scholarly journals A Case Report of Alcoholic Liver Disease with Jaundice Treated with Korean Medicine

2021 ◽  
Vol 42 (5) ◽  
pp. 949-957
Author(s):  
Jae-yoon Ahn ◽  
Sang-song Sim ◽  
Sol Jeong ◽  
Yong-jeen Shin ◽  
Kang-san Kim ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Mean Corpuscular Volume ◽  
Total Bilirubin ◽  
Corpuscular Volume ◽  
Gamma Glutamyl Transpeptidase ◽  
Korean Medicine ◽  
Blood Tests ◽  
Glutamyl Transpeptidase

Objective: This study aimed to report a case of alcoholic liver disease with jaundice that was improved with Korean medicine treatment.Methods: A patient who developed jaundice due to continuous drinking was treated with herbal medicine, acupuncture, moxibustion, and cupping. Blood tests were performed to measure the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (γ-GTP), total bilirubin, albumin, and total protein; AST/ALT ratio; and mean corpuscular volume (MCV). Jaundice parameters were subjectively recorded at 3-day intervals.Results: After treatment, the AST, ALT, ALP, γ-GTP, and total bilirubin levels; MCV; and jaundice were decreased.Conclusion: Korean medicine treatment appeared to be an effective method for alcoholic liver disease with jaundice.

Serum Gamma-Glutamyl Transpeptidase Activity as an Indicator of Disease of Liver, Pancreas, or Bone

1972 ◽  
Vol 18 (4) ◽  
pp. 358-362 ◽  
Author(s):  
Gifford Lum ◽  
S Raymond Gambino
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Disease ◽  
Viral Hepatitis ◽  
Bone Disease ◽  
Leucine Aminopeptidase ◽  
Serum Alkaline Phosphatase ◽  
Metastatic Carcinoma ◽  
Gamma Glutamyl Transpeptidase ◽  
Serum Alkaline Phosphatase Activity ◽  
Glutamyl Transpeptidase

Abstract Serum γ-glutamyl transpeptidase (GGT), leucine aminopeptidase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were assayed in controls and in patients with liver, pancreatic, or bone disease. GGT activity was above normal in all forms of liver disease studied (viral hepatitis, cirrhosis, cholecystitis, metastatic carcinoma to liver, pancreatic carcinoma, liver granuloma, and acute pancreatitis). GGT more sensitively indicated hepatic disease than did alkaline phosphatase, much more so than did leucine aminopeptidase. GGT was disproportionately more active in relation to the transaminases in cases of intraor extrahepatic biliary obstruction; the reverse was true in cases of viral hepatitis. GGT activity was normal in children, adolescents, and pregnant women, and in cases of bone disease and renal failure. Kinetic measurement of GGT activity offers a simple, sensitive, and direct means for distinguishing whether bone or liver is the source of increased serum alkaline phosphatase activity. Activity was highest in obstructive liver disease.

scholarly journals Amiodarone-Induced Cirrhosis of Liver: What Predicts Mortality?

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Nasir Hussain ◽  
Anirban Bhattacharyya ◽  
Suartcha Prueksaritanond
Keyword(s):  
Alkaline Phosphatase ◽  
Side Effects ◽  
Prospective Studies ◽  
Statistical Difference ◽  
Total Bilirubin ◽  
Latency Period ◽  
Refractory Angina ◽  
Gamma Glutamyl Transpeptidase ◽  
Cirrhosis Of Liver ◽  
Glutamyl Transpeptidase

Introduction. Amiodarone has been used for more than 5 decades for the treatment of various tachyarrhythmias and previously for the treatment of refractory angina. There are multiple well-established side effects of amiodarone. However, amiodarone-induced cirrhosis (AIC) of liver is an underrecognized complication. Methods. A systematic search of Medline from January 1970 to November 2012 by using the following terms, amiodarone and cirrhosis, identified 37 reported cases of which 30 were used in this analysis. Patients were divided into 2 subsets, survivors versus nonsurvivors, at 5 months. Results. Aspartate aminotransferase was significantly lower (P=0.03) in patients who survived at 5-months (mean 103.33 IU/L) compared to nonsurvivors (mean 216.88 IU/L). There was no statistical difference in the levels of prothrombin time, total bilirubin, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, cumulative dose, and latency period between the two groups. The prevalence of DM, HTN, HLD, CAD, and CHF was similar in the two groups. None of the above-mentioned variables could be identified as a predictor of survival at 5 months. Conclusion. AIC carries a mortality risk of 60% at 5 months once the diagnosis is established. Further prospective studies are needed to identify predictors of AIC and of mortality or survival in cases of AIC.

Gamma Glutamyl Transpeptidase and Mean Corpuscular Volume: Their Usefulness in the Assessment of In-Patient Alcoholics

1986 ◽  
Vol 149 (3) ◽  
pp. 353-356 ◽  
Author(s):  
Richard W. Latcham
Keyword(s):  
Mean Corpuscular Volume ◽  
Problem Drinking ◽  
Corpuscular Volume ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Psychiatric Beds ◽  
Glutamyl Transpeptidase

Gamma glutamyl transpeptidase and mean corpuscular volume are shown to be of little value in the assessment of patients admitted to psychiatric beds for problem drinking.

Effect of Drinking on Correlations between Biochemical Variables

1981 ◽  
Vol 18 (3) ◽  
pp. 143-145 ◽  
Author(s):  
J B Whitfield ◽  
J K Allen ◽  
M A Adena ◽  
W J Hensley
Keyword(s):  
Uric Acid ◽  
Alcohol Consumption ◽  
Mean Corpuscular Volume ◽  
Laboratory Tests ◽  
Clinical Laboratory ◽  
Corpuscular Volume ◽  
Test Results ◽  
Gamma Glutamyl Transpeptidase ◽  
Highly Correlated ◽  
Glutamyl Transpeptidase

Several clinical laboratory tests correlate with alcohol consumption, for example, the plasma activities of gamma-glutamyl transpeptidase (GGT) and aspartate aminotransferase (AST), the concentrations of triglycerides (TG) and uric acid (UA) and the erythrocyte mean corpuscular volume (MCV). The correlations of these test results with each other have been studied in a population of men attending a multiphasic health-screening centre. The patterns of correlation were of two types: those between the pairs of variables GGT/TG, GGT/UA, TG/AST, and TG/UA were all unchanged as the level of alcohol consumption increased; the pairs of variables GGT/MCV, UA/AST, AST/MCV, UA/MCV, and GGT/AST all became more highly correlated as the level of alcohol consumption increased.

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