p, and miR-221-5p were significantly downregulated; miR-6881-3p, miR-4787-3p, miR-4745-5p, miR-6513-3p, and miR-3179 were upregulated. The primary pathways are PI3K-Akt, MAPK, Phospholipase D, and Chemokine. Conclusions: Differences were observed between the expression profiles of microRNAs in the granulosa cells of the ovaries of patients with DOR and NOR. These differences may be age-related.

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