scholarly journals Can intermittent fasting help in stem-cell rejuvenation?

2021 ◽  
Vol 11 (6-S) ◽  
pp. 156-160
Author(s):  
S Seshadhri ◽  
Sundaram Rajagopal Shanmuga ◽  
Ramanathan Sambathkumar

Background: Human tissues are sustained by stem cells, the balance between stem cell self-renewal and differentiation, and cell death is the crucial element of haemostasis, which plays a vital role in tissue remodelling. Stem cell therapy is recognized as regenerative medicine. We can stimulate stem cell growth/regeneration through various events. Objectives: In this review, we illustrate whether fasting can stimulate stem cell regeneration. Methodology: A literature survey was undertaken to gather recent research and address the effects of fasting on stem cell renewal, which was the review's purpose. Results:  Enterocytes in drosophila were restored after exposure to the dietary restriction. As the result, fasting before etoposide exposure safeguarded mice against harm caused by etoposide when compared with the fed group. A study conducted on the effects of periodic fasting in yeast, mice, and humans shows the increase in lifespan and stress resistance of yeast fasting reduces the risks due to age factors and diseases like diabetes, cardiovascular diseases and promotes a healthy life span of mice and human. Conclusion: Dietary limitations will be used in conjunction with the existing therapeutic approach as adjuvant therapy. It will be a more effective treatment. Fasting has the potential to protect against the negative effects of chemotherapy while also boosting stem cell regeneration, according to preclinical findings. Even though regenerative medicine and stem cell therapy are still in their embryonic stage, greater interventions are needed to show the target pathway of fasting in stem cell renewal. Keywords: Fasting, stem cell regeneration, emerging therapy.

2009 ◽  
Vol 84 (10) ◽  
pp. 859-861 ◽  
Author(s):  
Timothy O'Brien ◽  
Frank P. Barry

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Michelle R. Santoso ◽  
Phillip C. Yang

Stem cell therapy has broad applications in regenerative medicine and increasingly within cardiovascular disease. Stem cells have emerged as a leading therapeutic option for many diseases and have broad applications in regenerative medicine. Injuries to the heart are often permanent due to the limited proliferation and self-healing capability of cardiomyocytes; as such, stem cell therapy has become increasingly important in the treatment of cardiovascular diseases. Despite extensive efforts to optimize cardiac stem cell therapy, challenges remain in the delivery and monitoring of cells injected into the myocardium. Other fields have successively used nanoscience and nanotechnology for a multitude of biomedical applications, including drug delivery, targeted imaging, hyperthermia, and tissue repair. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been widely employed for molecular and cellular imaging. In this mini-review, we focus on the application of superparamagnetic iron oxide nanoparticles in targeting and monitoring of stem cells for the treatment of myocardial infarctions.


2012 ◽  
Vol 73 (12) ◽  
pp. 1287-1294 ◽  
Author(s):  
Dominique Charron ◽  
Caroline Suberbielle-Boissel ◽  
Ryad Tamouza ◽  
Reem Al-Daccak

Author(s):  
Nagendra Kumar Chandrawanshi ◽  
Shekhar Verma

Cancer is the most prevalent and dangerous disease, and it leads to millions of deaths worldwide. Generally, metastatic cancer cells are not eradication by conventional surgical operative or chemotherapy-based treatment. New pathways have been established in various arenas such as unique biology, modulators regulatory mechanism, directional migration, self-renewal, etc. The individual pathways can be employed as therapeutic carriers, specific drug targeting, generation of acquiring nature immune cells, and regenerative medicine. The present scenario, stem cell therapy, focused on a promising tool for targeted cancer treatment. Stem cells also utilized as viruses and nanoparticles carry to enhance the primary therapeutic application in various dimensions such as cancer target therapy, regenerative medicine, immune-modulating therapy, and anticancer drugs screening. Furthermore, the rapid development in next-generation sequencing techniques and cancer genomics and proteomics analysis approaches are making therapeutics targeting organ-specific cancer more precise and efficient.


2020 ◽  
Vol 11 ◽  
Author(s):  
Babak Arjmand ◽  
Masoumeh Sarvari ◽  
Sepideh Alavi-Moghadam ◽  
Moloud Payab ◽  
Parisa Goodarzi ◽  
...  

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